Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GRIN2A | ENSG00000183454 | 0.00 | 3.31 | 1.86 | 2.19 | 0.00 | 4.84 | 5.41 | 0.55 | 3.35 | 3.78 | 1.54 | 1.36 | 1.42 | 0.00 | 1.18 | 1.11 | 8.10 | 7.73 | 0.00 | 1.96 | 0.00 | 0.00 | 1.63 | 3.91 | 0.43 | 18.48 | 2.71 | 0.00 | 0.41 | 0.83 | 3.33 | 1.82 | 1.25 |
| GPRC5B | ENSG00000167191 | 0.00 | 0.25 | 0.31 | 1.46 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 1.69 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 1.08 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR4D2 | ENSG00000255713 | 0.00 | 0.51 | 0.52 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.94 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| ADGRL1 | ENSG00000072071 | 1.11 | 2.04 | 0.41 | 1.46 | 2.86 | 1.29 | 2.70 | 0.55 | 0.52 | 1.99 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 0.94 | 1.29 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 1.56 | 0.86 | 2.37 | 0.54 | 0.69 | 0.00 | 0.00 | 2.88 | 1.82 | 0.00 |
| LPAR2 | ENSG00000064547 | 1.11 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.56 | 1.07 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| FPR2 | ENSG00000171049 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 1.66 | 1.29 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 1.51 | 1.93 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 3.32 | 1.63 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| KIR2DL4 | ENSG00000189013 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| LCT | ENSG00000115850 | 1.11 | 2.54 | 1.55 | 2.19 | 0.00 | 2.26 | 0.00 | 1.66 | 1.55 | 2.99 | 0.00 | 0.27 | 0.36 | 0.00 | 0.98 | 1.11 | 6.97 | 9.01 | 0.00 | 1.96 | 1.72 | 1.12 | 0.81 | 0.00 | 1.72 | 9.24 | 2.98 | 0.69 | 0.20 | 0.00 | 5.32 | 0.00 | 0.00 |
| KCNE1 | ENSG00000180509 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| UMODL1 | ENSG00000177398 | 1.11 | 2.04 | 0.52 | 1.82 | 0.00 | 0.32 | 0.00 | 1.10 | 1.80 | 0.60 | 0.00 | 1.08 | 1.42 | 0.00 | 0.39 | 1.67 | 2.45 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 2.34 | 0.86 | 4.50 | 1.90 | 0.69 | 0.00 | 0.83 | 2.88 | 0.00 | 1.25 |
| TRPM2 | ENSG00000142185 | 0.00 | 2.04 | 0.72 | 1.09 | 0.00 | 2.58 | 8.11 | 0.00 | 1.80 | 1.20 | 0.00 | 0.81 | 0.71 | 0.00 | 0.59 | 1.11 | 3.58 | 3.22 | 1.23 | 1.72 | 1.15 | 0.00 | 0.20 | 0.78 | 0.86 | 6.64 | 0.54 | 0.00 | 0.20 | 0.00 | 2.22 | 3.64 | 0.00 |
| CX3CR1 | ENSG00000168329 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| GRM2 | ENSG00000164082 | 0.00 | 2.54 | 0.31 | 0.00 | 0.00 | 1.94 | 2.70 | 0.55 | 0.00 | 1.20 | 0.00 | 0.54 | 0.36 | 0.74 | 0.20 | 1.11 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.37 | 3.79 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| HTR1F | ENSG00000179097 | 0.00 | 1.27 | 0.21 | 0.73 | 2.86 | 0.00 | 0.00 | 2.21 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 2.07 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 1.90 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| ACPP | ENSG00000014257 | 1.11 | 1.53 | 0.83 | 1.09 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 1.39 | 0.94 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GPR87 | ENSG00000138271 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.00 | 1.54 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.94 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 1.66 | 0.54 | 0.69 | 0.20 | 0.00 | 0.67 | 0.00 | 1.25 |
| GABRA1 | ENSG00000022355 | 1.11 | 2.29 | 0.31 | 0.73 | 0.00 | 1.29 | 5.41 | 3.31 | 1.55 | 1.99 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 1.94 | 3.01 | 1.93 | 1.23 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.55 | 2.44 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HTR1E | ENSG00000168830 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 1.66 | 1.03 | 1.39 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.56 | 2.82 | 3.22 | 0.00 | 0.00 | 0.00 | 0.00 | 1.22 | 1.56 | 0.00 | 2.61 | 1.36 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| GPR6 | ENSG00000146360 | 1.11 | 1.53 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 1.32 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 2.34 | 0.00 | 0.95 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GPRC6A | ENSG00000173612 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 1.80 | 2.39 | 0.00 | 0.00 | 0.71 | 0.74 | 0.78 | 1.67 | 4.14 | 2.79 | 0.00 | 1.23 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 9.95 | 1.63 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
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