Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 218 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| TNNC1 | ENSG00000114854 | 0.00 | 0.34 | 0 | 2 |
| PAOX | ENSG00000148832 | 0.00 | 0.75 | 0 | 5 |
| MEP1A | ENSG00000112818 | 0.00 | 0.00 | 0 | 0 |
| LAMP3 | ENSG00000078081 | 0.19 | 0.00 | 1 | 0 |
| DDR2 | ENSG00000162733 | 0.00 | 0.00 | 0 | 0 |
| CLCN7 | ENSG00000103249 | 0.00 | 0.32 | 0 | 2 |
| GCK | ENSG00000106633 | 0.00 | 0.00 | 0 | 0 |
| SLC22A17 | ENSG00000092096 | 0.28 | 0.00 | 1 | 0 |
| WHSC1L1 | ENSG00000147548 | 2.65 | 0.00 | 7 | 0 |
| CD55 | ENSG00000196352 | 0.00 | 0.00 | 0 | 0 |
| CD200R1 | ENSG00000163606 | 0.00 | 0.00 | 0 | 0 |
| CYP3A4 | ENSG00000160868 | 0.00 | 0.00 | 0 | 0 |
| CAPN5 | ENSG00000149260 | 0.15 | 0.00 | 1 | 0 |
| NRG2 | ENSG00000158458 | 0.00 | 0.14 | 0 | 1 |
| DYRK1A | ENSG00000157540 | 0.25 | 0.00 | 2 | 0 |
| LTBP2 | ENSG00000119681 | 0.00 | 0.10 | 0 | 1 |
| QPCT | ENSG00000115828 | 0.00 | 0.00 | 0 | 0 |
| SETD8 | ENSG00000183955 | 0.00 | 0.16 | 0 | 1 |
| SLC16A9 | ENSG00000165449 | 0.00 | 0.00 | 0 | 0 |
| PDE12 | ENSG00000174840 | 0.00 | 0.65 | 0 | 4 |
|
Showing page 218 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.