Copy Number

 

The putative cancer-causing CDKs/Cyclins driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).

 

Summary of the G-score of the CDKs/Cyclins in each cancer type


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HGNC Ensembl ACCBLCABRCACESCCHOLCOADDLBCESCAGBMHNSCKICHKIRCKIRPLAMLLGGLIHCLUADLUSCMESOOVPAADPCPGPRADREADSARCSKCMSTADTGCTTHCATHYMUCECUCSUVM
 Symbol  Gene ID  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del  Amp  Del 
CDK1  ENSG00000170312    0    0    0.03    0.04    0.14    0.03    0.02    0.01    0.31    0.01    0.01    0.03    0.03    0    0.08    0.07    0.01    0.01    0.06    0.02    0.03    0    0    0.01    0    0.01    0    0    0.01    0    0.03    0.02    0.06    0.02    0.07    0.04    0.01    0.04    0.13    0.11    0.01    0    0    0    0.03    0.04    0    0.02    0.03    0.08    0.01    0.04    0.09    0.02    0    0.01    0    0.01    0    0    0.09    0.03    0.56    0.03    0    0  
CDK2  ENSG00000123374    0.08    0.01    0.07    0.03    0.04    0.05    0.03    0    0    0.01    0.02    0    0.12    0    0.08    0.03    0.03    0.05    0.01    0.02    0    0    0    0    0    0    0    0    0.02    0.03    0.06    0    0.11    0.01    0.04    0.02    0.02    0.02    0.26    0.04    0.02    0.01    0.06    0    0.02    0.01    0.02    0.01    0.21    0.07    0.05    0.03    0.17    0.01    0.01    0    0    0    0    0    0.15    0    0.21    0.07    0    0  
CDK3  ENSG00000250506    0.16    0.02    0.22    0    0.37    0.03    0.24    0.03    0.08    0.01    0.04    0.01    0.02    0    0.19    0.07    0.05    0.01    0.09    0.03    0.02    0    0.02    0    0.05    0    0    0    0.09    0    0.25    0    0.15    0.02    0.24    0.01    0.09    0.02    0.35    0.04    0.04    0.1    0.02    0.01    0.04    0.03    0.06    0.03    0.24    0.02    0.24    0.02    0.06    0.04    0.04    0    0    0    0    0.01    0.17    0.02    0.61    0.04    0.14    0.01  
CDK4  ENSG00000135446    0.44    0.02    0.11    0.03    0.14    0.03    0.03    0    0.31    0.01    0.01    0    0.12    0    0.11    0.04    1.24    0.02    0.04    0.02    0    0    0    0    0    0    0    0    0.38    0.01    0.09    0.01    0.33    0    0.08    0.01    0.02    0.02    0.16    0.05    0.04    0.02    0.07    0    0.01    0.01    0.04    0.01    1.74    0.07    0.28    0.03    0.18    0.01    0    0    0    0    0    0    0.02    0.01    0.1    0.05    0    0  
CDK5  ENSG00000164885    0.07    0.07    0.05    0.05    0.07    0.07    0.04    0.09    0    0.11    0.02    0.01    0.02    0.09    0.04    0.25    0.07    0.01    0.02    0.17    0.09    0    0.03    0.01    0.04    0    0    0.06    0.1    0.01    0.07    0.04    0.1    0.02    0.1    0.09    0    0.03    0.53    0.08    0.02    0.05    0    0.03    0.03    0.03    0.01    0.02    0.1    0.15    0.2    0.03    0.03    0.1    0.01    0.05    0    0    0    0.01    0.03    0.06    0.08    0.19    0    0.03  
CDK6  ENSG00000105810    0.11    0.01    0.07    0.02    0.07    0.02    0.06    0.04    0.18    0.01    0.04    0.01    0.13    0    0.76    0.01    0.17    0    0.27    0.01    0    0    0.01    0    0.07    0    0    0.01    0.05    0    0.13    0.02    0.1    0.01    0.28    0.01    0.03    0    0.16    0.06    0.13    0    0    0.02    0.05    0.01    0.01    0.01    0.16    0.03    0.03    0.02    0.55    0.01    0.13    0    0    0    0    0    0.04    0.02    0.08    0.05    0    0  
