Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC45A2 | ENSG00000164175 | 1.11 | 0.51 | 0.52 | 0.73 | 0.00 | 1.29 | 2.70 | 0.55 | 0.00 | 1.20 | 0.00 | 0.54 | 1.42 | 0.00 | 0.00 | 0.56 | 3.01 | 3.00 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.83 | 1.55 | 0.00 | 0.00 |
| GPC4 | ENSG00000076716 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 1.29 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.74 | 0.39 | 0.28 | 1.69 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.43 | 3.55 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| DBH | ENSG00000123454 | 1.11 | 0.25 | 0.62 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 1.55 | 1.59 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.28 | 1.69 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 1.02 | 0.78 | 0.00 | 3.08 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| NTNG1 | ENSG00000162631 | 1.11 | 1.53 | 0.21 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 4.52 | 2.58 | 0.00 | 1.23 | 1.15 | 0.00 | 0.41 | 1.56 | 0.00 | 2.61 | 3.25 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SMPD1 | ENSG00000166311 | 0.00 | 1.53 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.20 | 1.54 | 0.27 | 0.71 | 0.00 | 0.20 | 0.00 | 0.38 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.69 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| NEU1 | ENSG00000204386 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.38 | 0.86 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PON2 | ENSG00000105854 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SMPDL3B | ENSG00000130768 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| F2 | ENSG00000180210 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 1.03 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.56 | 0.75 | 0.64 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.84 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| IFI30 | ENSG00000216490 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ELANE | ENSG00000197561 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CNTN2 | ENSG00000184144 | 0.00 | 1.78 | 0.62 | 0.73 | 2.86 | 0.65 | 0.00 | 0.55 | 0.77 | 1.79 | 0.00 | 0.27 | 0.36 | 0.74 | 0.39 | 1.94 | 2.82 | 1.50 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 3.79 | 0.54 | 0.00 | 0.00 | 0.83 | 1.77 | 1.82 | 1.25 |
| TGFB1 | ENSG00000105329 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| F5 | ENSG00000198734 | 2.22 | 4.07 | 2.27 | 1.46 | 0.00 | 1.29 | 0.00 | 1.66 | 2.32 | 2.99 | 0.00 | 0.27 | 1.07 | 0.00 | 0.98 | 1.67 | 5.84 | 7.51 | 1.23 | 2.70 | 1.15 | 0.00 | 0.81 | 1.56 | 1.29 | 8.29 | 2.98 | 0.00 | 0.00 | 0.00 | 3.55 | 0.00 | 1.25 |
| C4BPA | ENSG00000123838 | 0.00 | 1.02 | 0.83 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.98 | 0.28 | 1.13 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 2.34 | 0.43 | 2.61 | 1.36 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| SCUBE1 | ENSG00000159307 | 0.00 | 1.78 | 0.21 | 0.36 | 0.00 | 1.61 | 2.70 | 2.21 | 0.77 | 0.80 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 0.94 | 2.36 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 1.72 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 2.66 | 1.82 | 0.00 |
| C4BPB | ENSG00000123843 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.00 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| APOH | ENSG00000091583 | 0.00 | 0.51 | 0.21 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.56 | 0.75 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KNG1 | ENSG00000113889 | 1.11 | 0.76 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.81 | 1.07 | 0.00 | 0.00 | 0.83 | 0.75 | 3.22 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.55 | 1.36 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PDGFC | ENSG00000145431 | 0.00 | 1.27 | 0.10 | 1.09 | 0.00 | 0.32 | 5.41 | 0.55 | 0.77 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.83 | 0.38 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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