Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| BGN | ENSG00000182492 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| ADORA2A | ENSG00000128271 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 1.07 | 0.74 | 0.00 | 0.56 | 0.38 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CALCR | ENSG00000004948 | 0.00 | 1.53 | 0.31 | 0.73 | 2.86 | 1.29 | 2.70 | 0.00 | 2.58 | 0.80 | 0.00 | 0.00 | 1.07 | 0.74 | 0.20 | 0.28 | 3.20 | 5.15 | 0.00 | 1.47 | 0.00 | 0.00 | 0.61 | 0.78 | 0.86 | 4.50 | 0.81 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| OPRD1 | ENSG00000116329 | 0.00 | 1.02 | 0.21 | 0.36 | 2.86 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 1.54 | 1.08 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 1.65 | 0.67 | 0.00 | 0.00 |
| HCRTR1 | ENSG00000121764 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CHRM1 | ENSG00000168539 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 0.75 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.83 | 1.33 | 0.00 | 1.25 |
| CRHR1 | ENSG00000120088 | 0.00 | 0.25 | 0.31 | 1.46 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.54 | 0.00 | 1.47 | 0.00 | 1.39 | 0.75 | 1.29 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.20 | 0.83 | 0.44 | 0.00 | 0.00 |
| FFAR1 | ENSG00000126266 | 1.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CCR9 | ENSG00000173585 | 0.00 | 0.00 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 1.66 | 0.77 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.28 | 0.00 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 1.08 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| DRD3 | ENSG00000151577 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 1.00 | 1.54 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 1.88 | 3.65 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| RHO | ENSG00000163914 | 0.00 | 0.51 | 0.41 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 1.63 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| P2RY12 | ENSG00000169313 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HCRTR2 | ENSG00000137252 | 0.00 | 1.78 | 0.41 | 0.73 | 0.00 | 0.65 | 2.70 | 1.66 | 0.52 | 1.20 | 0.00 | 0.27 | 1.78 | 0.00 | 0.20 | 0.56 | 2.82 | 1.07 | 1.23 | 0.49 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 5.92 | 1.08 | 0.00 | 0.00 | 0.83 | 1.11 | 3.64 | 0.00 |
| P2RY2 | ENSG00000175591 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| GRM5 | ENSG00000168959 | 1.11 | 4.33 | 0.41 | 2.19 | 2.86 | 1.94 | 0.00 | 1.66 | 0.52 | 1.79 | 0.00 | 1.08 | 0.71 | 0.00 | 0.39 | 1.11 | 6.78 | 6.01 | 1.23 | 0.74 | 0.00 | 0.00 | 0.41 | 3.13 | 0.86 | 3.32 | 5.15 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| CHRNA7 | ENSG00000175344 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.39 | 1.32 | 0.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 1.65 | 1.11 | 0.00 | 0.00 |
| P2RY14 | ENSG00000174944 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| NPY5R | ENSG00000164129 | 0.00 | 1.27 | 0.00 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 1.29 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.67 | 2.64 | 2.15 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 2.34 | 0.00 | 4.98 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| MTNR1A | ENSG00000168412 | 0.00 | 1.27 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 1.88 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| DRD1 | ENSG00000184845 | 0.00 | 0.25 | 0.00 | 0.00 | 2.86 | 0.00 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.25 | 1.15 | 0.00 | 0.00 | 0.00 | 0.43 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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