Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 181 |
first page | previous page | next page | last page |
| KIRC | KIRP | KICH | PRAD | BLCA | THYM | MESO | LUAD | LUSC | HNSC | ESCA | STAD | COAD | READ | PAAD | LIHC | CHOL | ACC | PCPG | THCA | BRCA | OV | CESC | UCEC | UCS | SARC | TGCT | LAML | DLBC | LGG | GBM | UVM | SKCM | |||||||||||||||||||||||||||||||||||
| HGNC Symbol | Ensembl Gene ID | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del | Amp | Del |
| EPAS1 | ENSG00000116016 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.05 | 0.10 | 0.00 | 0.00 | 0.00 | 0.01 | 0.05 | 0.06 | 0.01 | 0.23 | 0.02 | 0.03 | 0.01 | 0.04 | 0.03 | 0.03 | 0.02 | 0.00 | 0.02 | 0.02 | 0.02 | 0.01 | 0.02 | 0.06 | 0.01 | 0.00 | 0.05 | 0.00 | 0.02 | 0.03 | 0.01 | 0.00 | 0.00 | 0.06 | 0.01 | 0.29 | 0.05 | 0.06 | 0.00 | 0.06 | 0.02 | 0.12 | 0.02 | 0.05 | 0.05 | 0.13 | 0.01 | 0.00 | 0.00 | 0.10 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.00 | 0.04 | 0.01 |
| BRD9 | ENSG00000028310 | 0.01 | 0.00 | 0.03 | 0.01 | 0.03 | 0.03 | 0.03 | 0.01 | 0.27 | 0.01 | 0.00 | 0.01 | 0.06 | 0.00 | 0.42 | 0.01 | 0.39 | 0.01 | 0.16 | 0.01 | 0.37 | 0.03 | 0.18 | 0.01 | 0.04 | 0.02 | 0.06 | 0.02 | 0.03 | 0.01 | 0.25 | 0.01 | 0.00 | 0.05 | 0.81 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 | 0.13 | 0.02 | 0.48 | 0.04 | 0.22 | 0.02 | 0.16 | 0.01 | 0.26 | 0.03 | 0.32 | 0.13 | 0.03 | 0.03 | 0.00 | 0.00 | 0.17 | 0.00 | 0.01 | 0.06 | 0.05 | 0.03 | 0.03 | 0.02 | 0.31 | 0.07 |
| ADAM33 | ENSG00000149451 | 0.01 | 0.00 | 0.01 | 0.00 | 0.05 | 0.00 | 0.01 | 0.03 | 0.04 | 0.02 | 0.00 | 0.00 | 0.00 | 0.05 | 0.03 | 0.04 | 0.13 | 0.01 | 0.03 | 0.02 | 0.07 | 0.03 | 0.06 | 0.01 | 0.06 | 0.04 | 0.05 | 0.08 | 0.00 | 0.03 | 0.05 | 0.01 | 0.00 | 0.03 | 0.01 | 0.08 | 0.00 | 0.01 | 0.00 | 0.00 | 0.06 | 0.05 | 0.29 | 0.07 | 0.04 | 0.01 | 0.09 | 0.03 | 0.09 | 0.06 | 0.09 | 0.07 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.02 | 0.02 |
| RBKS | ENSG00000171174 | 0.00 | 0.00 | 0.06 | 0.01 | 0.00 | 0.00 | 0.02 | 0.01 | 0.08 | 0.01 | 0.00 | 0.00 | 0.03 | 0.07 | 0.06 | 0.01 | 0.10 | 0.02 | 0.03 | 0.01 | 0.04 | 0.05 | 0.03 | 0.04 | 0.00 | 0.00 | 0.02 | 0.03 | 0.01 | 0.04 | 0.08 | 0.01 | 0.00 | 0.10 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.03 | 0.28 | 0.06 | 0.08 | 0.01 | 0.13 | 0.01 | 0.25 | 0.01 | 0.07 | 0.08 | 0.16 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 | 0.05 | 0.00 | 0.03 | 0.03 |
