Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| COL17A1 | ENSG00000065618 | 0.00 | 2.29 | 0.93 | 1.46 | 0.00 | 0.32 | 2.70 | 1.10 | 1.55 | 1.99 | 1.54 | 0.27 | 0.71 | 0.00 | 0.20 | 0.83 | 2.45 | 1.29 | 0.00 | 3.19 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 4.74 | 1.90 | 0.00 | 0.00 | 0.83 | 2.22 | 1.82 | 0.00 |
| SLC5A12 | ENSG00000148942 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.32 | 2.70 | 1.66 | 0.77 | 1.20 | 0.00 | 0.81 | 2.49 | 0.00 | 0.00 | 0.83 | 3.01 | 2.15 | 0.00 | 0.98 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| SLC1A2 | ENSG00000110436 | 0.00 | 0.76 | 0.31 | 1.09 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 0.86 | 1.23 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.37 | 0.27 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CD248 | ENSG00000174807 | 2.22 | 0.76 | 0.52 | 0.73 | 0.00 | 1.61 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.61 | 0.00 | 0.00 | 2.13 | 0.27 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| NOX4 | ENSG00000086991 | 0.00 | 1.53 | 0.31 | 0.73 | 2.86 | 2.58 | 8.11 | 3.87 | 1.55 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 2.26 | 4.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 1.56 | 0.00 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| SLC2A14 | ENSG00000173262 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.97 | 2.70 | 1.10 | 1.29 | 1.20 | 0.00 | 1.08 | 0.71 | 0.00 | 0.59 | 0.28 | 1.13 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.81 | 0.00 | 0.20 | 0.83 | 1.77 | 1.82 | 0.00 |
| KLRD1 | ENSG00000134539 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ART4 | ENSG00000111339 | 0.00 | 0.00 | 0.00 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLCO1C1 | ENSG00000139155 | 1.11 | 2.54 | 0.62 | 0.73 | 0.00 | 0.32 | 5.41 | 3.87 | 0.26 | 2.19 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 1.11 | 2.82 | 6.44 | 0.00 | 1.96 | 0.57 | 0.00 | 0.61 | 1.56 | 0.43 | 4.03 | 2.44 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| SLC5A8 | ENSG00000256870 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 1.20 | 0.00 | 0.27 | 0.00 | 1.47 | 0.59 | 0.83 | 1.69 | 4.08 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 6.87 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 3.64 | 0.00 |
| P2RX2 | ENSG00000187848 | 0.00 | 1.53 | 0.52 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 1.36 | 0.36 | 0.00 | 0.20 | 0.28 | 1.13 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLC24A4 | ENSG00000140090 | 1.11 | 1.53 | 0.52 | 0.73 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 1.59 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.83 | 1.69 | 3.22 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.18 | 1.08 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| ABCA3 | ENSG00000167972 | 0.00 | 2.04 | 0.83 | 1.82 | 0.00 | 1.29 | 2.70 | 2.21 | 0.26 | 1.79 | 0.00 | 0.27 | 0.36 | 0.74 | 0.39 | 1.39 | 1.69 | 1.93 | 0.00 | 1.47 | 0.00 | 0.00 | 0.20 | 3.13 | 0.86 | 3.08 | 1.36 | 0.00 | 0.20 | 0.00 | 3.10 | 1.82 | 0.00 |
| CACNG3 | ENSG00000006116 | 0.00 | 1.02 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 1.03 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.78 | 0.00 | 2.64 | 2.36 | 0.00 | 0.74 | 1.15 | 0.00 | 0.00 | 2.34 | 0.86 | 4.03 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| MMP15 | ENSG00000102996 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.65 | 2.70 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.56 | 0.38 | 0.86 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| DPEP2 | ENSG00000167261 | 0.00 | 0.00 | 0.10 | 1.46 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 1.25 |
| CACNG1 | ENSG00000108878 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CD300LB | ENSG00000178789 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.56 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.56 | 0.41 | 0.78 | 0.86 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ZACN | ENSG00000186919 | 1.11 | 0.76 | 0.00 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 1.54 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 1.13 | 0.21 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GRIN3B | ENSG00000116032 | 0.00 | 0.25 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 1.11 | 0.38 | 1.72 | 1.23 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
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