Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| DUOX2 | ENSG00000140279 | 1.11 | 1.53 | 0.72 | 1.09 | 0.00 | 0.97 | 0.00 | 1.10 | 2.06 | 1.79 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 1.94 | 2.07 | 2.79 | 0.00 | 0.74 | 0.00 | 0.56 | 0.61 | 0.00 | 0.86 | 6.87 | 1.90 | 0.69 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| SLC28A1 | ENSG00000156222 | 1.11 | 0.51 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.60 | 1.54 | 0.27 | 0.71 | 0.74 | 0.39 | 0.00 | 1.13 | 2.58 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.37 | 0.27 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| SCNN1B | ENSG00000168447 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.80 | 0.00 | 0.81 | 1.07 | 0.00 | 0.39 | 0.28 | 0.94 | 1.07 | 0.00 | 0.25 | 0.00 | 0.56 | 0.61 | 0.00 | 1.29 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ABCC11 | ENSG00000121270 | 2.22 | 3.05 | 0.52 | 1.46 | 0.00 | 1.94 | 0.00 | 1.10 | 0.52 | 1.39 | 0.00 | 0.54 | 0.71 | 0.74 | 0.78 | 1.11 | 5.08 | 4.51 | 0.00 | 1.47 | 0.57 | 0.00 | 0.41 | 1.56 | 0.43 | 3.79 | 1.08 | 0.00 | 0.00 | 0.00 | 3.33 | 0.00 | 0.00 |
| SLC12A3 | ENSG00000070915 | 1.11 | 1.27 | 0.31 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 1.88 | 2.36 | 0.00 | 0.74 | 1.15 | 0.00 | 0.00 | 1.56 | 0.86 | 4.03 | 1.08 | 0.00 | 0.00 | 0.83 | 2.22 | 1.82 | 0.00 |
| KCNG4 | ENSG00000168418 | 1.11 | 0.51 | 0.41 | 0.00 | 0.00 | 1.61 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.81 | 0.00 | 0.00 | 0.39 | 0.28 | 0.94 | 2.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 3.55 | 2.17 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| EFNB3 | ENSG00000108947 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| KCNJ12 | ENSG00000184185 | 1.11 | 1.27 | 0.52 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 1.55 | 1.39 | 1.54 | 0.27 | 1.07 | 0.00 | 0.59 | 0.56 | 4.14 | 2.58 | 0.00 | 0.74 | 1.15 | 0.00 | 0.20 | 0.78 | 0.86 | 3.79 | 2.44 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| CACNG4 | ENSG00000075461 | 0.00 | 1.53 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC16A5 | ENSG00000170190 | 0.00 | 0.25 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 1.03 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| TNFSF14 | ENSG00000125735 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 1.25 |
| IL12RB1 | ENSG00000096996 | 0.00 | 0.51 | 0.52 | 0.36 | 0.00 | 1.29 | 2.70 | 0.55 | 0.77 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.83 | 0.38 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| CACNG8 | ENSG00000142408 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.75 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DPP10 | ENSG00000175497 | 1.11 | 3.05 | 0.62 | 1.82 | 0.00 | 1.61 | 2.70 | 3.87 | 3.09 | 5.18 | 0.00 | 1.08 | 0.71 | 0.00 | 0.39 | 1.67 | 4.52 | 7.51 | 0.00 | 1.72 | 1.15 | 0.00 | 0.81 | 4.69 | 0.00 | 4.98 | 4.07 | 0.00 | 0.00 | 0.00 | 0.44 | 5.45 | 0.00 |
| SLC4A10 | ENSG00000144290 | 1.11 | 2.04 | 0.52 | 1.09 | 0.00 | 1.61 | 0.00 | 1.10 | 1.03 | 1.79 | 1.54 | 0.54 | 0.36 | 0.00 | 0.00 | 1.39 | 3.77 | 3.43 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 5.45 | 2.44 | 0.69 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| SLC52A3 | ENSG00000101276 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 1.13 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.86 | 1.18 | 0.00 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| SIRPG | ENSG00000089012 | 0.00 | 0.76 | 0.62 | 0.00 | 0.00 | 0.00 | 0.00 | 2.21 | 1.29 | 0.80 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 1.11 | 3.01 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.55 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| CD93 | ENSG00000125810 | 1.11 | 1.53 | 0.62 | 0.36 | 0.00 | 1.61 | 0.00 | 1.66 | 0.52 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 2.07 | 2.15 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 4.03 | 2.17 | 0.00 | 0.20 | 0.00 | 4.43 | 0.00 | 0.00 |
| KCNS1 | ENSG00000124134 | 1.11 | 0.76 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GRIK1 | ENSG00000171189 | 2.22 | 2.04 | 1.34 | 1.46 | 0.00 | 1.61 | 0.00 | 1.10 | 0.77 | 1.00 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.83 | 3.20 | 1.93 | 0.00 | 0.98 | 0.00 | 0.56 | 0.61 | 0.78 | 0.43 | 5.45 | 2.98 | 0.00 | 0.41 | 0.00 | 2.88 | 0.00 | 0.00 |
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