CDK14  ENSG00000058091    0.11    0.01    0.06    0.02    0.07    0.02    0.07    0.01    0.18    0.01    0.03    0.01    0.13    0    0.61    0.02    0.07    0.01    0.18    0.01    0    0    0.01    0    0.04    0    0    0.01    0.02    0    0.12    0.03    0.07    0.01    0.25    0.02    0.03    0.02    0.17    0.09    0.12    0.01    0    0.02    0.05    0.01    0.02    0    0.13    0.05    0.04    0.03    0.38    0.03    0.13    0    0    0    0    0    0.04    0.02    0.11    0.03    0    0  
CDK15  ENSG00000138395    0.02    0    0.01    0.13    0.04    0.04    0.09    0.18    0    0.01    0.02    0    0    0.04    0.09    0.04    0    0    0.1    0.11    0    0.01    0.03    0.02    0.04    0.02    0    0    0    0.01    0.06    0.01    0.04    0.02    0.15    0.07    0    0.05    0.25    0.08    0.07    0.01    0    0    0.01    0.03    0.03    0    0.1    0.11    0.02    0.02    0.07    0.04    0.06    0    0    0    0.02    0    0.06    0.02    0.09    0.05    0.02    0.02  
CDK16  ENSG00000102225    0.16    0    0.05    0.03    0.08    0.01    0.03    0.03    0    0.01    0    0    0.07    0    0.04    0.03    0    0    0.03    0.02    0    0    0.01    0    0.01    0    0    0    0.01    0    0.01    0    0.08    0.02    0.05    0.02    0    0    0.39    0.06    0.01    0    0.01    0    0.03    0    0.01    0.02    0.13    0.01    0.01    0    0.03    0.01    0.01    0    0    0    0    0    0.14    0.01    0.39    0.05    0.03    0  
CDK17  ENSG00000059758    0.01    0.01    0.08    0.04    0.07    0.06    0.01    0.02    0    0.17    0    0.02    0.08    0.02    0.06    0.06    0.01    0.03    0.02    0.03    0.06    0.03    0.01    0.01    0.01    0    0    0    0    0.02    0.03    0.03    0.02    0.05    0.03    0.03    0.02    0.03    0.06    0.22    0.01    0.06    0    0.03    0.05    0.01    0.01    0.04    0.68    0.05    0.03    0.08    0.05    0.03    0    0    0    0    0    0    0.02    0.03    0.01    0.09    0.02    0  
CDK18  ENSG00000117266    0.03    0.02    0.06    0.05    0.28    0.01    0.07    0    0.18    0.02    0.04    0    0.21    0.04    0.17    0.07    0.11    0.02    0.05    0    0    0    0.02    0    0    0.01    0.01    0    0    0.01    0.2    0.01    0.14    0.01    0.09    0.01    0.12    0    0.29    0.08    0    0    0.01    0    0.02    0.01    0.12    0.02    0.06    0.17    0.19    0.02    0.06    0.01    0.05    0.02    0    0    0.01    0    0.15    0.01    0.22    0    0.09    0  
CDK7  ENSG00000134058    0.07    0.01    0.01    0.15    0.02    0.1    0    0.07    0    0.13    0.01    0.07    0    0    0.01    0.16    0.01    0.03    0.01    0.07    0.03    0.01    0    0.01    0    0.01    0    0.01    0    0.01    0.01    0.04    0    0.08    0.01    0.09    0    0.05    0.01    0.72    0    0.07    0.01    0.03    0    0.21    0    0.09    0.02    0.05    0.04    0.04    0.01    0.14    0    0    0    0    0    0.01    0.01    0.11    0    0.35    0    0  
CDK8  ENSG00000132964    0    0.09    0.11    0.05    0.1    0.06    0.03    0.13    0    0.15    0.25    0    0    0.09    0.08    0.09    0.01    0.06    0.03    0.13    0    0    0.01    0.02    0    0    0    0    0.01    0.06    0.03    0.11    0.02    0.1    0.03    0.11    0    0.18    0.07    0.18    0    0    0    0    0.03    0.02    0.35    0.02    0.13    0.22    0.06    0.03    0.09    0.04    0    0.03    0    0.01    0    0.02    0.01    0.05    0.01    0.16    0    0  
