Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| P2RY4 | ENSG00000186912 | 0.00 | 0.00 | 0.21 | 1.09 | 0.00 | 1.61 | 2.70 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.94 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR13H1 | ENSG00000171054 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.83 | 1.69 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| BRS3 | ENSG00000102239 | 0.00 | 0.76 | 0.21 | 1.46 | 0.00 | 1.29 | 0.00 | 0.55 | 0.26 | 0.80 | 1.54 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 1.13 | 0.43 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.27 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| GPR101 | ENSG00000165370 | 0.00 | 1.53 | 0.62 | 0.36 | 0.00 | 0.97 | 5.41 | 0.00 | 0.77 | 1.20 | 1.54 | 0.54 | 0.00 | 0.74 | 0.20 | 1.39 | 3.20 | 0.64 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.66 | 1.63 | 0.00 | 0.61 | 0.00 | 1.55 | 0.00 | 0.00 |
| TNFRSF18 | ENSG00000186891 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SELE | ENSG00000007908 | 1.11 | 0.76 | 0.21 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 1.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.98 | 0.28 | 2.26 | 2.36 | 1.23 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 4.50 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 2.50 |
| CRB1 | ENSG00000134376 | 1.11 | 3.31 | 1.34 | 1.82 | 0.00 | 1.29 | 2.70 | 4.97 | 0.77 | 4.18 | 0.00 | 1.36 | 0.36 | 0.00 | 0.20 | 2.50 | 9.60 | 9.23 | 0.00 | 2.21 | 0.57 | 0.00 | 0.41 | 4.69 | 0.86 | 13.98 | 3.52 | 0.69 | 0.20 | 0.00 | 2.88 | 1.82 | 0.00 |
| KCNMA1 | ENSG00000156113 | 0.00 | 2.04 | 0.41 | 1.46 | 0.00 | 0.97 | 0.00 | 3.87 | 0.52 | 0.60 | 1.54 | 0.27 | 0.36 | 0.74 | 0.59 | 0.56 | 2.07 | 2.36 | 1.23 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.08 | 2.98 | 0.69 | 0.20 | 0.00 | 3.33 | 1.82 | 0.00 |
| SLC16A12 | ENSG00000152779 | 0.00 | 0.25 | 0.21 | 0.73 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.56 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR52J3 | ENSG00000205495 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 0.26 | 0.60 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.00 | 2.07 | 2.58 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 4.27 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GRIN2B | ENSG00000273079 | 2.22 | 1.78 | 1.45 | 2.19 | 0.00 | 1.29 | 2.70 | 1.10 | 1.80 | 3.78 | 0.00 | 2.17 | 0.36 | 0.74 | 0.78 | 1.11 | 8.10 | 8.15 | 1.23 | 0.98 | 0.57 | 0.00 | 1.22 | 0.00 | 0.00 | 11.14 | 1.36 | 0.69 | 0.81 | 0.83 | 2.88 | 0.00 | 1.25 |
| ACVRL1 | ENSG00000139567 | 1.11 | 1.27 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 1.03 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.78 | 0.56 | 1.32 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.78 | 0.43 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR10A7 | ENSG00000179919 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.39 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.84 | 0.54 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| TNFSF11 | ENSG00000120659 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 1.03 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ATP4B | ENSG00000186009 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SLC52A1 | ENSG00000132517 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.00 | 0.57 | 0.56 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SCN4A | ENSG00000007314 | 0.00 | 2.80 | 1.14 | 0.73 | 2.86 | 1.94 | 2.70 | 1.10 | 0.52 | 1.79 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 1.11 | 4.33 | 5.36 | 0.00 | 0.49 | 0.57 | 0.56 | 1.02 | 0.78 | 2.59 | 4.74 | 1.63 | 0.00 | 0.00 | 0.83 | 3.55 | 0.00 | 0.00 |
| ICAM4 | ENSG00000105371 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| EPOR | ENSG00000187266 | 0.00 | 1.27 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.20 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.00 | 0.43 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| FLT3LG | ENSG00000090554 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.69 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
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