protein kinase, membrane associated tyrosine/threonine 1
Location:
16p13.3
Also known as:
MYT1, PPP1R126
Entrez ID:
9088
Ensembl ID:
ENSG00000127564
Summary:
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Overall distribution
Tissue specific distribution
Expression restricted in 9 cancer type(s)
Cancer specific in breast cancer subtype (Basal; Her2; TNBC)
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.00
Gscore (Del):
0.00
Overall distribution
Tissue specific distribution
Mscore:
0.00
Overall
Tissue specific
Total fusion occurrence:
3
Fusions detected in 3 cancer type(s)
Overall
Tissue specific
CRISPR: COMMON ESSENTIAL
Functional class:
Kinase (protein kinase)
JensenLab PubMed score:
19.16 (Percentile rank: 46.69%)
PubTator score:
13.53 (Percentile rank: 45.32%)
Target development/druggability level:
TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
Tractability (small molecule):
Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
