Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR7G2 | ENSG00000170923 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 1.29 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.51 | 0.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR7G3 | ENSG00000170920 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR7D2 | ENSG00000188000 | 0.00 | 0.00 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 3.55 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR7E24 | ENSG00000237521 | 1.11 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 1.32 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR7A5 | ENSG00000188269 | 0.00 | 0.76 | 0.52 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 0.94 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 0.71 | 0.54 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR7C1 | ENSG00000127530 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.86 | 0.24 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR7A10 | ENSG00000127515 | 1.11 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 2.70 | 0.00 | 0.26 | 0.00 | 0.00 | 0.54 | 0.36 | 0.74 | 0.00 | 0.56 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR7C2 | ENSG00000127529 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.32 | 1.50 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.78 | 0.86 | 2.13 | 0.00 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| OR1I1 | ENSG00000094661 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| OR10H3 | ENSG00000171936 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.65 | 2.70 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.64 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SCN1B | ENSG00000105711 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| FFAR2 | ENSG00000126262 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 1.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.19 | 0.43 | 0.00 | 0.00 | 0.57 | 0.56 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| C5AR2 | ENSG00000134830 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.56 | 0.19 | 0.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| VN1R2 | ENSG00000196131 | 2.22 | 0.51 | 0.31 | 0.73 | 0.00 | 0.65 | 2.70 | 1.66 | 0.26 | 0.80 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 1.11 | 2.64 | 1.72 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| LHCGR | ENSG00000138039 | 0.00 | 1.78 | 0.62 | 0.00 | 0.00 | 0.97 | 0.00 | 1.66 | 0.52 | 1.59 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.39 | 2.45 | 3.86 | 0.00 | 1.47 | 0.57 | 0.00 | 0.20 | 0.00 | 0.86 | 5.92 | 2.17 | 0.69 | 0.00 | 0.00 | 2.00 | 3.64 | 0.00 |
| PROKR1 | ENSG00000169618 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 1.29 | 2.70 | 0.00 | 0.00 | 0.60 | 0.00 | 0.54 | 0.00 | 0.74 | 0.78 | 0.28 | 2.07 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GPR45 | ENSG00000135973 | 0.00 | 0.51 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 2.07 | 1.07 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 1.63 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| GPR148 | ENSG00000173302 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 2.45 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SCN9A | ENSG00000169432 | 1.11 | 2.54 | 1.24 | 2.55 | 0.00 | 6.13 | 8.11 | 4.42 | 3.87 | 2.79 | 0.00 | 1.63 | 0.71 | 0.74 | 0.20 | 1.94 | 3.95 | 4.51 | 1.23 | 1.47 | 2.30 | 0.00 | 0.00 | 5.47 | 2.59 | 13.27 | 4.61 | 1.39 | 0.41 | 0.00 | 3.77 | 0.00 | 1.25 |
| FZD5 | ENSG00000163251 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.28 | 0.94 | 0.00 | 1.23 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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