CDK9  ENSG00000136807    0.14    0.04    0.03    0.02    0.09    0.03    0.05    0.01    0.07    0.04    0.01    0.01    0.05    0    0.12    0.02    0.03    0.02    0.06    0.01    0    0    0    0    0.01    0    0.01    0    0.02    0    0.05    0.03    0.04    0.02    0.06    0.02    0    0.02    0.1    0.17    0    0.01    0    0    0.05    0    0.04    0.02    0.04    0.07    0.05    0.02    0.1    0.01    0.02    0.04    0    0    0    0.01    0.08    0.04    0.15    0.11    0    0  
CDK10  ENSG00000185324    0.07    0.06    0.08    0.06    0.05    0.1    0.05    0.07    0.05    0.05    0.02    0.03    0.03    0    0.08    0.05    0.01    0.05    0.03    0.05    0    0.06    0    0    0.01    0.04    0    0.04    0    0.02    0.02    0.08    0.01    0.12    0.04    0.07    0.02    0.19    0.08    0.35    0.02    0.01    0    0.02    0.01    0.23    0.03    0.04    0.09    0.07    0.02    0.11    0.05    0.05    0    0.12    0    0.01    0    0    0.01    0.09    0.03    0.29    0    0.06  
CDK11A  ENSG00000008128    0.05    0.17    0.1    0.08    0.04    0.19    0.06    0.11    0    1.01    0.02    0.11    0    0.19    0.13    0.08    0.03    0.15    0.06    0.09    0    0    0    0.05    0.01    0.1    0.02    0    0    0.03    0.02    0.31    0.09    0.06    0.08    0.11    0.04    0.27    0.23    0.38    0.05    0.05    0.01    0.12    0.02    0.03    0    0.17    0.18    0.28    0.07    0.13    0.09    0.09    0.1    0.12    0    0    0    0.02    0.05    0.12    0.08    0.27    0    0.14  
CDK11B  ENSG00000248333    0.05    0.17    0.1    0.08    0.04    0.19    0.06    0.11    0    1.01    0.02    0.11    0    0.19    0.13    0.08    0.03    0.15    0.06    0.09    0    0    0    0.05    0.01    0.1    0.02    0    0    0.03    0.02    0.31    0.09    0.06    0.08    0.11    0.04    0.27    0.23    0.38    0.05    0.05    0.01    0.12    0.02    0.03    0    0.17    0.18    0.28    0.07    0.13    0.09    0.09    0.1    0.12    0    0    0    0.02    0.05    0.12    0.08    0.27    0    0.14  
CDK12  ENSG00000167258    0.03    0.17    0.23    0.01    0.86    0.07    0.17    0.02    0.02    0.01    0.2    0.01    0.04    0    0.94    0.02    0.01    0.04    0.15    0.01    0    0    0    0    0    0    0.01    0.02    0    0.01    0.02    0.05    0.16    0.01    0.15    0.04    0.01    0.04    0.13    0.16    0.1    0.02    0    0.12    0.02    0.03    0.22    0.02    0.05    0.14    0.02    0.03    0.74    0.01    0.01    0.01    0    0    0    0.01    0.35    0.06    0.56    0.07    0    0.05  
CDK13  ENSG00000065883    0.13    0    0.07    0.02    0.06    0.02    0.01    0    0    0.01    0.03    0    0    0.02    0.1    0.04    0.03    0    0.04    0.01    0    0    0.01    0    0.01    0.01    0    0.02    0.01    0    0.01    0.01    0.03    0.01    0.04    0.03    0    0    0.1    0.08    0    0    0    0    0.01    0.01    0    0    0.07    0.03    0.04    0.03    0.02    0    0.04    0    0.01    0    0    0    0.05    0.01    0.09    0.03    0    0  
CDK19  ENSG00000155111    0.05    0.02    0.03    0.12    0.12    0.09    0.02    0.02    0    0.15    0.01    0.03    0.01    0.21    0.04    0.08    0.02    0.06    0.02    0.03    0    0    0    0.04    0    0    0    0    0    0.02    0.01    0.08    0.02    0.06    0.03    0.05    0    0.14    0.08    0.26    0    0.03    0    0    0.01    0.3    0.01    0.04    0.23    0.08    0    0.13    0.05    0.07    0    0.04    0    0    0    0.01    0.09    0.02    0.15    0.04    0.04    0.03  

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