Copy Number

 

The putative cancer-causing CDKs/Cyclins driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the CDKs/Cyclins in each cancer type


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HGNC Ensembl ACCBLCABRCACESCCHOLCOADDLBCESCAGBMHNSCKICHKIRCKIRPLAMLLGGLIHCLUADLUSCMESOOVPAADPCPGPRADREADSARCSKCMSTADTGCTTHCATHYMUCECUCSUVM
 Symbol  Gene ID  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del 
CDK20  ENSG00000156345    0.02    0    0.05    0.03    0.03    0.03    0    0.02    0    0.15    0.02    0.01    0.05    0.02    0.06    0.01    0.03    0.02    0.02    0    0    0    0    0    0    0.01    0    0.02    0    0    0.01    0.02    0.02    0.03    0.03    0.02    0.01    0.05    0.05    0.13    0    0    0    0.02    0    0.02    0.02    0.01    0.1    0.01    0.01    0.02    0.03    0.05    0.04    0.02    0    0    0    0.02    0.04    0.03    0.03    0.15    0    0  
CCNA1  ENSG00000133101    0    0.03    0.07    0.15    0.06    0.11    0.02    0.19    0    0.14    0.13    0.02    0    0.06    0.05    0.09    0    0.1    0.02    0.16    0    0    0.02    0.02    0    0.01    0    0    0.01    0.06    0.01    0.19    0.02    0.09    0.02    0.11    0    0.18    0.05    0.2    0.01    0.01    0.01    0    0.01    0.24    0.16    0.02    0.1    0.27    0.04    0.03    0.15    0.03    0    0.02    0    0.01    0    0.02    0.02    0.05    0.07    0.23    0    0  
CCNA2  ENSG00000145386    0.11    0.05    0.05    0.07    0.05    0.04    0.01    0.04    0    0.11    0.01    0.04    0    0.05    0.01    0.04    0.01    0.01    0.03    0.02    0    0    0    0.02    0    0.01    0    0    0.01    0.04    0.05    0.07    0.02    0.04    0.02    0.06    0    0.04    0.05    0.24    0    0.02    0    0.01    0.01    0.07    0.01    0.02    0.07    0.07    0.01    0.03    0.02    0.06    0    0.01    0    0    0    0    0.01    0.04    0.07    0.07    0    0  
CCNB1  ENSG00000134057    0.07    0.01    0.01    0.15    0.02    0.1    0    0.07    0    0.13    0.01    0.07    0    0    0.01    0.16    0.01    0.03    0.01    0.07    0.03    0.01    0    0.01    0    0.01    0    0.01    0    0.01    0    0.04    0    0.08    0.01    0.09    0    0.05    0.01    0.72    0    0.07    0.01    0.03    0    0.22    0    0.09    0.02    0.05    0.03    0.04    0.01    0.14    0.01    0    0    0    0    0.01    0.01    0.11    0    0.35    0    0  
CCNB2  ENSG00000157456    0.04    0.03    0.03    0.05    0.03    0.06    0.03    0.06    0    0.01    0.01    0.04    0.06    0.02    0.05    0.06    0.01    0.05    0.01    0.03    0.14    0.02    0    0    0    0.01    0    0    0.01    0.02    0.02    0.01    0.02    0.04    0.03    0.04    0.08    0.02    0.05    0.14    0.01    0.02    0    0.01    0.01    0.03    0    0.06    0.1    0.02    0.04    0.06    0.02    0.06    0.01    0.02    0    0    0    0    0.01    0.07    0    0.26    0    0  
CCNC  ENSG00000112237    0.07    0.02    0.01    0.09    0.07    0.1    0.02    0.01    0    0.11    0    0.03    0    0.26    0.04    0.1    0    0.04    0.02    0.03    0    0    0    0.03    0    0    0    0    0    0.01    0.02    0.07    0.01    0.05    0.02    0.04    0    0.09    0.16    0.16    0.02    0.03    0    0    0.01    0.34    0.01    0.04    0.13    0.12    0.01    0.08    0.04    0.08    0    0.01    0    0    0    0.01    0.03    0.02    0.06    0.05    0.05    0.02  
