Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| LAG3 | ENSG00000089692 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.83 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PTPRO | ENSG00000151490 | 0.00 | 2.04 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 1.59 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 1.11 | 2.45 | 5.79 | 0.00 | 1.23 | 0.57 | 0.00 | 0.61 | 0.78 | 1.29 | 4.27 | 1.63 | 1.39 | 0.20 | 0.00 | 2.88 | 0.00 | 0.00 |
| SLC38A2 | ENSG00000134294 | 0.00 | 2.54 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 1.47 | 0.00 | 0.56 | 0.38 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KL | ENSG00000133116 | 0.00 | 1.53 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 1.20 | 0.00 | 0.54 | 1.07 | 0.74 | 0.39 | 0.83 | 1.51 | 1.72 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 5.92 | 1.63 | 0.69 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| SLC39A2 | ENSG00000165794 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.41 | 0.00 | 0.22 | 0.00 | 0.00 |
| FLVCR2 | ENSG00000119686 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.00 | 0.19 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 1.82 | 0.00 |
| DLL4 | ENSG00000128917 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 1.07 | 0.00 | 0.00 | 1.15 | 0.00 | 0.20 | 0.78 | 0.43 | 3.32 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| DUOX1 | ENSG00000137857 | 0.00 | 0.51 | 0.72 | 0.36 | 0.00 | 1.29 | 5.41 | 0.00 | 0.26 | 1.39 | 0.00 | 1.08 | 0.36 | 0.00 | 0.00 | 1.11 | 0.94 | 1.07 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 2.34 | 0.86 | 1.66 | 2.44 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| NRG4 | ENSG00000169752 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CHRNB4 | ENSG00000117971 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.77 | 0.40 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.00 | 1.69 | 1.50 | 1.23 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 1.63 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| UMOD | ENSG00000169344 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 1.61 | 0.00 | 1.10 | 1.29 | 0.80 | 0.00 | 0.27 | 0.00 | 1.47 | 0.00 | 0.56 | 2.26 | 2.79 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 1.56 | 0.43 | 2.37 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 1.25 |
| ZP2 | ENSG00000103310 | 0.00 | 1.53 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.27 | 1.07 | 0.00 | 0.59 | 0.28 | 0.75 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 3.32 | 0.54 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ITGAD | ENSG00000156886 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 1.61 | 0.00 | 2.21 | 1.29 | 0.80 | 0.00 | 0.54 | 1.07 | 1.47 | 0.39 | 1.94 | 4.71 | 3.65 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 5.45 | 1.36 | 0.00 | 0.20 | 0.00 | 2.66 | 0.00 | 0.00 |
| TRPV3 | ENSG00000167723 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.00 | 0.71 | 1.47 | 0.20 | 0.56 | 1.51 | 1.07 | 0.00 | 1.47 | 0.57 | 0.00 | 0.00 | 1.56 | 0.86 | 1.18 | 0.54 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| RAMP2 | ENSG00000131477 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CD300LG | ENSG00000161649 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC16A6 | ENSG00000108932 | 0.00 | 1.27 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.83 | 0.56 | 0.43 | 1.23 | 0.00 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CD300A | ENSG00000167851 | 1.11 | 0.25 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| CD300C | ENSG00000167850 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.56 | 0.75 | 1.07 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CD300LF | ENSG00000186074 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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