Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 42 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| CXCL6 | ENSG00000124875 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.18 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.07 | 0.02 | 0.23 | 0.01 | 0.10 | 0.01 | 0.20 | 0.02 | 0.07 | 0.02 | 0.02 | 0.01 | 0.05 | 0.01 | 0.01 | 0.00 | 0.02 | 0.08 | 0.00 | 0.03 | 0.07 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.16 | 0.02 | 0.31 | 0.11 | 0.07 | 0.03 | 0.03 | 0.01 | 0.05 | 0.05 | 0.07 | 0.06 | 0.09 | 0.01 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 |
| EREG | ENSG00000124882 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.13 | 0.02 | 0.00 | 0.00 | 0.00 | 0.06 | 0.07 | 0.02 | 0.23 | 0.02 | 0.10 | 0.01 | 0.21 | 0.02 | 0.07 | 0.02 | 0.02 | 0.01 | 0.05 | 0.01 | 0.01 | 0.00 | 0.02 | 0.08 | 0.00 | 0.03 | 0.11 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.14 | 0.02 | 0.30 | 0.11 | 0.05 | 0.02 | 0.03 | 0.01 | 0.05 | 0.05 | 0.08 | 0.07 | 0.08 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 |
| SCGB1D2 | ENSG00000124935 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.01 | 0.01 | 0.13 | 0.01 | 0.00 | 0.00 | 0.12 | 0.00 | 0.05 | 0.02 | 0.05 | 0.02 | 0.14 | 0.02 | 0.12 | 0.02 | 0.03 | 0.02 | 0.01 | 0.02 | 0.02 | 0.03 | 0.00 | 0.02 | 0.04 | 0.02 | 0.13 | 0.07 | 0.08 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.09 | 0.07 | 0.16 | 0.04 | 0.06 | 0.00 | 0.09 | 0.01 | 0.27 | 0.12 | 0.07 | 0.03 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.05 | 0.05 |
| SCGB2A1 | ENSG00000124939 | 0.01 | 0.00 | 0.00 | 0.01 | 0.09 | 0.00 | 0.01 | 0.01 | 0.12 | 0.01 | 0.00 | 0.00 | 0.12 | 0.00 | 0.05 | 0.02 | 0.05 | 0.02 | 0.14 | 0.02 | 0.13 | 0.02 | 0.03 | 0.02 | 0.01 | 0.02 | 0.02 | 0.03 | 0.00 | 0.02 | 0.04 | 0.02 | 0.13 | 0.07 | 0.12 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.10 | 0.07 | 0.16 | 0.04 | 0.06 | 0.00 | 0.08 | 0.01 | 0.27 | 0.12 | 0.07 | 0.03 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.05 |
| WNT1 | ENSG00000125084 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.07 | 0.01 | 0.04 | 0.02 | 0.01 | 0.05 | 0.07 | 0.07 | 0.04 | 0.04 | 0.02 | 0.00 | 0.02 | 0.01 | 0.00 | 0.05 | 0.03 | 0.01 | 0.09 | 0.01 | 0.16 | 0.01 | 0.00 | 0.03 | 0.00 | 0.00 | 0.04 | 0.05 | 0.08 | 0.06 | 0.02 | 0.01 | 0.03 | 0.01 | 0.09 | 0.13 | 0.07 | 0.09 | 0.02 | 0.00 | 0.00 | 0.01 | 0.10 | 0.06 | 0.01 | 0.04 | 0.03 | 0.05 | 0.00 | 0.00 | 0.06 | 0.04 |
| GPR18 | ENSG00000125245 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.06 | 0.17 | 0.03 | 0.00 | 0.01 | 0.01 | 0.06 | 0.11 | 0.04 | 0.08 | 0.04 | 0.09 | 0.03 | 0.09 | 0.04 | 0.14 | 0.03 | 0.08 | 0.01 | 0.14 | 0.01 | 0.02 | 0.02 | 0.27 | 0.02 | 0.06 | 0.01 | 0.03 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.13 | 0.05 | 0.24 | 0.09 | 0.18 | 0.02 | 0.05 | 0.02 | 0.38 | 0.05 | 0.21 | 0.12 | 0.01 | 0.01 | 0.00 | 0.00 | 0.04 | 0.07 | 0.03 | 0.02 | 0.04 | 0.04 | 0.05 | 0.00 | 0.07 | 0.06 |
| SLC10A2 | ENSG00000125255 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.04 | 0.18 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.11 | 0.04 | 0.08 | 0.03 | 0.11 | 0.01 | 0.08 | 0.04 | 0.12 | 0.03 | 0.09 | 0.01 | 0.12 | 0.01 | 0.01 | 0.01 | 0.25 | 0.01 | 0.10 | 0.01 | 0.03 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.13 | 0.04 | 0.22 | 0.09 | 0.20 | 0.03 | 0.06 | 0.02 | 0.33 | 0.05 | 0.22 | 0.11 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.10 | 0.03 | 0.02 | 0.06 | 0.04 | 0.05 | 0.00 | 0.06 | 0.05 |