CCND1  ENSG00000110092    0.06    0.01    0.86    0.01    1.31    0.02    0.28    0.01    0.76    0.02    0.02    0.01    0    0.02    2.79    0    0.01    0.03    1.9    0.01    0.09    0    0.01    0    0.03    0.01    0    0    0.01    0.01    0.55    0.01    0.23    0    1.1    0.01    0.08    0    0.43    0.04    0.04    0.01    0.02    0    0.1    0    0.07    0.02    0.21    0.05    0.44    0.01    0.44    0.02    0    0.05    0    0    0    0    0.16    0.02    0.19    0.11    0    0  
CCND2  ENSG00000118971    0.07    0    0.11    0.04    0.13    0.04    0.05    0.02    0.14    0.05    0.17    0.01    0.02    0.03    0.11    0.03    0.2    0.02    0.15    0.01    0.02    0    0.01    0    0    0.01    0    0.01    0.19    0    0.03    0.04    0.06    0.07    0.19    0.01    0.02    0.01    0.41    0.08    0.1    0.05    0.01    0.01    0.02    0.06    0.15    0.05    0.19    0.11    0.05    0.04    0.06    0.06    0.57    0    0    0    0.01    0    0.07    0.02    0.34    0.02    0    0.01  
CCND3  ENSG00000112576    0.09    0    0.17    0.03    0.14    0.03    0.06    0.02    0.05    0.01    0.12    0    0.14    0    0.5    0.02    0.03    0.01    0.07    0.02    0    0    0.01    0    0.01    0    0    0    0.01    0    0.1    0.01    0.17    0.01    0.15    0.05    0    0.02    0.3    0.05    0.05    0    0    0    0.02    0.01    0.16    0    0.28    0.03    0.05    0    0.38    0    0.07    0.01    0    0    0    0    0.06    0.01    0.22    0.03    0.02    0  
CCNE1  ENSG00000105173    0.32    0.02    0.45    0.01    0.23    0.02    0.1    0    0.12    0.01    0.08    0    0.07    0    0.55    0.03    0.09    0.02    0.09    0.02    0.02    0    0    0    0    0    0    0    0.01    0.01    0.13    0.01    0.27    0.02    0.46    0.02    0.16    0.02    1.48    0.02    0.19    0    0    0    0.01    0.01    0.02    0.01    0.55    0    0.05    0.02    0.86    0.02    0.01    0.01    0    0    0    0    0.55    0    2.49    0    0    0  
CCNE2  ENSG00000175305    0.07    0    0.25    0.01    0.41    0    0.09    0    0.19    0.01    0.09    0    0.04    0.02    0.19    0.01    0.02    0.01    0.09    0.01    0.14    0    0    0    0.02    0    0    0    0.09    0    0.25    0.01    0.15    0.01    0.17    0.02    0.02    0.01    0.5    0.07    0.04    0.01    0    0.01    0.07    0.02    0.17    0.03    0.16    0.04    0.11    0.01    0.16    0    0.16    0    0    0    0.02    0    0.11    0.02    0.25    0.02    0.39    0  
CCNY  ENSG00000108100    0.03    0.04    0.05    0.05    0.06    0.03    0.01    0.01    0.04    0.01    0.01    0    0    0    0.18    0.02    0    0.01    0.06    0.02    0    0    0.01    0    0    0    0    0    0.01    0.01    0.04    0.01    0.08    0.01    0.07    0.01    0.06    0.02    0.2    0.04    0.05    0    0    0    0.01    0.02    0.01    0    0.05    0.03    0.02    0.02    0.09    0.01    0    0    0    0    0    0.01    0.05    0.01    0.11    0    0    0  
CDK5R1  ENSG00000176749    0.01    0.07    0.23    0.02    0.17    0.08    0.01    0.02    0.08    0.01    0.05    0.01    0.04    0    0.17    0    0.01    0.03    0.04    0.02    0    0    0    0    0.01    0    0    0.01    0    0.02    0.05    0.03    0.07    0.01    0.05    0.03    0    0.05    0.04    0.19    0.08    0.02    0    0.18    0    0.02    0.07    0.01    0.04    0.16    0.03    0.03    0.15    0.01    0    0.01    0    0    0.01    0.01    0.06    0.06    0.15    0.07    0    0.03  
