PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
solute carrier family 16 member 7ENSG00000118596SLC16A7chr12:59596067-59789855:+Tbio45.8257
C-X-C motif chemokine ligand 6ENSG00000124875CXCL6chr4:73836497-73849064:+Tbio53.6091
mitogen-activated protein kinase kinase kinase kinase 1ENSG00000104814MAP4K1chr19:38587641-38618882:-Tchem38.254
insulin like growth factor binding protein 6ENSG00000167779IGFBP6chr12:53097436-53102345:+Tchem105.482
ATP binding cassette subfamily A member 6ENSG00000154262ABCA6chr17:69078702-69141888:-Tbio5.13333
lymphotoxin beta receptorENSG00000111321LTBRchr12:6375045-6391571:+Tbio147.55
DNA primase subunit 1ENSG00000198056PRIM1chr12:56731596-56752373:-Tbio51.1223
potassium inwardly rectifying channel subfamily J member 15ENSG00000157551KCNJ15chr21:38157034-38307357:+Tbio19.1968
defensin alpha 6ENSG00000164822DEFA6chr8:6924693-6926076:-Tbio6.66667
signal peptide, CUB domain and EGF like domain containing 2ENSG00000175356SCUBE2chr11:9020391-9138114:-Tbio12.6409
prepronociceptinENSG00000168081PNOCchr8:28316986-28343355:+Tbio376.325
calumeninENSG00000128595CALUchr7:128739292-128771807:+Tbio40.4309
R-spondin 3ENSG00000146374RSPO3chr6:127118604-127197765:+Tbio16.141
myotubularin related protein 2ENSG00000087053MTMR2chr11:95832882-95925315:-Tbio44.1309
ATP binding cassette subfamily G member 5ENSG00000138075ABCG5chr2:43812472-43838865:-Tbio110.204
tubulin beta 4A class IVaENSG00000104833TUBB4Achr19:6494319-6502848:-Tclin69.6796
C-X-C motif chemokine ligand 16ENSG00000161921CXCL16chr17:4733526-4739922:-Tbio170.248
arginine vasopressin receptor 2ENSG00000126895AVPR2chrX:153902531-153907166:+Tclin427.329
ATPase Na+/K+ transporting subunit alpha 2ENSG00000018625ATP1A2chr1:160115759-160143591:+Tclin141.686
inosine monophosphate dehydrogenase 2ENSG00000178035IMPDH2chr3:49024325-49029408:-Tclin83.4944

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