Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
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| HGNC Symbol | Ensembl Gene ID | Overall_Mscore | No. of Cancer Types |
| TPH2 | ENSG00000139287 | 0.00 | 0 |
| NTS | ENSG00000133636 | 0.00 | 0 |
| LTA4H | ENSG00000111144 | 0.00 | 0 |
| NR1H4 | ENSG00000012504 | 0.00 | 0 |
| PAH | ENSG00000171759 | 0.00 | 0 |
| PTPN11 | ENSG00000179295 | 0.25 | 4 |
| KSR2 | ENSG00000171435 | 0.00 | 0 |
| PRKAB1 | ENSG00000111725 | 0.00 | 0 |
| HPD | ENSG00000158104 | 0.00 | 0 |
| NCOR2 | ENSG00000196498 | 0.13 | 1 |
| CDK8 | ENSG00000132964 | 0.05 | 1 |
| HSPH1 | ENSG00000120694 | 0.00 | 0 |
| KBTBD6 | ENSG00000165572 | 0.00 | 0 |
| KBTBD7 | ENSG00000120696 | 0.00 | 0 |
| SETDB2 | ENSG00000136169 | 0.00 | 0 |
| GUCY1B2 | ENSG00000123201 | 0.00 | 0 |
| KLHL1 | ENSG00000150361 | 0.00 | 0 |
| KLF5 | ENSG00000102554 | 0.32 | 2 |
| UCHL3 | ENSG00000118939 | 0.00 | 0 |
| STK24 | ENSG00000102572 | 0.00 | 0 |
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