Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR1A2 | ENSG00000172150 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR1A1 | ENSG00000172146 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 1.88 | 0.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR3A1 | ENSG00000180090 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.65 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 1.51 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR4D1 | ENSG00000141194 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SSTR2 | ENSG00000180616 | 1.11 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| UTS2R | ENSG00000181408 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MC5R | ENSG00000176136 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 1.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.28 | 2.45 | 1.50 | 0.00 | 1.23 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| MC2R | ENSG00000185231 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.69 | 2.36 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 2.50 |
| HRH4 | ENSG00000134489 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 0.75 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR4F17 | ENSG00000176695 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR1M1 | ENSG00000170929 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.65 | 2.70 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 0.56 | 1.69 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR7G1 | ENSG00000161807 | 0.00 | 0.00 | 0.10 | 1.09 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 1.69 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR7D4 | ENSG00000174667 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.51 | 2.36 | 0.00 | 0.74 | 1.15 | 0.00 | 0.20 | 0.00 | 0.86 | 3.79 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| PTGER1 | ENSG00000160951 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR7A17 | ENSG00000185385 | 0.00 | 0.25 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.39 | 0.28 | 0.94 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR10H2 | ENSG00000171942 | 0.00 | 0.25 | 0.41 | 1.09 | 0.00 | 1.29 | 0.00 | 1.10 | 0.26 | 0.40 | 1.54 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 1.13 | 2.36 | 0.00 | 0.74 | 0.57 | 0.56 | 0.20 | 0.78 | 0.00 | 2.37 | 0.00 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR10H5 | ENSG00000172519 | 1.11 | 0.25 | 0.21 | 0.36 | 0.00 | 1.94 | 2.70 | 1.10 | 0.52 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.00 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| OR10H1 | ENSG00000186723 | 1.11 | 0.51 | 0.31 | 0.00 | 2.86 | 0.65 | 0.00 | 1.10 | 1.03 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 1.39 | 0.56 | 1.29 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 3.32 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR10H4 | ENSG00000176231 | 0.00 | 0.76 | 0.21 | 0.00 | 2.86 | 0.00 | 0.00 | 1.10 | 0.52 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 0.94 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.37 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| FFAR3 | ENSG00000185897 | 1.11 | 1.27 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 1.03 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.94 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 2.44 | 1.82 | 0.00 |
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