Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TYR | ENSG00000077498 | 0.00 | 1.53 | 0.72 | 0.73 | 0.00 | 0.65 | 2.70 | 1.66 | 1.55 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 1.11 | 3.77 | 3.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 1.56 | 0.86 | 1.90 | 2.17 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| FAT3 | ENSG00000165323 | 4.44 | 9.92 | 3.31 | 3.28 | 0.00 | 10.32 | 2.70 | 9.94 | 1.03 | 7.97 | 1.54 | 2.44 | 1.07 | 0.00 | 1.18 | 6.94 | 17.70 | 15.67 | 0.00 | 5.64 | 2.87 | 0.00 | 3.26 | 10.94 | 3.02 | 24.88 | 11.92 | 1.39 | 0.61 | 0.00 | 9.53 | 3.64 | 1.25 |
| KCNA1 | ENSG00000111262 | 0.00 | 1.78 | 0.83 | 1.09 | 0.00 | 2.26 | 0.00 | 2.21 | 0.26 | 1.00 | 0.00 | 0.54 | 0.00 | 1.47 | 0.20 | 1.39 | 2.45 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.00 | 1.29 | 3.55 | 2.17 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| THSD1 | ENSG00000136114 | 1.11 | 1.53 | 0.31 | 2.19 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.83 | 1.69 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 2.13 | 2.17 | 0.69 | 0.41 | 0.00 | 2.88 | 0.00 | 1.25 |
| DCT | ENSG00000080166 | 0.00 | 2.54 | 0.41 | 0.36 | 2.86 | 0.97 | 2.70 | 1.10 | 0.00 | 0.40 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 0.56 | 1.51 | 2.58 | 0.00 | 0.98 | 1.15 | 0.00 | 0.00 | 2.34 | 0.00 | 0.95 | 1.08 | 0.00 | 0.20 | 0.00 | 0.67 | 1.82 | 0.00 |
| SLC10A2 | ENSG00000125255 | 2.22 | 2.04 | 0.41 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 2.45 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.81 | 1.56 | 0.00 | 5.92 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| SLC7A8 | ENSG00000092068 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 0.28 | 0.75 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CACNA1H | ENSG00000196557 | 2.22 | 2.80 | 0.83 | 3.28 | 0.00 | 4.52 | 5.41 | 1.66 | 1.29 | 1.79 | 1.54 | 0.54 | 1.78 | 0.74 | 0.78 | 1.39 | 2.26 | 3.43 | 0.00 | 0.25 | 1.72 | 1.12 | 0.00 | 3.13 | 3.02 | 8.29 | 2.98 | 0.69 | 0.00 | 0.83 | 3.99 | 3.64 | 0.00 |
| ADCY7 | ENSG00000121281 | 1.11 | 0.76 | 0.93 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 1.29 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.00 | 1.88 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.13 | 1.36 | 0.00 | 0.20 | 0.83 | 2.22 | 0.00 | 0.00 |
| EVI2B | ENSG00000185862 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.28 | 1.13 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 1.36 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CACNA1A | ENSG00000141837 | 1.11 | 5.60 | 2.27 | 2.19 | 0.00 | 2.90 | 2.70 | 1.66 | 0.52 | 1.79 | 3.08 | 1.36 | 1.78 | 0.74 | 0.20 | 2.22 | 3.58 | 6.65 | 0.00 | 2.45 | 1.15 | 0.56 | 1.63 | 1.56 | 1.29 | 7.82 | 2.44 | 0.00 | 0.41 | 0.00 | 4.43 | 3.64 | 1.25 |
| NOTCH3 | ENSG00000074181 | 3.33 | 3.05 | 0.62 | 2.55 | 0.00 | 2.26 | 5.41 | 6.08 | 0.77 | 3.98 | 0.00 | 1.36 | 1.42 | 0.74 | 0.78 | 2.22 | 1.51 | 3.00 | 1.23 | 0.74 | 0.57 | 0.56 | 0.41 | 1.56 | 1.72 | 4.98 | 1.63 | 2.08 | 0.00 | 0.00 | 6.43 | 0.00 | 0.00 |
| ATP4A | ENSG00000105675 | 0.00 | 0.76 | 0.62 | 0.00 | 0.00 | 1.29 | 0.00 | 0.55 | 1.29 | 1.00 | 0.00 | 1.08 | 0.36 | 0.00 | 0.59 | 1.39 | 2.07 | 3.00 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 3.08 | 1.63 | 1.39 | 0.20 | 0.00 | 2.22 | 3.64 | 0.00 |
| SIGLEC12 | ENSG00000254521 | 1.11 | 1.27 | 0.41 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 3.20 | 2.79 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 4.03 | 0.81 | 0.00 | 0.41 | 0.00 | 1.11 | 0.00 | 0.00 |
| SIGLEC5 | ENSG00000105501 | 2.22 | 1.02 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 2.45 | 2.36 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.86 | 4.27 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| VSTM1 | ENSG00000189068 | 0.00 | 1.27 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| KCNG3 | ENSG00000171126 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.00 | 0.00 | 0.00 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KCNJ3 | ENSG00000162989 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 1.29 | 2.70 | 0.55 | 0.26 | 1.59 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 1.39 | 5.08 | 6.01 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 4.98 | 1.36 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| CD302 | ENSG00000241399 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLC19A3 | ENSG00000135917 | 0.00 | 0.25 | 0.21 | 1.09 | 0.00 | 0.32 | 2.70 | 1.10 | 0.26 | 1.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.56 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
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