| AMELX | ENSG00000125363 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.00 | 0.06 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.05 | 0.08 | 0.06 | 0.02 | 0.02 | 0.06 | 0.08 | 0.06 | 0.03 | 0.01 | 0.01 | 0.12 | 0.02 | 0.00 | 0.01 | 0.03 | 0.02 | 0.00 | 0.01 | 0.07 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.06 | 0.03 | 0.14 | 0.18 | 0.08 | 0.00 | 0.06 | 0.02 | 0.06 | 0.09 | 0.11 | 0.06 | 0.05 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.01 | 0.01 | 0.03 | 0.00 | 0.00 | 0.05 | 0.02 |
| PTGER2 | ENSG00000125384 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.01 | 0.00 | 0.02 | 0.12 | 0.01 | 0.07 | 0.04 | 0.07 | 0.01 | 0.13 | 0.01 | 0.06 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.02 | 0.01 | 0.03 | 0.04 | 0.05 | 0.06 | 0.04 | 0.05 | 0.01 | 0.01 | 0.00 | 0.00 | 0.10 | 0.02 | 0.10 | 0.13 | 0.01 | 0.02 | 0.02 | 0.01 | 0.00 | 0.03 | 0.04 | 0.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.01 | 0.03 | 0.00 | 0.04 | 0.00 | 0.00 | 0.02 | 0.02 |
| SLC25A35 | ENSG00000125434 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.14 | 0.03 | 0.04 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.05 | 0.01 | 0.02 | 0.02 | 0.03 | 0.03 | 0.04 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.02 | 0.00 | 0.16 | 0.02 | 0.03 | 0.01 | 0.05 | 0.00 | 0.03 | 0.00 | 0.00 | 0.01 | 0.06 | 0.06 | 0.07 | 0.00 | 0.04 | 0.04 | 0.05 | 0.06 | 0.11 | 0.25 | 0.25 | 0.00 | 0.02 | 0.02 | 0.01 | 0.00 | 0.10 | 0.01 | 0.00 | 0.00 | 0.05 | 0.00 | 0.00 | 0.00 | 0.04 |
| SLC25A19 | ENSG00000125454 | 0.02 | 0.00 | 0.05 | 0.00 | 0.02 | 0.00 | 0.03 | 0.03 | 0.21 | 0.00 | 0.00 | 0.01 | 0.09 | 0.02 | 0.16 | 0.01 | 0.24 | 0.01 | 0.09 | 0.03 | 0.28 | 0.06 | 0.12 | 0.03 | 0.03 | 0.01 | 0.04 | 0.02 | 0.05 | 0.10 | 0.26 | 0.00 | 0.08 | 0.01 | 0.13 | 0.02 | 0.02 | 0.01 | 0.00 | 0.00 | 0.37 | 0.03 | 0.37 | 0.03 | 0.24 | 0.02 | 0.19 | 0.01 | 0.51 | 0.00 | 0.25 | 0.03 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.09 | 0.00 | 0.08 | 0.01 | 0.14 | 0.01 | 0.24 | 0.02 |
| KIR2DL1 | ENSG00000125498 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.03 | 0.00 | 0.19 | 0.02 | 0.00 | 0.00 | 0.01 | 0.04 | 0.05 | 0.05 | 0.09 | 0.09 | 0.05 | 0.02 | 0.12 | 0.03 | 0.11 | 0.03 | 0.02 | 0.02 | 0.01 | 0.04 | 0.03 | 0.04 | 0.06 | 0.02 | 0.02 | 0.07 | 0.21 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.15 | 0.03 | 0.17 | 0.26 | 0.12 | 0.06 | 0.06 | 0.05 | 0.25 | 0.10 | 0.07 | 0.18 | 0.00 | 0.06 | 0.01 | 0.00 | 0.13 | 0.03 | 0.01 | 0.18 | 0.02 | 0.12 | 0.00 | 0.00 | 0.04 | 0.04 |
| SRMS | ENSG00000125508 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.07 | 0.04 | 0.00 | 0.00 | 0.03 | 0.00 | 0.32 | 0.01 | 0.08 | 0.04 | 0.03 | 0.01 | 0.17 | 0.01 | 0.16 | 0.00 | 0.09 | 0.00 | 0.13 | 0.01 | 0.02 | 0.00 | 0.11 | 0.00 | 0.00 | 0.01 | 0.05 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.36 | 0.02 | 0.52 | 0.04 | 0.04 | 0.02 | 0.15 | 0.01 | 0.44 | 0.00 | 0.20 | 0.11 | 0.03 | 0.03 | 0.03 | 0.00 | 0.04 | 0.00 | 0.02 | 0.02 | 0.02 | 0.02 | 0.00 | 0.00 | 0.15 | 0.00 |
