Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 91 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| TAC3 | ENSG00000166863 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.06 | 0.03 | 0.00 | 0.00 | 0.02 | 0.02 | 0.12 | 0.00 | 0.04 | 0.01 | 0.03 | 0.02 | 0.08 | 0.04 | 0.11 | 0.02 | 0.02 | 0.00 | 0.02 | 0.01 | 0.03 | 0.01 | 0.07 | 0.01 | 0.06 | 0.01 | 0.19 | 0.03 | 0.06 | 0.00 | 0.00 | 0.00 | 0.04 | 0.04 | 0.14 | 0.04 | 0.05 | 0.00 | 0.05 | 0.01 | 0.16 | 0.06 | 0.25 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.02 | 0.02 | 0.08 | 0.04 | 0.00 | 0.00 | 0.09 | 0.02 |
| OR4D6 | ENSG00000166884 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.02 | 0.01 | 0.10 | 0.02 | 0.00 | 0.00 | 0.07 | 0.03 | 0.03 | 0.03 | 0.07 | 0.02 | 0.11 | 0.03 | 0.07 | 0.04 | 0.01 | 0.04 | 0.01 | 0.01 | 0.03 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.04 | 0.07 | 0.06 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.10 | 0.07 | 0.12 | 0.05 | 0.05 | 0.02 | 0.05 | 0.02 | 0.14 | 0.17 | 0.05 | 0.06 | 0.00 | 0.07 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.06 | 0.04 |
| XRCC6BP1 | ENSG00000166896 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.11 | 0.03 | 0.00 | 0.00 | 0.02 | 0.02 | 0.32 | 0.00 | 0.07 | 0.01 | 0.05 | 0.02 | 0.09 | 0.03 | 0.14 | 0.02 | 0.01 | 0.00 | 0.05 | 0.02 | 0.04 | 0.01 | 0.07 | 0.01 | 0.31 | 0.01 | 0.39 | 0.02 | 0.06 | 0.00 | 0.00 | 0.00 | 0.10 | 0.03 | 0.16 | 0.05 | 0.04 | 0.00 | 0.02 | 0.01 | 0.12 | 0.05 | 1.42 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.22 | 0.02 | 0.82 | 0.03 | 0.00 | 0.00 | 0.24 | 0.02 |
| SCG5 | ENSG00000166922 | 0.00 | 0.00 | 0.01 | 0.02 | 0.14 | 0.00 | 0.02 | 0.05 | 0.03 | 0.09 | 0.00 | 0.00 | 0.01 | 0.29 | 0.03 | 0.10 | 0.05 | 0.10 | 0.03 | 0.04 | 0.08 | 0.06 | 0.03 | 0.07 | 0.02 | 0.07 | 0.01 | 0.05 | 0.01 | 0.04 | 0.01 | 0.02 | 0.00 | 0.07 | 0.04 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.12 | 0.09 | 0.32 | 0.03 | 0.05 | 0.03 | 0.08 | 0.07 | 0.48 | 0.07 | 0.08 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.02 | 0.01 | 0.11 | 0.00 | 0.00 | 0.03 | 0.14 |
| GREM1 | ENSG00000166923 | 0.00 | 0.00 | 0.00 | 0.02 | 0.14 | 0.00 | 0.02 | 0.05 | 0.03 | 0.09 | 0.00 | 0.00 | 0.01 | 0.30 | 0.01 | 0.10 | 0.05 | 0.10 | 0.03 | 0.04 | 0.08 | 0.06 | 0.02 | 0.07 | 0.02 | 0.07 | 0.01 | 0.05 | 0.00 | 0.04 | 0.01 | 0.02 | 0.00 | 0.07 | 0.04 | 0.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.12 | 0.08 | 0.32 | 0.03 | 0.05 | 0.02 | 0.08 | 0.07 | 0.48 | 0.07 | 0.08 | 0.02 | 0.03 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.02 | 0.01 | 0.11 | 0.00 | 0.00 | 0.04 | 0.14 |
| EPB42 | ENSG00000166947 | 0.00 | 0.01 | 0.00 | 0.02 | 0.14 | 0.00 | 0.01 | 0.06 | 0.02 | 0.06 | 0.00 | 0.00 | 0.02 | 0.33 | 0.00 | 0.10 | 0.01 | 0.09 | 0.02 | 0.04 | 0.05 | 0.05 | 0.01 | 0.08 | 0.01 | 0.09 | 0.00 | 0.06 | 0.00 | 0.04 | 0.01 | 0.02 | 0.00 | 0.07 | 0.02 | 0.09 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.10 | 0.05 | 0.35 | 0.01 | 0.09 | 0.02 | 0.08 | 0.18 | 0.30 | 0.06 | 0.07 | 0.01 | 0.03 | 0.00 | 0.00 | 0.02 | 0.15 | 0.00 | 0.03 | 0.01 | 0.11 | 0.00 | 0.00 | 0.01 | 0.17 |
