Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR4N4 | ENSG00000183706 | 0.00 | 0.00 | 0 | 0 |
| IFNL2 | ENSG00000183709 | 0.00 | 0.00 | 0 | 0 |
| NPBWR1 | ENSG00000183729 | 0.15 | 0.00 | 1 | 0 |
| CBX6 | ENSG00000183741 | 0.00 | 0.00 | 0 | 0 |
| AIFM3 | ENSG00000183773 | 0.29 | 0.00 | 1 | 0 |
| TUBA8 | ENSG00000183785 | 0.00 | 0.00 | 0 | 0 |
| CCR4 | ENSG00000183813 | 0.00 | 0.00 | 0 | 0 |
| CNGA2 | ENSG00000183862 | 0.00 | 0.00 | 0 | 0 |
| ARSI | ENSG00000183876 | 0.00 | 0.00 | 0 | 0 |
| UTY | ENSG00000183878 | 0.00 | 0.00 | 0 | 0 |
| LRRC55 | ENSG00000183908 | 0.00 | 0.00 | 0 | 0 |
| SDR42E2 | ENSG00000183921 | 0.00 | 0.00 | 0 | 0 |
| KCNH8 | ENSG00000183960 | 0.00 | 0.00 | 0 | 0 |
| NPW | ENSG00000183971 | 0.00 | 0.00 | 0 | 0 |
| NPB | ENSG00000183979 | 0.00 | 0.00 | 0 | 0 |
| PTP4A2 | ENSG00000184007 | 0.00 | 0.19 | 0 | 1 |
| OR2T10 | ENSG00000184022 | 0.00 | 0.00 | 0 | 0 |
| OR7E87P | ENSG00000184055 | 0.00 | 0.00 | 0 | 0 |
| OR4F6 | ENSG00000184140 | 0.00 | 0.00 | 0 | 0 |
| LRTOMT | ENSG00000184154 | 0.92 | 0.00 | 1 | 0 |
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