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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
platelet activating factor receptor	ENSG00000169403	PTAFR	chr1:28147166-28193936:-	Tchem	254.006
protein tyrosine phosphatase receptor type G	ENSG00000144724	PTPRG	chr3:61561569-62297613:+	Tchem	43.5316
ephrin A1	ENSG00000169242	EFNA1	chr1:155127460-155134857:+	Tbio	122.488
tubulin beta 2B class IIb	ENSG00000137285	TUBB2B	chr6:3224261-3231730:-	Tclin	15.1478
prosaposin	ENSG00000197746	PSAP	chr10:71816298-71851375:-	Tbio	197.7
transient receptor potential cation channel subfamily V member 4	ENSG00000111199	TRPV4	chr12:109783085-109833401:-	Tchem	339.808
ADAM metallopeptidase with thrombospondin type 1 motif 15	ENSG00000166106	ADAMTS15	chr11:130448974-130476641:+	Tbio	5.96612
large tumor suppressor kinase 1	ENSG00000131023	LATS1	chr6:149658153-149718256:-	Tbio	67.4761
TNF receptor superfamily member 1B	ENSG00000028137	TNFRSF1B	chr1:12167003-12209228:+	Tbio	761.164
lysophosphatidic acid receptor 3	ENSG00000171517	LPAR3	chr1:84811602-84893213:-	Tchem	104.098
afamin	ENSG00000079557	AFM	chr4:73481683-73504001:+	Tbio	424.611
serpin family A member 3	ENSG00000273259	SERPINA3	chr14:94592058-94624646:+	Tbio	867.601
mitogen-activated protein kinase 15	ENSG00000181085	MAPK15	chr8:143716259-143722458:+	Tchem	18.3649
solute carrier family 35 member D3	ENSG00000182747	SLC35D3	chr6:136922264-136925639:+	Tdark	2.14236
solute carrier family 22 member 12	ENSG00000197891	SLC22A12	chr11:64590641-64602353:+	Tclin	187.691
bromodomain and PHD finger containing 1	ENSG00000156983	BRPF1	chr3:9731729-9748018:+	Tchem	17.7706
solute carrier family 18 member A1	ENSG00000036565	SLC18A1	chr8:20144855-20183206:-	Tchem	54.0401
neurturin	ENSG00000171119	NRTN	chr19:5823802-5828324:+	Tbio	87.4151
folate receptor gamma	ENSG00000110203	FOLR3	chr11:72114869-72139892:+	Tbio	9.13406
EPH receptor A1	ENSG00000146904	EPHA1	chr7:143390289-143408892:-	Tchem	76.7577

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