| MASP1 | ENSG00000127241 | 0.05 | 0.00 | 0.03 | 0.02 | 0.00 | 0.01 | 0.03 | 0.04 | 0.19 | 0.01 | 0.00 | 0.00 | 0.00 | 0.07 | 0.14 | 0.06 | 1.51 | 0.00 | 0.61 | 0.00 | 0.70 | 0.02 | 0.23 | 0.01 | 0.04 | 0.01 | 0.06 | 0.02 | 0.03 | 0.00 | 0.11 | 0.02 | 0.12 | 0.03 | 0.10 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.19 | 0.02 | 1.01 | 0.05 | 0.62 | 0.00 | 0.33 | 0.01 | 0.75 | 0.09 | 0.12 | 0.09 | 0.24 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.02 | 0.03 | 0.11 | 0.06 | 0.00 | 0.03 | 0.03 | 0.04 |
| PPWD1 | ENSG00000113593 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.00 | 0.18 | 0.02 | 0.17 | 0.00 | 0.01 | 0.00 | 0.03 | 0.01 | 0.08 | 0.01 | 0.10 | 0.02 | 0.07 | 0.02 | 0.15 | 0.01 | 0.12 | 0.00 | 0.07 | 0.03 | 0.06 | 0.00 | 0.07 | 0.00 | 0.03 | 0.00 | 0.13 | 0.11 | 0.00 | 0.00 | 0.03 | 0.00 | 0.00 | 0.02 | 0.10 | 0.03 | 0.63 | 0.00 | 0.09 | 0.01 | 0.12 | 0.06 | 0.35 | 0.04 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.04 | 0.03 |
| PVRL4 | ENSG00000143217 | 0.03 | 0.00 | 0.01 | 0.01 | 0.00 | 0.03 | 0.02 | 0.04 | 1.02 | 0.00 | 0.02 | 0.00 | 0.10 | 0.01 | 0.27 | 0.00 | 0.29 | 0.00 | 0.06 | 0.00 | 0.34 | 0.00 | 0.14 | 0.00 | 0.03 | 0.00 | 0.14 | 0.00 | 0.06 | 0.00 | 0.30 | 0.00 | 0.30 | 0.01 | 0.16 | 0.00 | 0.04 | 0.00 | 0.00 | 0.00 | 0.34 | 0.00 | 0.38 | 0.02 | 0.18 | 0.00 | 0.15 | 0.00 | 0.41 | 0.00 | 0.46 | 0.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.01 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.17 | 0.01 |
| LOXL2 | ENSG00000134013 | 0.00 | 0.03 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.23 | 0.01 | 0.15 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | 0.07 | 0.00 | 0.11 | 0.00 | 0.07 | 0.01 | 0.06 | 0.03 | 0.05 | 0.00 | 0.12 | 0.01 | 0.18 | 0.00 | 0.05 | 0.01 | 0.12 | 0.00 | 0.05 | 0.02 | 0.00 | 0.03 | 0.02 | 0.00 | 0.00 | 0.01 | 0.17 | 0.01 | 0.45 | 0.00 | 0.05 | 0.01 | 0.11 | 0.00 | 0.32 | 0.02 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.11 | 0.00 | 0.01 | 0.01 | 0.02 | 0.00 | 0.01 | 0.01 | 0.04 |
| SPNS3 | ENSG00000182557 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.09 | 0.06 | 0.03 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.06 | 0.02 | 0.03 | 0.02 | 0.03 | 0.06 | 0.04 | 0.03 | 0.02 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.12 | 0.00 | 0.03 | 0.02 | 0.04 | 0.00 | 0.03 | 0.00 | 0.00 | 0.03 | 0.05 | 0.11 | 0.07 | 0.02 | 0.03 | 0.05 | 0.03 | 0.12 | 0.12 | 0.16 | 0.24 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.06 | 0.03 |
| CLSTN1 | ENSG00000171603 | 0.00 | 0.06 | 0.01 | 0.08 | 0.00 | 0.00 | 0.01 | 0.06 | 0.10 | 0.08 | 0.00 | 0.02 | 0.04 | 0.27 | 0.07 | 0.06 | 0.06 | 0.12 | 0.05 | 0.09 | 0.09 | 0.11 | 0.10 | 0.08 | 0.01 | 0.14 | 0.00 | 0.21 | 0.04 | 0.07 | 0.03 | 0.27 | 0.00 | 1.10 | 0.03 | 0.21 | 0.01 | 0.11 | 0.00 | 0.00 | 0.02 | 0.19 | 0.25 | 0.35 | 0.04 | 0.09 | 0.08 | 0.12 | 0.16 | 0.25 | 0.18 | 0.22 | 0.08 | 0.11 | 0.02 | 0.01 | 0.00 | 0.07 | 0.00 | 0.05 | 0.05 | 0.23 | 0.00 | 0.10 | 0.06 | 0.11 |
