Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ADCY2 | ENSG00000078295 | 2.22 | 4.58 | 0.41 | 1.46 | 0.00 | 2.58 | 8.11 | 1.10 | 0.52 | 4.18 | 0.00 | 0.27 | 0.71 | 0.74 | 0.39 | 2.78 | 6.59 | 5.15 | 0.00 | 2.45 | 0.00 | 0.00 | 0.41 | 2.34 | 1.29 | 1.90 | 3.52 | 0.69 | 0.00 | 0.00 | 2.44 | 3.64 | 0.00 |
| IL31RA | ENSG00000164509 | 0.00 | 1.27 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.11 | 1.69 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 4.74 | 0.27 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| ADGRV1 | ENSG00000164199 | 3.33 | 9.41 | 2.69 | 7.66 | 5.71 | 6.13 | 5.41 | 6.63 | 4.12 | 6.57 | 1.54 | 3.25 | 3.56 | 0.00 | 2.16 | 6.94 | 8.10 | 14.81 | 1.23 | 2.94 | 0.57 | 1.12 | 1.63 | 6.25 | 4.31 | 32.23 | 9.21 | 1.39 | 0.81 | 0.00 | 7.32 | 0.00 | 0.00 |
| DDR1 | ENSG00000204580 | 1.11 | 1.27 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 0.77 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 0.94 | 1.72 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.08 | 1.90 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| TREM1 | ENSG00000124731 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| NCR2 | ENSG00000096264 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GABRR1 | ENSG00000146276 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.28 | 1.51 | 1.29 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.78 | 1.29 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GABRR2 | ENSG00000111886 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 0.24 | 0.54 | 0.00 | 0.20 | 0.00 | 0.00 | 1.82 | 0.00 |
| ABCB5 | ENSG00000004846 | 1.11 | 4.07 | 0.72 | 1.82 | 0.00 | 2.58 | 5.41 | 2.21 | 1.29 | 1.79 | 0.00 | 0.81 | 1.07 | 0.74 | 0.59 | 2.50 | 7.72 | 5.79 | 0.00 | 1.72 | 2.30 | 0.56 | 0.41 | 3.91 | 1.72 | 9.24 | 2.17 | 0.00 | 0.20 | 0.83 | 2.66 | 0.00 | 0.00 |
| SPAM1 | ENSG00000106304 | 0.00 | 0.25 | 0.52 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 1.29 | 0.40 | 1.54 | 1.08 | 0.00 | 0.74 | 0.59 | 0.83 | 3.95 | 2.58 | 0.00 | 1.72 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 5.21 | 1.08 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| CHRNA2 | ENSG00000120903 | 0.00 | 1.27 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 1.47 | 0.00 | 0.56 | 0.94 | 0.21 | 1.23 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.20 | 0.00 | 1.55 | 1.82 | 0.00 |
| CHRNA6 | ENSG00000147434 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 0.28 | 1.13 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 1.90 | 1.90 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| KCNV2 | ENSG00000168263 | 0.00 | 1.27 | 0.21 | 0.73 | 2.86 | 1.29 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 1.08 | 0.36 | 0.00 | 0.20 | 0.83 | 1.51 | 0.86 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 2.34 | 0.43 | 1.18 | 0.81 | 0.00 | 0.20 | 1.65 | 2.22 | 0.00 | 0.00 |
| CNTNAP3 | ENSG00000106714 | 0.00 | 1.78 | 0.83 | 1.82 | 2.86 | 0.97 | 0.00 | 2.76 | 1.03 | 0.60 | 0.00 | 0.81 | 0.71 | 0.74 | 0.20 | 1.39 | 1.13 | 1.07 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.78 | 1.72 | 4.98 | 2.71 | 0.00 | 0.00 | 0.00 | 2.66 | 1.82 | 0.00 |
| MUSK | ENSG00000030304 | 1.11 | 1.78 | 0.41 | 1.09 | 0.00 | 0.65 | 5.41 | 1.10 | 0.52 | 1.39 | 1.54 | 0.81 | 0.00 | 0.00 | 0.39 | 1.67 | 1.51 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 2.34 | 0.00 | 5.92 | 2.71 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| TMEM27 | ENSG00000147003 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PHEX | ENSG00000102174 | 2.22 | 1.02 | 0.31 | 1.82 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 1.11 | 2.64 | 3.00 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 1.90 | 1.08 | 0.69 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| FCRL1 | ENSG00000163534 | 0.00 | 0.76 | 0.52 | 0.73 | 0.00 | 0.65 | 0.00 | 1.66 | 0.00 | 1.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 1.67 | 2.45 | 3.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 4.74 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 1.25 |
| CACNA1S | ENSG00000081248 | 1.11 | 1.78 | 1.03 | 0.36 | 0.00 | 2.26 | 0.00 | 2.21 | 2.32 | 2.39 | 0.00 | 1.90 | 2.14 | 0.74 | 1.18 | 2.78 | 3.20 | 4.94 | 0.00 | 2.45 | 0.57 | 0.00 | 0.81 | 1.56 | 2.16 | 11.14 | 1.90 | 0.00 | 0.20 | 0.00 | 3.77 | 0.00 | 0.00 |
| KCNK2 | ENSG00000082482 | 1.11 | 1.53 | 0.62 | 0.73 | 0.00 | 1.29 | 0.00 | 2.21 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.83 | 4.33 | 1.72 | 0.00 | 0.25 | 0.57 | 0.00 | 0.61 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
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