Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR2A4 | ENSG00000180658 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TAAR9 | ENSG00000237110 | 1.11 | 0.51 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.00 | 1.69 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.00 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TAAR8 | ENSG00000146385 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.75 | 2.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TAAR1 | ENSG00000146399 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| MAS1 | ENSG00000130368 | 0.00 | 0.51 | 0.31 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CCR6 | ENSG00000112486 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 1.32 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 0.22 | 1.82 | 0.00 |
| GPER1 | ENSG00000164850 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.56 | 0.86 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| GHRHR | ENSG00000106128 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ADCYAP1R1 | ENSG00000078549 | 1.11 | 1.27 | 0.31 | 0.36 | 0.00 | 0.97 | 2.70 | 0.55 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.11 | 1.69 | 2.79 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 4.27 | 0.81 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| NPSR1 | ENSG00000187258 | 1.11 | 0.76 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 2.26 | 1.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.69 | 0.81 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| FZD9 | ENSG00000188763 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.83 | 0.56 | 1.50 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| OR2AE1 | ENSG00000244623 | 1.11 | 0.25 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GRM8 | ENSG00000179603 | 1.11 | 1.02 | 0.83 | 1.46 | 0.00 | 1.29 | 0.00 | 4.97 | 1.80 | 3.59 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.94 | 7.53 | 8.37 | 1.23 | 1.72 | 2.30 | 0.00 | 0.41 | 1.56 | 0.86 | 9.72 | 4.07 | 0.69 | 0.00 | 0.83 | 4.21 | 0.00 | 0.00 |
| OR9A4 | ENSG00000258083 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.65 | 2.70 | 0.55 | 0.52 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.79 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR9A2 | ENSG00000179468 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 1.51 | 2.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 3.08 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR6V1 | ENSG00000225781 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR6B1 | ENSG00000221813 | 0.00 | 1.27 | 0.52 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 1.69 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.84 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| HTR5A | ENSG00000157219 | 1.11 | 0.51 | 0.31 | 0.00 | 2.86 | 1.29 | 0.00 | 0.00 | 1.29 | 1.59 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 2.26 | 3.22 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 4.50 | 1.08 | 0.69 | 0.20 | 0.00 | 2.22 | 1.82 | 0.00 |
| ADRB3 | ENSG00000188778 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GPR20 | ENSG00000204882 | 1.11 | 0.51 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.61 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
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