PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| solute carrier family 16 member 7 | ENSG00000118596 | SLC16A7 | chr12:59596067-59789855:+ | Tbio | 45.8257 |
| C-X-C motif chemokine ligand 6 | ENSG00000124875 | CXCL6 | chr4:73836497-73849064:+ | Tbio | 53.6091 |
| mitogen-activated protein kinase kinase kinase kinase 1 | ENSG00000104814 | MAP4K1 | chr19:38587641-38618882:- | Tchem | 38.254 |
| insulin like growth factor binding protein 6 | ENSG00000167779 | IGFBP6 | chr12:53097436-53102345:+ | Tchem | 105.482 |
| ATP binding cassette subfamily A member 6 | ENSG00000154262 | ABCA6 | chr17:69078702-69141888:- | Tbio | 5.13333 |
| lymphotoxin beta receptor | ENSG00000111321 | LTBR | chr12:6375045-6391571:+ | Tbio | 147.55 |
| DNA primase subunit 1 | ENSG00000198056 | PRIM1 | chr12:56731596-56752373:- | Tbio | 51.1223 |
| potassium inwardly rectifying channel subfamily J member 15 | ENSG00000157551 | KCNJ15 | chr21:38157034-38307357:+ | Tbio | 19.1968 |
| defensin alpha 6 | ENSG00000164822 | DEFA6 | chr8:6924693-6926076:- | Tbio | 6.66667 |
| signal peptide, CUB domain and EGF like domain containing 2 | ENSG00000175356 | SCUBE2 | chr11:9020391-9138114:- | Tbio | 12.6409 |
| prepronociceptin | ENSG00000168081 | PNOC | chr8:28316986-28343355:+ | Tbio | 376.325 |
| calumenin | ENSG00000128595 | CALU | chr7:128739292-128771807:+ | Tbio | 40.4309 |
| R-spondin 3 | ENSG00000146374 | RSPO3 | chr6:127118604-127197765:+ | Tbio | 16.141 |
| myotubularin related protein 2 | ENSG00000087053 | MTMR2 | chr11:95832882-95925315:- | Tbio | 44.1309 |
| ATP binding cassette subfamily G member 5 | ENSG00000138075 | ABCG5 | chr2:43812472-43838865:- | Tbio | 110.204 |
| tubulin beta 4A class IVa | ENSG00000104833 | TUBB4A | chr19:6494319-6502848:- | Tclin | 69.6796 |
| C-X-C motif chemokine ligand 16 | ENSG00000161921 | CXCL16 | chr17:4733526-4739922:- | Tbio | 170.248 |
| arginine vasopressin receptor 2 | ENSG00000126895 | AVPR2 | chrX:153902531-153907166:+ | Tclin | 427.329 |
| ATPase Na+/K+ transporting subunit alpha 2 | ENSG00000018625 | ATP1A2 | chr1:160115759-160143591:+ | Tclin | 141.686 |
| inosine monophosphate dehydrogenase 2 | ENSG00000178035 | IMPDH2 | chr3:49024325-49029408:- | Tclin | 83.4944 |
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