| BMPR1B | ENSG00000138696 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.03 | 0.04 | 0.05 | 0.00 | 0.00 | 0.00 | 0.05 | 0.01 | 0.03 | 0.04 | 0.05 | 0.02 | 0.03 | 0.02 | 0.09 | 0.02 | 0.07 | 0.01 | 0.02 | 0.00 | 0.02 | 0.00 | 0.01 | 0.01 | 0.10 | 0.00 | 0.03 | 0.04 | 0.02 | 0.04 | 0.02 | 0.00 | 0.00 | 0.04 | 0.05 | 0.07 | 0.27 | 0.02 | 0.04 | 0.04 | 0.04 | 0.15 | 0.11 | 0.03 | 0.08 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.02 | 0.01 | 0.03 | 0.01 | 0.01 | 0.00 | 0.00 | 0.02 | 0.05 |
| EPHX1 | ENSG00000143819 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 | 0.08 | 0.09 | 0.04 | 0.02 | 0.02 | 0.05 | 0.01 | 0.08 | 0.01 | 0.13 | 0.01 | 0.05 | 0.00 | 0.22 | 0.05 | 0.12 | 0.01 | 0.03 | 0.01 | 0.05 | 0.01 | 0.01 | 0.01 | 0.15 | 0.03 | 0.18 | 0.02 | 0.04 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.23 | 0.02 | 0.41 | 0.05 | 0.08 | 0.01 | 0.11 | 0.02 | 0.23 | 0.00 | 0.03 | 0.24 | 0.03 | 0.05 | 0.02 | 0.00 | 0.03 | 0.15 | 0.01 | 0.02 | 0.02 | 0.05 | 0.09 | 0.00 | 0.13 | 0.05 |
| ALK | ENSG00000171094 | 0.00 | 0.00 | 0.04 | 0.02 | 0.00 | 0.00 | 0.01 | 0.01 | 0.08 | 0.00 | 0.00 | 0.00 | 0.03 | 0.08 | 0.06 | 0.02 | 0.12 | 0.01 | 0.03 | 0.01 | 0.05 | 0.04 | 0.03 | 0.03 | 0.00 | 0.00 | 0.02 | 0.03 | 0.01 | 0.03 | 0.07 | 0.01 | 0.00 | 0.10 | 0.03 | 0.03 | 0.01 | 0.00 | 0.00 | 0.01 | 0.06 | 0.02 | 0.24 | 0.06 | 0.08 | 0.00 | 0.10 | 0.01 | 0.27 | 0.00 | 0.08 | 0.06 | 0.16 | 0.01 | 0.00 | 0.00 | 0.02 | 0.02 | 0.00 | 0.00 | 0.03 | 0.01 | 0.05 | 0.00 | 0.03 | 0.03 |
| LGR5 | ENSG00000139292 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.03 | 0.01 | 0.25 | 0.02 | 0.00 | 0.00 | 0.03 | 0.02 | 0.15 | 0.02 | 0.17 | 0.01 | 0.14 | 0.02 | 0.28 | 0.03 | 0.17 | 0.03 | 0.00 | 0.01 | 0.04 | 0.04 | 0.05 | 0.03 | 0.02 | 0.00 | 0.00 | 0.01 | 0.30 | 0.02 | 0.05 | 0.02 | 0.00 | 0.00 | 0.24 | 0.02 | 0.24 | 0.06 | 0.06 | 0.01 | 0.09 | 0.01 | 0.36 | 0.09 | 0.75 | 0.05 | 0.27 | 0.00 | 0.00 | 0.00 | 0.18 | 0.00 | 0.02 | 0.02 | 0.09 | 0.04 | 0.00 | 0.02 | 0.16 | 0.02 |
| KCNJ15 | ENSG00000157551 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.02 | 0.06 | 0.04 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 | 0.03 | 0.05 | 0.02 | 0.04 | 0.04 | 0.09 | 0.04 | 0.07 | 0.01 | 0.02 | 0.02 | 0.08 | 0.01 | 0.01 | 0.01 | 0.01 | 0.07 | 0.03 | 0.00 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.08 | 0.01 | 0.13 | 0.10 | 0.07 | 0.01 | 0.04 | 0.01 | 0.04 | 0.03 | 0.07 | 0.07 | 0.04 | 0.00 | 0.16 | 0.00 | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.02 | 0.03 | 0.00 | 0.01 | 0.02 |
