Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CRHR2 | ENSG00000106113 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.80 | 1.54 | 0.27 | 0.36 | 0.00 | 0.39 | 0.28 | 0.19 | 0.86 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 1.56 | 0.86 | 2.37 | 0.54 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| GRM3 | ENSG00000198822 | 3.33 | 1.27 | 1.14 | 0.36 | 2.86 | 1.61 | 0.00 | 3.87 | 2.58 | 4.58 | 3.08 | 0.54 | 0.71 | 0.74 | 0.78 | 1.11 | 2.07 | 5.36 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 2.34 | 0.43 | 10.43 | 2.98 | 0.00 | 0.00 | 0.00 | 2.88 | 1.82 | 0.00 |
| GPR85 | ENSG00000164604 | 1.11 | 0.76 | 0.21 | 0.73 | 2.86 | 0.65 | 0.00 | 1.10 | 0.52 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 2.07 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TAS2R16 | ENSG00000128519 | 0.00 | 0.76 | 0.52 | 0.36 | 0.00 | 0.00 | 5.41 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 1.88 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GPR37 | ENSG00000170775 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.99 | 0.00 | 0.00 | 1.07 | 0.00 | 0.39 | 0.56 | 2.45 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 2.34 | 0.86 | 0.71 | 1.63 | 0.69 | 0.00 | 0.00 | 0.44 | 3.64 | 0.00 |
| TAS2R4 | ENSG00000127364 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.21 | 1.23 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TRPA1 | ENSG00000104321 | 2.22 | 3.82 | 0.93 | 1.46 | 0.00 | 3.23 | 0.00 | 2.21 | 1.80 | 2.59 | 0.00 | 0.00 | 0.36 | 0.00 | 1.37 | 3.61 | 7.53 | 7.30 | 1.23 | 1.47 | 0.57 | 0.00 | 0.81 | 0.78 | 0.86 | 1.66 | 5.69 | 0.00 | 0.20 | 0.00 | 2.66 | 0.00 | 0.00 |
| EPHA10 | ENSG00000183317 | 2.22 | 0.76 | 0.21 | 1.09 | 0.00 | 1.94 | 0.00 | 1.66 | 1.80 | 1.59 | 0.00 | 0.27 | 0.00 | 0.74 | 0.59 | 0.56 | 2.07 | 2.79 | 0.00 | 1.47 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 3.79 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| FCRL4 | ENSG00000163518 | 0.00 | 1.27 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.77 | 2.79 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 2.26 | 4.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 3.55 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| CD1E | ENSG00000158488 | 1.11 | 2.80 | 0.83 | 0.73 | 0.00 | 1.94 | 0.00 | 3.31 | 0.26 | 2.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.83 | 3.77 | 2.79 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 3.13 | 0.86 | 5.92 | 2.71 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| FASLG | ENSG00000117560 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 1.13 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| USH2A | ENSG00000042781 | 2.22 | 7.89 | 5.37 | 8.76 | 0.00 | 9.35 | 13.51 | 9.39 | 5.15 | 11.55 | 0.00 | 3.52 | 4.98 | 1.47 | 1.37 | 6.39 | 26.55 | 32.19 | 3.70 | 7.11 | 3.45 | 0.00 | 2.85 | 7.81 | 4.31 | 25.12 | 10.57 | 0.69 | 0.41 | 0.83 | 9.98 | 3.64 | 0.00 |
| LRRTM3 | ENSG00000198739 | 0.00 | 1.27 | 0.31 | 1.09 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 2.99 | 0.00 | 1.08 | 0.00 | 0.00 | 0.20 | 0.83 | 3.01 | 3.43 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 2.37 | 1.63 | 1.39 | 0.00 | 0.00 | 1.33 | 0.00 | 1.25 |
| BMPR1A | ENSG00000107779 | 0.00 | 0.51 | 0.00 | 1.09 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 1.07 | 0.74 | 0.00 | 0.28 | 0.38 | 1.07 | 0.00 | 0.49 | 1.15 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR51B5 | ENSG00000242180 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 1.13 | 2.15 | 1.23 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 4.03 | 1.63 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC6A5 | ENSG00000165970 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 2.21 | 0.77 | 1.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 4.14 | 2.79 | 0.00 | 0.49 | 0.57 | 0.00 | 0.81 | 1.56 | 0.43 | 3.79 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| MUC15 | ENSG00000169550 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.00 | 5.41 | 2.76 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.28 | 1.13 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ZP1 | ENSG00000149506 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.51 | 0.43 | 0.00 | 0.98 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| KCNK4 | ENSG00000182450 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLCO2B1 | ENSG00000137491 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.80 | 0.00 | 0.54 | 1.42 | 0.74 | 0.20 | 0.56 | 2.07 | 1.72 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.81 | 0.00 | 0.61 | 0.00 | 1.55 | 0.00 | 1.25 |
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