| NPBWR2 | ENSG00000125522 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.08 | 0.04 | 0.00 | 0.00 | 0.03 | 0.00 | 0.32 | 0.01 | 0.08 | 0.04 | 0.03 | 0.01 | 0.17 | 0.01 | 0.16 | 0.00 | 0.09 | 0.00 | 0.13 | 0.01 | 0.02 | 0.00 | 0.11 | 0.00 | 0.00 | 0.01 | 0.05 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.36 | 0.02 | 0.52 | 0.04 | 0.04 | 0.02 | 0.15 | 0.01 | 0.44 | 0.00 | 0.20 | 0.11 | 0.03 | 0.03 | 0.03 | 0.00 | 0.04 | 0.00 | 0.02 | 0.02 | 0.02 | 0.02 | 0.00 | 0.00 | 0.15 | 0.00 |
| IL1B | ENSG00000125538 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.06 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.08 | 0.01 | 0.09 | 0.01 | 0.19 | 0.02 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.15 | 0.10 | 0.05 | 0.01 | 0.14 | 0.01 | 0.14 | 0.00 | 0.12 | 0.02 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 |
| PLGLB2 | ENSG00000125551 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.04 | 0.08 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.02 | 0.02 | 0.08 | 0.01 | 0.05 | 0.02 | 0.09 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.02 | 0.04 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.04 | 0.02 | 0.10 | 0.04 | 0.04 | 0.01 | 0.04 | 0.02 | 0.08 | 0.03 | 0.17 | 0.04 | 0.01 | 0.04 | 0.00 | 0.00 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 |
| IL37 | ENSG00000125571 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.04 | 0.06 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.01 | 0.08 | 0.01 | 0.09 | 0.01 | 0.20 | 0.02 | 0.08 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.02 | 0.03 | 0.00 | 0.01 | 0.05 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.17 | 0.11 | 0.05 | 0.01 | 0.17 | 0.01 | 0.18 | 0.00 | 0.12 | 0.02 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.08 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.01 |
| PSPN | ENSG00000125650 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.03 | 0.03 | 0.10 | 0.00 | 0.01 | 0.01 | 0.09 | 0.01 | 0.06 | 0.03 | 0.09 | 0.02 | 0.09 | 0.02 | 0.11 | 0.01 | 0.08 | 0.02 | 0.03 | 0.00 | 0.06 | 0.00 | 0.05 | 0.01 | 0.12 | 0.00 | 0.01 | 0.01 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.08 | 0.10 | 0.58 | 0.03 | 0.17 | 0.01 | 0.21 | 0.02 | 0.56 | 0.17 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.09 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.05 | 0.04 | 0.03 |
| CLPP | ENSG00000125656 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.03 | 0.03 | 0.10 | 0.00 | 0.01 | 0.01 | 0.09 | 0.01 | 0.06 | 0.03 | 0.09 | 0.02 | 0.09 | 0.02 | 0.11 | 0.01 | 0.08 | 0.02 | 0.03 | 0.00 | 0.06 | 0.00 | 0.05 | 0.01 | 0.12 | 0.00 | 0.01 | 0.01 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.05 | 0.08 | 0.10 | 0.58 | 0.03 | 0.17 | 0.01 | 0.21 | 0.02 | 0.56 | 0.17 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.09 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.05 | 0.04 | 0.03 |
| GNRH2 | ENSG00000125787 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.00 | 0.02 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.03 | 0.03 | 0.04 | 0.13 | 0.01 | 0.03 | 0.03 | 0.07 | 0.03 | 0.04 | 0.01 | 0.06 | 0.04 | 0.06 | 0.09 | 0.01 | 0.03 | 0.04 | 0.01 | 0.00 | 0.03 | 0.00 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.05 | 0.05 | 0.32 | 0.07 | 0.04 | 0.02 | 0.09 | 0.03 | 0.09 | 0.07 | 0.07 | 0.08 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 |
|
Showing page 42 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.