Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR13F1 | ENSG00000186881 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 2.45 | 1.50 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 2.61 | 1.36 | 0.00 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR13C4 | ENSG00000148136 | 0.00 | 0.25 | 0.62 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.51 | 1.93 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.13 | 1.90 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR13C3 | ENSG00000204246 | 2.22 | 1.53 | 0.00 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.94 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 2.34 | 0.00 | 4.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR13C8 | ENSG00000186943 | 0.00 | 0.76 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 1.93 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 4.98 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR13D1 | ENSG00000179055 | 1.11 | 0.00 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 1.13 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR1J1 | ENSG00000136834 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.75 | 1.07 | 1.23 | 0.49 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR1J2 | ENSG00000197233 | 0.00 | 0.76 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 1.66 | 0.81 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR1J4 | ENSG00000239590 | 1.11 | 0.00 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.32 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR1N1 | ENSG00000171505 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 0.28 | 0.75 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR1N2 | ENSG00000171501 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 1.51 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 5.21 | 0.81 | 0.00 | 0.41 | 0.00 | 0.22 | 1.82 | 0.00 |
| OR1L8 | ENSG00000171496 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.56 | 1.51 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.32 | 0.81 | 0.69 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR1Q1 | ENSG00000165202 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.40 | 1.54 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.51 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR1L1 | ENSG00000173679 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.84 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR1L3 | ENSG00000171481 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 1.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR1L4 | ENSG00000136939 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.26 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.13 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR1L6 | ENSG00000171459 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR5C1 | ENSG00000148215 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.81 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 1.25 |
| GPR21 | ENSG00000188394 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GRIN1 | ENSG00000176884 | 1.11 | 1.02 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 1.67 | 1.32 | 2.36 | 1.23 | 0.25 | 0.00 | 0.56 | 0.41 | 0.00 | 0.86 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GPR143 | ENSG00000101850 | 0.00 | 0.25 | 0.52 | 0.73 | 0.00 | 0.65 | 2.70 | 0.00 | 0.77 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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