Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR4F5 | ENSG00000186092 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ADGRB2 | ENSG00000121753 | 1.11 | 1.27 | 0.41 | 2.19 | 0.00 | 2.58 | 0.00 | 2.76 | 0.52 | 1.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 1.39 | 2.26 | 3.43 | 0.00 | 1.47 | 1.15 | 0.00 | 0.20 | 1.56 | 0.00 | 1.42 | 0.27 | 0.00 | 0.20 | 0.00 | 4.43 | 0.00 | 0.00 |
| OR10T2 | ENSG00000186306 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 1.69 | 2.15 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 3.08 | 1.36 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR10K2 | ENSG00000180708 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 1.39 | 3.01 | 3.65 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.78 | 0.43 | 4.50 | 2.71 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR10K1 | ENSG00000173285 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 0.97 | 0.00 | 1.10 | 0.00 | 0.60 | 1.54 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 2.07 | 2.79 | 1.23 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 3.79 | 2.44 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| OR10R2 | ENSG00000198965 | 0.00 | 1.53 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 2.21 | 0.77 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.83 | 3.01 | 2.36 | 0.00 | 0.49 | 0.57 | 0.00 | 0.81 | 0.78 | 0.00 | 2.13 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR10Z1 | ENSG00000198967 | 0.00 | 2.04 | 0.72 | 0.00 | 0.00 | 0.32 | 0.00 | 3.31 | 0.52 | 0.60 | 1.54 | 0.00 | 0.00 | 0.00 | 0.20 | 1.11 | 3.39 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.61 | 0.78 | 0.86 | 3.55 | 1.08 | 0.00 | 0.20 | 0.83 | 0.67 | 1.82 | 0.00 |
| OR6N1 | ENSG00000197403 | 0.00 | 2.54 | 0.41 | 1.09 | 0.00 | 0.65 | 2.70 | 1.66 | 0.52 | 1.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 2.82 | 2.58 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 3.79 | 2.17 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR10J3 | ENSG00000196266 | 0.00 | 1.78 | 0.52 | 0.36 | 2.86 | 0.65 | 0.00 | 1.10 | 0.52 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.28 | 3.39 | 1.93 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 4.50 | 2.98 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| OR10J1 | ENSG00000196184 | 1.11 | 0.76 | 0.52 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 1.88 | 1.07 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 0.78 | 0.00 | 4.27 | 2.17 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR10J5 | ENSG00000184155 | 0.00 | 1.27 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 2.21 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.56 | 1.13 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GPR52 | ENSG00000203737 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.65 | 2.70 | 2.21 | 0.77 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.69 | 0.00 | 0.83 | 0.89 | 1.82 | 0.00 |
| OR2B11 | ENSG00000177535 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.39 | 3.39 | 3.22 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR13G1 | ENSG00000197437 | 0.00 | 1.02 | 0.83 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 1.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.56 | 3.01 | 2.36 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 2.84 | 1.63 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR1C1 | ENSG00000221888 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 2.58 | 0.00 | 1.10 | 0.26 | 1.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.83 | 3.20 | 5.15 | 0.00 | 0.00 | 1.15 | 0.00 | 0.00 | 0.78 | 0.86 | 2.61 | 1.36 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| OR2L13 | ENSG00000196071 | 0.00 | 0.25 | 0.41 | 0.00 | 2.86 | 0.97 | 0.00 | 0.55 | 0.77 | 1.39 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.83 | 4.71 | 5.79 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 1.56 | 0.43 | 4.03 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR2L2 | ENSG00000203663 | 0.00 | 0.51 | 0.62 | 0.00 | 0.00 | 0.97 | 5.41 | 2.21 | 0.52 | 1.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 5.27 | 4.94 | 0.00 | 0.25 | 1.15 | 0.56 | 0.00 | 0.00 | 0.00 | 3.08 | 1.36 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 1.25 |
| OR2L3 | ENSG00000198128 | 0.00 | 1.78 | 0.52 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.83 | 3.58 | 3.22 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 4.50 | 1.63 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR2M4 | ENSG00000171180 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 1.94 | 0.00 | 1.66 | 1.29 | 1.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 4.14 | 3.86 | 0.00 | 0.25 | 1.15 | 0.00 | 0.20 | 1.56 | 0.43 | 2.84 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR2T33 | ENSG00000177212 | 1.11 | 1.53 | 0.52 | 0.73 | 0.00 | 1.29 | 0.00 | 3.87 | 1.55 | 1.79 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 0.28 | 5.08 | 4.29 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.79 | 1.08 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
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