Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TMX4 | ENSG00000125827 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.75 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| SLC12A5 | ENSG00000124140 | 0.00 | 2.04 | 1.14 | 1.82 | 0.00 | 1.29 | 0.00 | 1.10 | 1.80 | 1.79 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 1.39 | 4.14 | 3.43 | 1.23 | 1.47 | 1.15 | 0.00 | 0.81 | 0.78 | 0.43 | 6.40 | 2.98 | 0.00 | 0.20 | 0.00 | 1.77 | 1.82 | 1.25 |
| KCNG1 | ENSG00000026559 | 0.00 | 0.76 | 0.21 | 0.36 | 2.86 | 2.26 | 0.00 | 1.10 | 0.77 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 1.51 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 2.34 | 0.00 | 1.90 | 2.44 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| TDGF1 | ENSG00000241186 | 0.00 | 1.27 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC10A6 | ENSG00000145283 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.75 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| NOTCH4 | ENSG00000204301 | 2.22 | 3.31 | 0.83 | 2.19 | 0.00 | 0.97 | 0.00 | 1.66 | 1.03 | 1.39 | 0.00 | 0.27 | 0.36 | 1.47 | 0.59 | 2.22 | 6.78 | 3.65 | 0.00 | 3.19 | 0.57 | 0.56 | 0.20 | 1.56 | 1.72 | 10.90 | 2.71 | 0.00 | 0.41 | 0.83 | 3.55 | 1.82 | 0.00 |
| PKHD1 | ENSG00000170927 | 7.78 | 7.12 | 1.76 | 4.01 | 5.71 | 5.48 | 0.00 | 2.21 | 6.19 | 5.58 | 0.00 | 2.71 | 5.34 | 0.74 | 2.35 | 4.44 | 11.30 | 17.60 | 2.47 | 4.41 | 1.72 | 0.00 | 1.22 | 7.03 | 3.45 | 9.95 | 6.78 | 1.39 | 0.81 | 0.00 | 7.10 | 1.82 | 0.00 |
| ADCY1 | ENSG00000164742 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 1.94 | 0.00 | 1.66 | 1.80 | 3.19 | 0.00 | 0.54 | 0.36 | 0.74 | 0.20 | 0.83 | 3.01 | 4.08 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 3.91 | 0.43 | 5.92 | 0.81 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| KCND2 | ENSG00000184408 | 1.11 | 1.78 | 0.72 | 0.73 | 0.00 | 1.94 | 2.70 | 1.66 | 0.00 | 1.99 | 0.00 | 1.08 | 0.36 | 0.74 | 0.20 | 0.83 | 3.39 | 4.29 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 2.34 | 0.43 | 7.11 | 3.25 | 0.69 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| ATP6V0A4 | ENSG00000105929 | 1.11 | 1.02 | 0.21 | 1.09 | 0.00 | 0.97 | 2.70 | 0.00 | 1.29 | 1.20 | 1.54 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.94 | 1.72 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 2.34 | 0.86 | 4.03 | 2.17 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| TYRP1 | ENSG00000107165 | 1.11 | 0.51 | 0.72 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.80 | 3.08 | 0.27 | 0.71 | 0.00 | 0.59 | 0.00 | 0.56 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 1.90 | 0.00 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 2.50 |
| SLC24A2 | ENSG00000155886 | 1.11 | 1.27 | 0.21 | 1.09 | 0.00 | 1.61 | 0.00 | 1.10 | 0.26 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 1.39 | 2.82 | 1.93 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 1.63 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| NOX1 | ENSG00000007952 | 0.00 | 0.51 | 0.41 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 1.11 | 1.13 | 1.07 | 1.23 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC15A3 | ENSG00000110446 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| KCNK7 | ENSG00000173338 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 1.08 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KCNH5 | ENSG00000140015 | 0.00 | 1.78 | 0.31 | 0.73 | 0.00 | 3.23 | 2.70 | 0.55 | 1.29 | 1.59 | 0.00 | 1.08 | 0.71 | 0.00 | 0.20 | 1.39 | 5.08 | 3.22 | 0.00 | 1.47 | 1.15 | 1.69 | 0.61 | 3.13 | 0.86 | 13.03 | 3.25 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 2.50 |
| KCNK13 | ENSG00000152315 | 0.00 | 0.76 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.77 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.69 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 3.32 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| KCNH6 | ENSG00000173826 | 1.11 | 2.54 | 0.72 | 1.09 | 0.00 | 0.00 | 2.70 | 1.10 | 1.55 | 1.00 | 0.00 | 0.81 | 0.71 | 0.00 | 0.20 | 1.39 | 2.45 | 2.79 | 0.00 | 0.25 | 0.57 | 0.56 | 0.00 | 0.78 | 0.86 | 5.92 | 1.63 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| KCNJ15 | ENSG00000157551 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 0.60 | 0.00 | 0.54 | 1.07 | 0.00 | 0.59 | 0.28 | 0.56 | 1.07 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MFSD8 | ENSG00000164073 | 0.00 | 1.27 | 0.31 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 0.43 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
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