Mutation

 

The putative cancer-causing HAMPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the HAMPs in each cancer type


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 HGNC Symbol  Ensembl Gene ID  ACC  BLCA  BRCA  CESC  CHOL  COAD  DLBC  ESCA  GBM  HNSC  KICH  KIRC  KIRP  LAML  LGG  LIHC  LUAD  LUSC  MESO  OV  PAAD  PCPG  PRAD  READ  SARC  SKCM  STAD  TGCT  THCA  THYM  UCEC  UCS  UVM 
SP100  ENSG00000067066                1                                                                                                            1          
SP110  ENSG00000135899                                                                                                                                      
TRIM28  ENSG00000130726                                                                                                                                      
TRIM33  ENSG00000197323                                                                                                                            1          
TRIM24  ENSG00000122779                                                                                                                                      
TRIM66  ENSG00000166436                                                                                                                                      
BAZ1A  ENSG00000198604                                                                                                        1                              
SMARCA2  ENSG00000080503        1                                                                                                                    1          
SMARCA4  ENSG00000127616                        1                1            1                1    1                                                              
ASH1L  ENSG00000116539                                                                                                        1                    1          
BAZ1B  ENSG00000009954                1                                                                                                                      
PBRM1  ENSG00000163939                    1                            1                    1                                                        1          
ZMYND8  ENSG00000101040                                                                                                                                      
ZMYND11  ENSG00000015171                                                                                                                                      
BRD4  ENSG00000141867                1                                                                                                                      
BPTF  ENSG00000171634                                                                        1                                1                    1          
BRD2  ENSG00000204256                        1                                                                                                              
BRDT  ENSG00000137948                                                                                                                                      
BRD3  ENSG00000169925                                                                                                                                      
KMT2A  ENSG00000118058        1                                                                1                                                    1          

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