CDK5R2  ENSG00000171450    0.04    0.02    0.01    0.27    0.04    0.06    0.03    0.34    0    0.01    0.02    0.01    0    0.04    0.03    0.11    0    0    0    0.18    0    0.03    0.01    0.06    0.04    0.04    0    0    0    0.02    0.03    0.04    0.02    0.03    0.04    0.19    0    0.1    0.18    0.16    0.05    0.03    0    0    0.01    0.02    0.02    0.02    0.08    0.19    0.03    0.03    0.06    0.03    0.08    0.01    0    0.01    0    0.01    0.06    0.04    0.16    0.05    0.02    0.02  
CCNH  ENSG00000134480    0.06    0.03    0.01    0.09    0.01    0.08    0    0.06    0    0.08    0    0.09    0    0    0.01    0.15    0.01    0.01    0    0.08    0.05    0.01    0.01    0.01    0.01    0.01    0    0.05    0.01    0.02    0.02    0.05    0.01    0.08    0    0.11    0    0.04    0.04    0.64    0    0.07    0.01    0.05    0    0.13    0.01    0.03    0.03    0.05    0.06    0.04    0    0.14    0    0    0    0    0    0.01    0    0.08    0    0.21    0    0  
CCNL1  ENSG00000163660    0.1    0.01    0.12    0.01    0.15    0.01    0.49    0.01    0.03    0.01    0.02    0    0.01    0.02    0.64    0.02    0.02    0.04    0.47    0    0    0    0.04    0.01    0.01    0.01    0    0    0.01    0.01    0.08    0.01    0.13    0.01    0.92    0.01    0    0.04    0.71    0.02    0.03    0    0    0.06    0.04    0.01    0.05    0.01    0.05    0.07    0.01    0.03    0.16    0.01    0.11    0    0    0    0    0    0.15    0.01    0.21    0.02    0    0  
CCNL2  ENSG00000221978    0.05    0.17    0.1    0.08    0.04    0.19    0.06    0.11    0    1.01    0.02    0.11    0    0.19    0.13    0.08    0.03    0.15    0.06    0.09    0    0    0    0.05    0.01    0.1    0.02    0    0    0.03    0.02    0.31    0.09    0.06    0.08    0.11    0.04    0.27    0.23    0.38    0.05    0.05    0.01    0.12    0.02    0.03    0    0.17    0.18    0.28    0.07    0.13    0.09    0.09    0.1    0.12    0    0    0    0.02    0.05    0.12    0.08    0.27    0    0.14  
CCNT1  ENSG00000129315    0.16    0.01    0.03    0.03    0.03    0.05    0.02    0    0.09    0.01    0.02    0    0.1    0.06    0.06    0.04    0.03    0.05    0.01    0.04    0    0    0    0    0    0    0    0.01    0.01    0.04    0.01    0.01    0.06    0.02    0.04    0.02    0    0.04    0.08    0.06    0    0.04    0    0.03    0    0.01    0.02    0.02    0.07    0.08    0.09    0.04    0.05    0.04    0.02    0    0    0    0    0    0.03    0.01    0.13    0.13    0    0  
CCNT2  ENSG00000082258    0.05    0.02    0.06    0.03    0.02    0.06    0.04    0.01    0.05    0.03    0    0.02    0    0.14    0.08    0.07    0.01    0.01    0.04    0.01    0    0    0    0    0.01    0    0    0    0    0.01    0.02    0.04    0.03    0.01    0.06    0.03    0    0    0.09    0.16    0.01    0.01    0    0    0    0.19    0.02    0.01    0.1    0.04    0.01    0    0.04    0.06    0.01    0.01    0    0    0    0.01    0.02    0.01    0.09    0    0    0  
CCNK  ENSG00000090061    0.05    0    0.07    0.06    0.05    0.07    0.06    0.1    0    0.31    0    0.03    0    0.03    0.08    0.05    0.02    0.06    0.07    0.05    0    0.04    0    0.02    0.01    0.02    0    0    0    0.08    0    0.11    0.04    0.06    0.18    0.02    0    0.09    0.21    0.17    0.01    0.02    0.01    0.02    0.01    0.04    0.01    0.02    0.12    0.06    0.01    0.06    0.03    0.07    0.03    0.01    0    0    0    0    0.03    0.02    0.2    0.02    0.03    0.01  

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