Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR5J2 | ENSG00000174957 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 1.66 | 0.52 | 1.99 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.56 | 4.14 | 3.65 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 4.03 | 1.63 | 0.69 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR5T3 | ENSG00000172489 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 1.29 | 0.00 | 1.66 | 0.26 | 1.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.98 | 0.56 | 4.14 | 3.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 3.32 | 1.90 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR8H1 | ENSG00000181693 | 0.00 | 1.53 | 0.31 | 0.73 | 0.00 | 0.65 | 2.70 | 1.66 | 0.52 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 2.82 | 2.79 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.90 | 1.63 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR8K1 | ENSG00000150261 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 0.56 | 2.07 | 2.15 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 1.56 | 0.43 | 1.66 | 1.36 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR8J1 | ENSG00000172487 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.97 | 2.70 | 0.55 | 0.00 | 1.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 3.20 | 3.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR5M9 | ENSG00000150269 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 2.21 | 0.77 | 1.00 | 1.54 | 0.00 | 0.00 | 0.00 | 0.59 | 0.56 | 1.88 | 2.79 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.37 | 1.63 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR5M3 | ENSG00000174937 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 2.76 | 0.52 | 1.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.28 | 2.64 | 2.36 | 1.23 | 1.23 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 2.71 | 0.00 | 0.41 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR5M8 | ENSG00000181371 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 1.61 | 2.70 | 1.10 | 0.52 | 1.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.28 | 1.69 | 2.79 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 2.13 | 1.63 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR5M11 | ENSG00000255223 | 1.11 | 0.76 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 1.39 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 2.07 | 1.93 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR5M10 | ENSG00000254834 | 1.11 | 2.04 | 0.00 | 0.36 | 0.00 | 0.00 | 5.41 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 1.11 | 1.69 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 1.29 | 2.61 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR5AP2 | ENSG00000172464 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 1.29 | 2.70 | 0.00 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 1.51 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 1.29 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR9G1 | ENSG00000174914 | 0.00 | 0.51 | 0.41 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.78 | 0.83 | 1.88 | 4.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR9G4 | ENSG00000172457 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.80 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.28 | 1.88 | 3.22 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| OR5AK2 | ENSG00000181273 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 1.07 | 1.23 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 3.32 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR9Q1 | ENSG00000186509 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.28 | 0.75 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR9I1 | ENSG00000172377 | 0.00 | 1.53 | 0.00 | 0.36 | 2.86 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.56 | 2.36 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR9Q2 | ENSG00000186513 | 1.11 | 1.02 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 1.13 | 2.79 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| OR1S2 | ENSG00000197887 | 1.11 | 0.76 | 0.31 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 1.54 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 2.26 | 3.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 1.29 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR5B17 | ENSG00000197786 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 2.07 | 2.36 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 2.13 | 0.54 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR5B3 | ENSG00000172769 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 2.26 | 3.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.37 | 0.54 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
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