Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR14C36 | ENSG00000177174 | 1.11 | 0.76 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 3.58 | 3.65 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.13 | 1.36 | 0.00 | 0.20 | 0.00 | 2.22 | 0.00 | 0.00 |
| OR2T6 | ENSG00000198104 | 0.00 | 1.27 | 0.21 | 1.09 | 0.00 | 1.61 | 0.00 | 1.10 | 1.03 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 1.39 | 4.33 | 3.00 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 2.61 | 2.17 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR2T3 | ENSG00000196539 | 0.00 | 1.02 | 0.52 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 1.39 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.56 | 4.71 | 5.15 | 0.00 | 0.49 | 0.57 | 0.00 | 0.61 | 0.78 | 0.00 | 2.13 | 1.90 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR2T34 | ENSG00000183310 | 0.00 | 0.76 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 3.01 | 4.51 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.37 | 1.08 | 0.69 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR2T10 | ENSG00000184022 | 1.11 | 1.02 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.56 | 2.45 | 4.08 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PKD2L1 | ENSG00000107593 | 0.00 | 1.53 | 0.41 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.59 | 0.00 | 0.81 | 0.00 | 0.74 | 0.00 | 0.00 | 1.32 | 2.36 | 0.00 | 1.96 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| MRGPRE | ENSG00000184350 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR51G2 | ENSG00000176893 | 0.00 | 1.78 | 0.21 | 0.00 | 2.86 | 0.00 | 0.00 | 1.66 | 0.00 | 1.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 3.58 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.79 | 1.63 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR51V1 | ENSG00000176742 | 0.00 | 0.51 | 0.52 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 4.14 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 3.08 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR51I2 | ENSG00000187918 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 5.41 | 0.55 | 0.26 | 1.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 1.51 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 1.56 | 0.86 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR52H1 | ENSG00000181616 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 1.10 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 1.36 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR56B1 | ENSG00000181023 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 1.66 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 1.13 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.61 | 1.90 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR52B2 | ENSG00000255307 | 0.00 | 0.76 | 0.52 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 1.03 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.51 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR10A4 | ENSG00000170782 | 1.11 | 0.51 | 0.10 | 0.36 | 0.00 | 0.97 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 1.51 | 2.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 2.44 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR2D2 | ENSG00000166368 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 2.07 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.66 | 1.08 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| OR4B1 | ENSG00000175619 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 1.32 | 3.22 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR4S1 | ENSG00000176555 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.65 | 2.70 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 1.13 | 1.72 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 1.56 | 1.29 | 1.66 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR4C12 | ENSG00000221954 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 1.66 | 0.77 | 1.59 | 1.54 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 2.07 | 6.87 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 2.84 | 1.90 | 0.00 | 0.00 | 0.00 | 1.11 | 3.64 | 0.00 |
| OR4A5 | ENSG00000221840 | 0.00 | 0.76 | 0.52 | 0.73 | 0.00 | 1.61 | 0.00 | 1.66 | 0.26 | 1.59 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 3.95 | 2.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 3.13 | 0.86 | 4.74 | 2.44 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR4A16 | ENSG00000181961 | 1.11 | 2.04 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 2.21 | 0.26 | 1.59 | 0.00 | 0.27 | 1.07 | 0.00 | 0.78 | 0.28 | 5.08 | 4.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 3.55 | 2.44 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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