Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC22A7 | ENSG00000137204 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.54 | 1.42 | 0.74 | 0.00 | 0.00 | 2.07 | 0.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.43 | 1.18 | 0.27 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC22A1 | ENSG00000175003 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 1.50 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC26A4 | ENSG00000091137 | 0.00 | 1.78 | 0.41 | 1.82 | 0.00 | 0.65 | 2.70 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 1.11 | 2.07 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| MGAM | ENSG00000257335 | 0.00 | 2.04 | 1.55 | 2.55 | 0.00 | 3.87 | 2.70 | 3.31 | 1.80 | 4.98 | 0.00 | 0.81 | 1.78 | 0.00 | 0.59 | 2.22 | 6.78 | 7.08 | 0.00 | 1.47 | 0.57 | 0.56 | 0.41 | 0.78 | 2.59 | 27.96 | 0.27 | 0.00 | 0.41 | 0.00 | 4.88 | 9.09 | 0.00 |
| CHRNB3 | ENSG00000147432 | 1.11 | 1.27 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 1.13 | 2.36 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 2.34 | 0.43 | 3.55 | 1.08 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC1A1 | ENSG00000106688 | 2.22 | 0.51 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC28A3 | ENSG00000197506 | 1.11 | 2.04 | 0.52 | 0.73 | 0.00 | 1.29 | 2.70 | 0.55 | 1.03 | 0.40 | 0.00 | 0.81 | 0.71 | 0.00 | 0.20 | 0.28 | 1.69 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| GRIN3A | ENSG00000198785 | 1.11 | 1.02 | 0.41 | 1.46 | 0.00 | 1.61 | 2.70 | 1.10 | 0.52 | 2.19 | 1.54 | 0.27 | 0.71 | 0.74 | 0.39 | 1.67 | 6.03 | 6.22 | 1.23 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 1.29 | 10.43 | 3.52 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| GLRA2 | ENSG00000101958 | 0.00 | 1.02 | 0.41 | 1.09 | 2.86 | 0.00 | 0.00 | 0.55 | 0.77 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 2.26 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC38A5 | ENSG00000017483 | 0.00 | 0.00 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.83 | 1.55 | 0.00 | 0.00 |
| SLC7A3 | ENSG00000165349 | 0.00 | 0.76 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 1.66 | 1.03 | 0.80 | 1.54 | 0.81 | 0.00 | 0.00 | 0.39 | 0.56 | 0.94 | 1.93 | 1.23 | 0.25 | 1.15 | 0.00 | 0.00 | 1.56 | 0.43 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 2.44 | 3.64 | 0.00 |
| GABRE | ENSG00000102287 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 1.03 | 1.39 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.00 | 0.56 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 5.69 | 1.08 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 1.25 |
| GABRA3 | ENSG00000011677 | 0.00 | 0.25 | 0.31 | 1.09 | 0.00 | 1.29 | 0.00 | 1.10 | 0.77 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 3.01 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 4.74 | 1.36 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CACHD1 | ENSG00000158966 | 0.00 | 2.54 | 0.62 | 1.46 | 0.00 | 1.61 | 0.00 | 0.55 | 0.52 | 1.20 | 0.00 | 0.81 | 0.71 | 0.00 | 0.20 | 0.56 | 2.26 | 0.64 | 0.00 | 0.74 | 0.00 | 0.56 | 0.41 | 0.78 | 0.00 | 2.37 | 1.36 | 0.00 | 0.41 | 0.00 | 1.33 | 0.00 | 1.25 |
| KCNA2 | ENSG00000177301 | 0.00 | 1.78 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.27 | 0.71 | 0.74 | 0.20 | 0.56 | 1.13 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 2.34 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLAMF7 | ENSG00000026751 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TNFSF4 | ENSG00000117586 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.34 | 0.00 | 0.95 | 0.27 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| QSOX1 | ENSG00000116260 | 0.00 | 0.76 | 0.52 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.28 | 0.75 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KCNC1 | ENSG00000129159 | 0.00 | 1.53 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.00 | 1.32 | 1.29 | 1.23 | 0.25 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 1.42 | 1.08 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| ACP2 | ENSG00000134575 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.83 | 0.22 | 0.00 | 1.25 |
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