Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR13J1 | ENSG00000168828 | 0.00 | 0.51 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR13C9 | ENSG00000136839 | 0.00 | 1.27 | 0.31 | 1.09 | 0.00 | 1.29 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR2K2 | ENSG00000171133 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR1K1 | ENSG00000165204 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.83 | 0.94 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GPR82 | ENSG00000171657 | 2.22 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC16A4 | ENSG00000168679 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 1.66 | 0.00 | 0.40 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| GPR161 | ENSG00000143147 | 0.00 | 1.53 | 0.52 | 0.00 | 0.00 | 0.65 | 0.00 | 2.21 | 0.52 | 0.20 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.56 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 1.56 | 0.43 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| FZD8 | ENSG00000177283 | 1.11 | 0.76 | 0.10 | 0.73 | 2.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.28 | 0.75 | 1.07 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.69 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
| NPY4R | ENSG00000204174 | 0.00 | 1.27 | 0.31 | 0.36 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.00 | 0.94 | 1.50 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.86 | 2.37 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| NRG3 | ENSG00000185737 | 2.22 | 1.78 | 0.52 | 0.36 | 0.00 | 1.61 | 0.00 | 2.76 | 0.00 | 2.99 | 0.00 | 0.54 | 1.07 | 0.00 | 0.00 | 1.11 | 4.14 | 5.15 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 4.74 | 3.25 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR51E1 | ENSG00000180785 | 1.11 | 0.76 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 0.56 | 0.38 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 3.08 | 0.81 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR10A2 | ENSG00000170790 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 2.82 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| MRGPRX2 | ENSG00000183695 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 2.37 | 2.17 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR4A15 | ENSG00000181958 | 0.00 | 1.78 | 0.52 | 0.36 | 0.00 | 2.26 | 0.00 | 2.21 | 0.77 | 1.79 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 0.83 | 6.78 | 6.01 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 1.56 | 0.43 | 7.82 | 2.71 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| MRGPRD | ENSG00000172938 | 0.00 | 0.51 | 0.21 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 0.00 | 0.75 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TAS2R46 | ENSG00000226761 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GPRC5D | ENSG00000111291 | 1.11 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.00 | 0.38 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| FZD10 | ENSG00000111432 | 0.00 | 1.53 | 0.10 | 0.73 | 0.00 | 1.61 | 2.70 | 0.00 | 0.77 | 0.60 | 0.00 | 1.08 | 0.36 | 0.00 | 0.39 | 0.83 | 3.77 | 0.64 | 0.00 | 0.00 | 1.15 | 0.00 | 0.41 | 0.78 | 0.00 | 0.71 | 1.63 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| GPR12 | ENSG00000132975 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 1.66 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| GPR18 | ENSG00000125245 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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