Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GPR4 | ENSG00000177464 | 1.11 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.54 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 1.25 |
| GPR32 | ENSG00000142511 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 1.66 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 1.88 | 1.07 | 1.23 | 0.49 | 0.00 | 0.00 | 0.41 | 3.13 | 0.43 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| FPR3 | ENSG00000187474 | 0.00 | 0.76 | 0.52 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| VN1R4 | ENSG00000228567 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 2.45 | 2.36 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 3.08 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| NTSR2 | ENSG00000169006 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.38 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| SCTR | ENSG00000080293 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 2.37 | 0.81 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| GPR17 | ENSG00000144230 | 0.00 | 0.76 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 0.94 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PTH2R | ENSG00000144407 | 0.00 | 1.27 | 0.31 | 0.73 | 0.00 | 1.94 | 0.00 | 1.10 | 0.52 | 1.59 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 1.88 | 2.36 | 1.23 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.86 | 3.79 | 0.81 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| HRH3 | ENSG00000101180 | 0.00 | 0.76 | 0.31 | 0.00 | 2.86 | 0.65 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.56 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| NPBWR2 | ENSG00000125522 | 1.11 | 1.02 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 2.21 | 0.77 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 0.94 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.37 | 1.08 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR11H1 | ENSG00000130538 | 1.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 1.66 | 0.26 | 1.59 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 3.77 | 2.36 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 4.03 | 0.81 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| ACKR2 | ENSG00000144648 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR5AC2 | ENSG00000196578 | 0.00 | 2.04 | 0.21 | 0.73 | 0.00 | 1.61 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.94 | 2.15 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 4.03 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR5H14 | ENSG00000236032 | 1.11 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 1.79 | 0.00 | 0.00 | 0.36 | 0.00 | 0.98 | 1.94 | 1.32 | 3.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 4.50 | 1.90 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR5H6 | ENSG00000230301 | 0.00 | 1.53 | 0.31 | 1.09 | 0.00 | 1.61 | 0.00 | 0.55 | 0.52 | 1.39 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 1.51 | 2.79 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.78 | 0.43 | 5.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR5H2 | ENSG00000197938 | 1.11 | 0.51 | 0.41 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.59 | 0.28 | 1.13 | 2.36 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.32 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR5K4 | ENSG00000196098 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 1.29 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 1.13 | 2.79 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GPR78 | ENSG00000155269 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 1.25 |
| GNRHR | ENSG00000109163 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 0.75 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| TACR3 | ENSG00000169836 | 1.11 | 1.02 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 1.29 | 1.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.59 | 1.67 | 2.45 | 1.72 | 0.00 | 0.98 | 0.57 | 0.00 | 0.41 | 3.91 | 0.00 | 5.92 | 1.63 | 0.00 | 0.41 | 0.00 | 1.77 | 0.00 | 0.00 |
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