| TGM6 | ENSG00000166948 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.00 | 0.02 | 0.03 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.04 | 0.05 | 0.14 | 0.01 | 0.03 | 0.03 | 0.07 | 0.03 | 0.04 | 0.02 | 0.05 | 0.04 | 0.06 | 0.09 | 0.00 | 0.03 | 0.04 | 0.01 | 0.00 | 0.03 | 0.00 | 0.09 | 0.00 | 0.02 | 0.01 | 0.00 | 0.04 | 0.06 | 0.30 | 0.08 | 0.03 | 0.03 | 0.07 | 0.03 | 0.17 | 0.07 | 0.07 | 0.07 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 |
| MARS | ENSG00000166986 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.06 | 0.03 | 0.00 | 0.00 | 0.02 | 0.02 | 0.19 | 0.01 | 0.03 | 0.01 | 0.04 | 0.02 | 0.11 | 0.04 | 0.12 | 0.01 | 0.02 | 0.01 | 0.02 | 0.01 | 0.04 | 0.02 | 0.06 | 0.01 | 0.06 | 0.01 | 0.40 | 0.03 | 0.06 | 0.00 | 0.00 | 0.00 | 0.06 | 0.04 | 0.15 | 0.06 | 0.03 | 0.00 | 0.03 | 0.01 | 0.10 | 0.06 | 0.41 | 0.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.22 | 0.02 | 0.61 | 0.04 | 0.00 | 0.00 | 0.16 | 0.03 |
| PDIA3 | ENSG00000167004 | 0.00 | 0.01 | 0.00 | 0.02 | 0.14 | 0.00 | 0.01 | 0.05 | 0.02 | 0.06 | 0.00 | 0.00 | 0.02 | 0.33 | 0.01 | 0.09 | 0.02 | 0.08 | 0.02 | 0.04 | 0.04 | 0.04 | 0.01 | 0.07 | 0.01 | 0.08 | 0.00 | 0.06 | 0.00 | 0.04 | 0.00 | 0.02 | 0.00 | 0.07 | 0.02 | 0.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.11 | 0.04 | 0.32 | 0.01 | 0.10 | 0.02 | 0.08 | 0.05 | 0.30 | 0.06 | 0.09 | 0.01 | 0.03 | 0.00 | 0.00 | 0.02 | 0.18 | 0.00 | 0.02 | 0.01 | 0.11 | 0.00 | 0.00 | 0.02 | 0.17 |
| DUSP18 | ENSG00000167065 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.04 | 0.23 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 0.04 | 0.03 | 0.18 | 0.01 | 0.02 | 0.00 | 0.03 | 0.01 | 0.02 | 0.02 | 0.03 | 0.01 | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.05 | 0.01 | 0.07 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.02 | 0.27 | 0.05 | 0.04 | 0.00 | 0.13 | 0.01 | 0.14 | 0.08 | 0.04 | 0.03 | 0.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.04 | 0.00 | 0.00 | 0.03 | 0.05 |
| BPIFB6 | ENSG00000167104 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | 0.01 | 0.23 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.07 | 0.01 | 0.21 | 0.00 | 0.20 | 0.00 | 0.06 | 0.00 | 0.05 | 0.01 | 0.11 | 0.00 | 0.17 | 0.00 | 0.03 | 0.01 | 0.02 | 0.00 | 0.00 | 0.01 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.22 | 0.02 | 0.22 | 0.00 | 0.07 | 0.01 | 0.29 | 0.00 | 0.08 | 0.02 | 0.03 | 0.00 | 0.00 | 0.02 | 0.04 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 |
| ENDOG | ENSG00000167136 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | 0.04 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.05 | 0.02 | 0.06 | 0.03 | 0.06 | 0.02 | 0.11 | 0.05 | 0.11 | 0.02 | 0.01 | 0.01 | 0.04 | 0.03 | 0.00 | 0.01 | 0.04 | 0.03 | 0.06 | 0.01 | 0.09 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 | 0.04 | 0.09 | 0.20 | 0.04 | 0.01 | 0.04 | 0.05 | 0.12 | 0.11 | 0.04 | 0.08 | 0.02 | 0.06 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.01 | 0.04 | 0.02 | 0.00 | 0.00 | 0.03 | 0.02 |
| ISLR2 | ENSG00000167178 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.02 | 0.00 | 0.03 | 0.04 | 0.02 | 0.00 | 0.00 | 0.09 | 0.00 | 0.05 | 0.02 | 0.05 | 0.02 | 0.02 | 0.03 | 0.09 | 0.03 | 0.05 | 0.03 | 0.02 | 0.01 | 0.03 | 0.03 | 0.03 | 0.01 | 0.04 | 0.03 | 0.00 | 0.01 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.08 | 0.03 | 0.16 | 0.13 | 0.12 | 0.01 | 0.04 | 0.04 | 0.26 | 0.03 | 0.05 | 0.11 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.00 | 0.13 | 0.01 |