| KLK4 | ENSG00000167749 | 0.00 | 0.00 | 0.00 | 0.02 | 0.03 | 0.00 | 0.02 | 0.01 | 0.13 | 0.04 | 0.00 | 0.00 | 0.00 | 0.06 | 0.02 | 0.08 | 0.07 | 0.10 | 0.03 | 0.02 | 0.06 | 0.03 | 0.09 | 0.03 | 0.02 | 0.03 | 0.02 | 0.04 | 0.04 | 0.04 | 0.04 | 0.03 | 0.00 | 0.07 | 0.23 | 0.02 | 0.00 | 0.03 | 0.00 | 0.00 | 0.10 | 0.03 | 0.10 | 0.30 | 0.06 | 0.07 | 0.04 | 0.05 | 0.24 | 0.13 | 0.03 | 0.17 | 0.00 | 0.04 | 0.01 | 0.00 | 0.13 | 0.03 | 0.01 | 0.15 | 0.01 | 0.14 | 0.00 | 0.00 | 0.03 | 0.03 |
| STAT6 | ENSG00000166888 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.06 | 0.03 | 0.00 | 0.00 | 0.02 | 0.02 | 0.12 | 0.01 | 0.03 | 0.01 | 0.03 | 0.02 | 0.12 | 0.04 | 0.11 | 0.02 | 0.02 | 0.00 | 0.02 | 0.01 | 0.02 | 0.01 | 0.06 | 0.01 | 0.06 | 0.01 | 0.19 | 0.03 | 0.06 | 0.00 | 0.00 | 0.00 | 0.04 | 0.04 | 0.15 | 0.04 | 0.05 | 0.00 | 0.04 | 0.01 | 0.14 | 0.06 | 0.31 | 0.07 | 0.01 | 0.00 | 0.00 | 0.00 | 0.12 | 0.00 | 0.03 | 0.02 | 0.11 | 0.05 | 0.00 | 0.00 | 0.10 | 0.03 |
| PTPRZ1 | ENSG00000106278 | 0.01 | 0.01 | 0.08 | 0.00 | 0.01 | 0.00 | 0.02 | 0.03 | 0.04 | 0.04 | 0.00 | 0.01 | 0.05 | 0.05 | 0.07 | 0.02 | 0.10 | 0.06 | 0.04 | 0.11 | 0.05 | 0.17 | 0.08 | 0.06 | 0.02 | 0.00 | 0.00 | 0.02 | 0.01 | 0.04 | 0.08 | 0.03 | 0.00 | 0.02 | 0.00 | 0.06 | 0.00 | 0.02 | 0.00 | 0.00 | 0.06 | 0.04 | 0.31 | 0.07 | 0.03 | 0.06 | 0.02 | 0.05 | 0.05 | 0.12 | 0.11 | 0.03 | 0.03 | 0.02 | 0.00 | 0.03 | 0.09 | 0.07 | 0.10 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.17 | 0.02 |
| LAMC2 | ENSG00000058085 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.03 | 0.24 | 0.02 | 0.02 | 0.00 | 0.10 | 0.03 | 0.10 | 0.00 | 0.15 | 0.01 | 0.05 | 0.00 | 0.15 | 0.02 | 0.10 | 0.00 | 0.03 | 0.00 | 0.14 | 0.00 | 0.04 | 0.00 | 0.15 | 0.02 | 0.20 | 0.01 | 0.02 | 0.05 | 0.02 | 0.00 | 0.01 | 0.00 | 0.17 | 0.01 | 0.42 | 0.03 | 0.08 | 0.01 | 0.12 | 0.00 | 0.50 | 0.00 | 0.30 | 0.03 | 0.07 | 0.00 | 0.01 | 0.00 | 0.30 | 0.02 | 0.01 | 0.01 | 0.02 | 0.00 | 0.04 | 0.00 | 0.11 | 0.02 |
| PLAT | ENSG00000104368 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.09 | 0.25 | 0.05 | 0.00 | 0.00 | 0.02 | 0.00 | 0.21 | 0.04 | 0.42 | 0.03 | 0.12 | 0.03 | 0.44 | 0.07 | 0.09 | 0.03 | 0.20 | 0.02 | 0.18 | 0.03 | 0.03 | 0.00 | 0.06 | 0.04 | 0.00 | 0.02 | 0.09 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.42 | 0.05 | 0.37 | 0.04 | 0.08 | 0.02 | 0.24 | 0.01 | 0.80 | 0.07 | 0.14 | 0.07 | 0.02 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.05 | 0.02 |
|
Showing page 181 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.