Mutation

 

The putative cancer-causing HAMPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Summary of mutation frequency of the HAMPs in each cancer type


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 Symbol  Gene ID  ACC_Mut%  BLCA_Mut%  BRCA_Mut%  CESC_Mut%  CHOL_Mut%  COAD_Mut%  DLBC_Mut%  ESCA_Mut%  GBM_Mut%  HNSC_Mut%  KICH_Mut%  KIRC_Mut%  KIRP_Mut%  LAML_Mut%  LGG_Mut%  LIHC_Mut%  LUAD_Mut%  LUSC_Mut%  MESO_Mut%  OV_Mut%  PAAD_Mut%  PCPG_Mut%  PRAD_Mut%  READ_Mut%  SARC_Mut%  SKCM_Mut%  STAD_Mut%  TGCT_Mut%  THCA_Mut%  THYM_Mut%  UCEC_Mut%  UCS_Mut%  UVM_Mut% 
HDAC10  ENSG00000100429    0    0.73    0.2    0.35    0    0.99    0    0    0    0.79    0    0.27    0.36    0    0.39    0    0.53    1.03    0    0    0    0    0.2    0.67    0    0.86    1.14    0.69    0    0    3.77    1.75    0  
HDAC6  ENSG00000094631    2.17    1.95    1.27    2.42    0    2.71    0    1.63    0.76    1.18    0    0.54    0.71    0    0.59    0.83    2.29    1.86    0    1.21    0.56    0    0.4    1.33    0.85    1.07    2.05    0    0    0    10.94    3.51    0  
HDAC7  ENSG00000061273    1.09    0.49    0.1    1.38    0    2.22    0    0    0.25    1.18    1.52    0.27    0.71    0    0.2    0.28    0.71    0.82    0    0.49    0.56    0    0.2    1.33    0.85    1.93    3.42    0    0    0    3.96    3.51    0  
HDAC4  ENSG00000068024    1.09    0.73    0.69    1.04    0    4.43    0    3.26    1.02    1.78    0    0.27    0    0.71    0.78    1.65    3.17    3.09    0    0.97    0.56    0    0.2    0    0    2.79    5.69    0    0    0    9.62    0    0  
HDAC5  ENSG00000108840    0    1.22    0.59    2.08    0    3.2    0    1.09    1.02    0.39    1.52    0    1.07    0    0.2    0.83    0.53    0.62    0    0    1.13    0    0.8    0.67    0.42    2.15    2.51    0    0    0    5.85    0    2.5  
HDAC9  ENSG00000048052    1.09    1.7    0.49    1.73    2.78    5.91    2.7    4.35    1.27    3.16    1.52    0.81    0.36    0    0.2    2.48    8.11    5.98    0    0.73    1.69    0    0.4    5.33    0.42    12.88    2.73    0    0    0    6.23    0    0  
SIRT6  ENSG00000077463    0    0.49    0.29    0.35    0    1.23    0    0.54    0    0    0    0.54    0    0.71    0    0    0.35    0.82    0    0    0    0    0    0    0    0.43    0.46    0    0    0    0.94    0    0  
SIRT3  ENSG00000142082    0    0.49    0.2    0.35    0    0.99    0    0.54    0.51    0.39    1.52    0    0    0    0.39    0.28    0.35    0.41    0    0.24    0    0    0.2    0    0.85    0.43    0    0    0    0    2.26    0    0  
SIRT1  ENSG00000096717    1.09    2.19    0.39    0.69    0    1.97    0    0.54    0.25    0.39    0    0.81    0    0.71    0.2    0.28    0.35    0.41    0    0.24    0.56    0    0.6    2    0.42    0.64    1.82    0    0    0    4.91    1.75    0  
SIRT2  ENSG00000068903    0    0.49    0.29    0.69    0    0.25    0    0    0.51    0.2    0    0    0    0.71    0    0.55    0.35    1.44    0    0.24    0    0    0.2    0.67    0.42    0.43    0.68    0    0    0    2.26    1.75    0  
SIRT7  ENSG00000187531    0    0.97    0.29    0.69    0    0.99    0    0.54    0.51    0.2    0    0.81    0.71    0    0.2    0    0.71    0.62    0    0    0    0    0    0    0.42    0.64    0.91    0    0    0    1.89    0    0  
SIRT4  ENSG00000089163    0    0.24    0.1    0.35    0    1.48    2.7    0    0.51    0.39    0    0.27    0    0    0.2    0.28    0.53    0.62    0    0.24    0    0    0.2    0.67    0    0.86    0.46    0    0.2    0    3.02    0    0  
SIRT5  ENSG00000124523    0    0.73    0.1    1.04    0    0.99    0    0    0.25    0.39    0    0    0    0    0.39    0    0.18    0.21    0    0.24    0    0    0    0.67    0    1.29    0.91    0.69    0    0    3.77    0    0  

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