| IGF2 | ENSG00000167244 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.01 | 0.02 | 0.01 | 0.11 | 0.00 | 0.00 | 0.02 | 0.05 | 0.03 | 0.07 | 0.01 | 0.16 | 0.02 | 0.07 | 0.02 | 0.15 | 0.07 | 0.06 | 0.20 | 0.01 | 0.20 | 0.03 | 0.01 | 0.06 | 0.04 | 0.03 | 0.03 | 0.01 | 0.09 | 0.05 | 0.04 | 0.06 | 0.00 | 0.00 | 0.03 | 0.12 | 0.05 | 0.47 | 0.01 | 0.07 | 0.04 | 0.08 | 0.21 | 0.09 | 0.04 | 0.16 | 0.02 | 0.04 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.01 | 0.06 | 0.00 | 0.00 | 0.01 | 0.04 |
| CD3D | ENSG00000167286 | 0.02 | 0.01 | 0.00 | 0.06 | 0.02 | 0.02 | 0.02 | 0.08 | 0.04 | 0.10 | 0.00 | 0.02 | 0.07 | 0.04 | 0.05 | 0.07 | 0.05 | 0.09 | 0.05 | 0.16 | 0.04 | 0.12 | 0.07 | 0.07 | 0.01 | 0.01 | 0.03 | 0.03 | 0.01 | 0.02 | 0.02 | 0.09 | 0.00 | 0.17 | 0.03 | 0.05 | 0.00 | 0.06 | 0.00 | 0.00 | 0.03 | 0.23 | 0.14 | 0.14 | 0.04 | 0.30 | 0.05 | 0.05 | 0.20 | 0.16 | 0.03 | 0.21 | 0.00 | 0.15 | 0.02 | 0.00 | 0.14 | 0.01 | 0.07 | 0.01 | 0.01 | 0.01 | 0.00 | 0.07 | 0.00 | 0.25 |
| OR51I1 | ENSG00000167359 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.09 | 0.01 | 0.06 | 0.01 | 0.14 | 0.02 | 0.07 | 0.02 | 0.10 | 0.02 | 0.05 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.05 | 0.03 | 0.02 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.08 | 0.00 | 0.00 | 0.02 | 0.10 | 0.02 | 0.43 | 0.01 | 0.05 | 0.02 | 0.07 | 0.03 | 0.09 | 0.05 | 0.16 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.01 | 0.05 | 0.00 | 0.00 | 0.01 | 0.03 |
| OR51Q1 | ENSG00000167360 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.02 | 0.01 | 0.09 | 0.00 | 0.00 | 0.02 | 0.09 | 0.01 | 0.06 | 0.01 | 0.14 | 0.02 | 0.07 | 0.02 | 0.10 | 0.02 | 0.05 | 0.01 | 0.01 | 0.01 | 0.02 | 0.00 | 0.05 | 0.03 | 0.02 | 0.03 | 0.01 | 0.01 | 0.07 | 0.03 | 0.08 | 0.00 | 0.00 | 0.02 | 0.10 | 0.02 | 0.43 | 0.01 | 0.05 | 0.03 | 0.07 | 0.03 | 0.09 | 0.05 | 0.16 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.01 | 0.10 | 0.01 | 0.05 | 0.00 | 0.00 | 0.01 | 0.03 |
| VKORC1 | ENSG00000167397 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.11 | 0.01 | 0.10 | 0.01 | 0.03 | 0.02 | 0.07 | 0.00 | 0.06 | 0.00 | 0.05 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.09 | 0.01 | 0.08 | 0.03 | 0.02 | 0.03 | 0.12 | 0.00 | 0.52 | 0.05 | 0.06 | 0.02 | 0.02 | 0.01 | 0.00 | 0.02 | 0.05 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 |
| GPX4 | ENSG00000167468 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.02 | 0.15 | 0.05 | 0.00 | 0.03 | 0.10 | 0.05 | 0.09 | 0.02 | 0.15 | 0.01 | 0.15 | 0.04 | 0.18 | 0.04 | 0.08 | 0.01 | 0.07 | 0.02 | 0.09 | 0.00 | 0.07 | 0.02 | 0.14 | 0.04 | 0.03 | 0.18 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.02 | 0.17 | 0.03 | 0.91 | 0.04 | 0.24 | 0.02 | 0.26 | 0.00 | 0.73 | 0.23 | 0.20 | 0.01 | 0.01 | 0.00 | 0.02 | 0.07 | 0.00 | 0.05 | 0.02 | 0.07 | 0.01 | 0.01 | 0.02 | 0.03 | 0.08 |
| MVD | ENSG00000167508 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.06 | 0.01 | 0.25 | 0.08 | 0.05 | 0.00 | 0.00 | 0.00 | 0.19 | 0.02 | 0.12 | 0.03 | 0.06 | 0.04 | 0.04 | 0.09 | 0.05 | 0.05 | 0.05 | 0.02 | 0.03 | 0.02 | 0.03 | 0.02 | 0.01 | 0.02 | 0.08 | 0.05 | 0.05 | 0.07 | 0.06 | 0.00 | 0.02 | 0.00 | 0.01 | 0.05 | 0.09 | 0.05 | 0.34 | 0.05 | 0.08 | 0.02 | 0.08 | 0.03 | 0.29 | 0.06 | 0.10 | 0.00 | 0.12 | 0.00 | 0.04 | 0.03 | 0.00 | 0.00 | 0.02 | 0.01 | 0.05 | 0.00 | 0.02 | 0.02 | 0.10 |
|
Showing page 91 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.