Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KIR2DL1 | ENSG00000125498 | 1.11 | 0.00 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.77 | 1.00 | 1.54 | 0.54 | 0.00 | 0.00 | 0.78 | 1.11 | 2.07 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 4.03 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 1.25 |
| KIR3DL2 | ENSG00000240403 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 1.99 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 4.27 | 0.54 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 1.25 |
| ABCG5 | ENSG00000138075 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 1.03 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 1.39 | 2.45 | 0.43 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TGFA | ENSG00000163235 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 1.29 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CD8A | ENSG00000153563 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IL18RAP | ENSG00000115607 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 1.55 | 0.80 | 1.54 | 0.54 | 0.00 | 0.00 | 0.20 | 1.11 | 3.39 | 1.93 | 0.00 | 0.49 | 0.57 | 0.56 | 0.00 | 0.78 | 0.43 | 4.98 | 0.00 | 0.69 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| CHRNA4 | ENSG00000101204 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.77 | 0.80 | 0.00 | 0.54 | 1.07 | 0.00 | 0.39 | 1.39 | 2.64 | 2.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 2.84 | 1.90 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| TMPRSS6 | ENSG00000187045 | 1.11 | 1.27 | 0.41 | 1.09 | 0.00 | 0.97 | 0.00 | 1.66 | 2.32 | 0.60 | 0.00 | 0.81 | 0.71 | 0.00 | 0.39 | 0.56 | 0.75 | 1.50 | 0.00 | 0.74 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| MUC13 | ENSG00000173702 | 1.11 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 1.66 | 0.52 | 0.80 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.00 | 0.94 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TMPRSS11D | ENSG00000153802 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 1.11 | 1.32 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.61 | 0.00 | 0.43 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| EREG | ENSG00000124882 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| BTC | ENSG00000174808 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GABRB2 | ENSG00000145864 | 1.11 | 1.27 | 0.41 | 0.73 | 0.00 | 1.29 | 2.70 | 0.00 | 2.06 | 1.39 | 0.00 | 0.00 | 1.07 | 0.00 | 0.39 | 0.56 | 0.94 | 2.15 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 2.34 | 0.00 | 6.87 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| BTN3A2 | ENSG00000186470 | 0.00 | 0.00 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 1.32 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GRIK2 | ENSG00000164418 | 0.00 | 3.31 | 1.45 | 1.09 | 5.71 | 2.58 | 0.00 | 1.10 | 0.77 | 2.79 | 0.00 | 1.08 | 0.36 | 0.74 | 0.39 | 1.67 | 5.84 | 5.15 | 0.00 | 0.98 | 1.72 | 0.00 | 0.00 | 3.13 | 0.86 | 5.92 | 2.44 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| KEL | ENSG00000197993 | 1.11 | 1.78 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 4.38 | 1.00 | 0.00 | 0.54 | 0.71 | 0.00 | 1.57 | 0.83 | 3.77 | 2.36 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 1.56 | 0.86 | 9.95 | 0.54 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| NRG1 | ENSG00000157168 | 0.00 | 2.29 | 0.31 | 0.36 | 0.00 | 3.23 | 0.00 | 5.52 | 1.29 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.83 | 2.07 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 4.27 | 1.90 | 0.00 | 0.00 | 0.83 | 1.77 | 1.82 | 0.00 |
| IL1RAPL1 | ENSG00000169306 | 0.00 | 2.04 | 0.62 | 1.82 | 0.00 | 2.26 | 0.00 | 1.10 | 0.52 | 2.79 | 0.00 | 0.00 | 0.36 | 0.74 | 0.59 | 0.56 | 4.90 | 4.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.13 | 1.63 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| GPR119 | ENSG00000147262 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 1.13 | 0.21 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 0.54 | 0.00 | 0.20 | 0.83 | 0.67 | 0.00 | 0.00 |
| IL9R | ENSG00000124334 | 0.00 | 0.25 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 1.11 | 3.58 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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