Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GRIN2C | ENSG00000161509 | 1.11 | 2.29 | 0.41 | 0.00 | 0.00 | 0.97 | 2.70 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 0.83 | 1.13 | 0.86 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SECTM1 | ENSG00000141574 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC14A2 | ENSG00000132874 | 0.00 | 0.76 | 0.10 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 1.29 | 1.39 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.83 | 3.20 | 3.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 2.34 | 0.00 | 5.45 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 3.64 | 0.00 |
| CLEC4M | ENSG00000104938 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| SLC7A9 | ENSG00000021488 | 1.11 | 1.27 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 1.66 | 0.52 | 0.40 | 0.00 | 0.27 | 0.71 | 1.47 | 0.59 | 0.28 | 0.75 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.86 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| KIRREL2 | ENSG00000126259 | 1.11 | 0.76 | 0.41 | 0.36 | 2.86 | 0.32 | 0.00 | 0.55 | 0.52 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 2.26 | 3.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 3.13 | 0.00 | 3.08 | 0.81 | 0.00 | 0.00 | 0.83 | 3.10 | 0.00 | 0.00 |
| SLC3A1 | ENSG00000138079 | 0.00 | 0.25 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 1.66 | 0.52 | 0.20 | 0.00 | 0.81 | 1.07 | 0.00 | 0.00 | 0.00 | 1.51 | 1.72 | 1.23 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| ICOS | ENSG00000163600 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ADAM23 | ENSG00000114948 | 1.11 | 1.53 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 2.21 | 0.77 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 1.11 | 3.77 | 2.58 | 0.00 | 0.74 | 1.15 | 0.00 | 0.81 | 0.78 | 0.00 | 3.55 | 2.17 | 0.69 | 0.00 | 0.83 | 2.88 | 0.00 | 0.00 |
| CHRNG | ENSG00000196811 | 0.00 | 0.51 | 0.31 | 1.09 | 0.00 | 0.97 | 0.00 | 1.66 | 0.26 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 1.51 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PTPRT | ENSG00000196090 | 0.00 | 4.33 | 0.52 | 2.55 | 0.00 | 5.48 | 2.70 | 5.52 | 2.58 | 3.78 | 0.00 | 1.90 | 1.07 | 0.74 | 0.00 | 2.78 | 8.10 | 5.79 | 0.00 | 2.21 | 1.72 | 0.00 | 0.20 | 6.25 | 0.86 | 21.33 | 7.32 | 0.00 | 0.20 | 0.00 | 5.54 | 1.82 | 0.00 |
| IFNGR2 | ENSG00000159128 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| DSCAM | ENSG00000171587 | 1.11 | 4.07 | 1.14 | 3.28 | 0.00 | 6.45 | 5.41 | 2.76 | 0.77 | 4.58 | 4.62 | 1.63 | 2.14 | 0.74 | 0.78 | 2.78 | 7.34 | 6.87 | 1.23 | 2.21 | 2.30 | 0.00 | 0.61 | 2.34 | 3.02 | 26.78 | 4.88 | 0.00 | 0.00 | 0.00 | 6.43 | 3.64 | 1.25 |
| SLC16A8 | ENSG00000100156 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SCN5A | ENSG00000183873 | 0.00 | 3.31 | 1.34 | 1.46 | 0.00 | 5.81 | 0.00 | 5.52 | 1.29 | 1.39 | 0.00 | 0.81 | 0.36 | 0.00 | 0.59 | 1.67 | 4.52 | 6.01 | 0.00 | 1.47 | 3.45 | 0.00 | 1.63 | 2.34 | 1.29 | 15.40 | 4.07 | 0.00 | 0.20 | 1.65 | 3.33 | 1.82 | 0.00 |
| TLR6 | ENSG00000174130 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 1.80 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 1.88 | 0.86 | 0.00 | 1.23 | 1.15 | 0.00 | 0.00 | 0.78 | 0.43 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| TMPRSS11B | ENSG00000185873 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 2.07 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 4.03 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| TMPRSS11E | ENSG00000087128 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.56 | 2.45 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 3.55 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| GYPB | ENSG00000250361 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLC6A3 | ENSG00000142319 | 0.00 | 1.02 | 0.41 | 1.09 | 0.00 | 0.65 | 0.00 | 2.76 | 1.29 | 1.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.98 | 0.56 | 1.13 | 4.08 | 0.00 | 1.47 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 3.32 | 0.27 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
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