Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR4C3 | ENSG00000176547 | 1.11 | 1.02 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 1.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 2.45 | 3.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 4.27 | 0.81 | 0.00 | 0.20 | 0.00 | 0.89 | 1.82 | 0.00 |
| OR4A47 | ENSG00000237388 | 0.00 | 1.53 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 2.45 | 1.72 | 0.00 | 0.74 | 1.15 | 0.00 | 0.00 | 0.78 | 0.86 | 3.79 | 2.17 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR4C13 | ENSG00000258817 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 3.01 | 4.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.61 | 2.34 | 0.43 | 4.50 | 1.90 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| OR4C46 | ENSG00000185926 | 0.00 | 1.78 | 0.52 | 0.00 | 0.00 | 0.65 | 2.70 | 1.10 | 0.52 | 1.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.28 | 4.52 | 3.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 4.27 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR4C15 | ENSG00000181939 | 0.00 | 1.02 | 0.72 | 1.46 | 0.00 | 0.97 | 0.00 | 2.21 | 1.03 | 1.39 | 0.00 | 0.54 | 0.36 | 0.00 | 0.59 | 0.56 | 6.03 | 5.36 | 1.23 | 0.49 | 0.57 | 0.00 | 0.00 | 1.56 | 0.43 | 6.40 | 3.25 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR4C11 | ENSG00000172188 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 1.66 | 0.52 | 1.20 | 0.00 | 0.27 | 1.07 | 0.00 | 0.20 | 0.56 | 2.26 | 4.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 2.13 | 1.63 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR4S2 | ENSG00000174982 | 0.00 | 0.76 | 0.62 | 0.36 | 0.00 | 0.65 | 0.00 | 1.66 | 0.52 | 1.00 | 0.00 | 0.54 | 0.00 | 0.74 | 0.59 | 0.56 | 3.39 | 4.08 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 1.56 | 0.00 | 3.32 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR4C6 | ENSG00000181903 | 1.11 | 1.02 | 0.10 | 0.36 | 0.00 | 1.29 | 2.70 | 1.66 | 0.77 | 1.99 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.56 | 4.14 | 5.79 | 0.00 | 0.25 | 1.15 | 0.00 | 0.41 | 0.00 | 0.00 | 4.27 | 2.17 | 0.69 | 0.20 | 0.00 | 1.33 | 1.82 | 0.00 |
| OR5D14 | ENSG00000186113 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 1.29 | 0.00 | 2.21 | 1.03 | 1.59 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 1.39 | 4.52 | 4.51 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.90 | 2.17 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| OR5D18 | ENSG00000186119 | 1.11 | 1.27 | 0.31 | 0.00 | 0.00 | 1.94 | 0.00 | 1.66 | 1.55 | 1.79 | 1.54 | 0.27 | 0.00 | 0.00 | 0.39 | 1.67 | 3.39 | 6.01 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 2.34 | 0.43 | 2.84 | 0.54 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| OR5L2 | ENSG00000205030 | 0.00 | 1.78 | 0.41 | 0.73 | 2.86 | 1.61 | 0.00 | 4.42 | 0.77 | 1.79 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 5.27 | 4.94 | 0.00 | 1.23 | 0.57 | 0.00 | 0.61 | 0.00 | 0.00 | 2.13 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 1.25 |
| OR5D16 | ENSG00000205029 | 0.00 | 1.02 | 0.31 | 0.73 | 2.86 | 0.32 | 2.70 | 2.21 | 1.03 | 1.79 | 0.00 | 0.00 | 0.71 | 0.74 | 0.20 | 0.00 | 3.77 | 4.51 | 0.00 | 1.23 | 0.00 | 0.00 | 0.61 | 1.56 | 0.00 | 1.90 | 1.90 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR5I1 | ENSG00000167825 | 0.00 | 1.02 | 0.72 | 0.73 | 0.00 | 1.61 | 0.00 | 1.66 | 1.03 | 1.99 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 1.39 | 3.20 | 3.65 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 1.36 | 0.00 | 0.20 | 0.00 | 0.67 | 1.82 | 0.00 |
| OR5F1 | ENSG00000149133 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.52 | 1.59 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 4.33 | 4.51 | 2.47 | 0.74 | 0.57 | 0.00 | 0.41 | 0.00 | 0.43 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| OR5AS1 | ENSG00000181785 | 0.00 | 1.53 | 0.31 | 0.36 | 0.00 | 1.29 | 0.00 | 1.66 | 0.52 | 1.39 | 0.00 | 0.27 | 0.36 | 0.74 | 0.39 | 0.28 | 3.95 | 2.58 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 2.37 | 1.36 | 0.00 | 0.20 | 0.00 | 2.00 | 1.82 | 0.00 |
| OR8I2 | ENSG00000172154 | 0.00 | 1.53 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 2.21 | 0.77 | 1.59 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 3.95 | 4.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.55 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR8H2 | ENSG00000181767 | 1.11 | 1.27 | 0.62 | 1.09 | 0.00 | 0.65 | 0.00 | 1.66 | 1.03 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.94 | 4.52 | 4.72 | 1.23 | 0.25 | 0.57 | 0.00 | 0.41 | 0.78 | 0.86 | 4.27 | 0.54 | 0.00 | 0.41 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR8H3 | ENSG00000181761 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 2.76 | 0.77 | 1.39 | 0.00 | 0.00 | 0.71 | 0.00 | 0.59 | 0.00 | 2.82 | 3.43 | 1.23 | 1.23 | 0.57 | 0.56 | 0.00 | 2.34 | 0.00 | 4.50 | 1.90 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR8J3 | ENSG00000167822 | 0.00 | 1.53 | 0.00 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 2.19 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.56 | 4.14 | 4.08 | 0.00 | 0.00 | 0.57 | 1.12 | 0.00 | 0.00 | 0.00 | 1.66 | 2.17 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR8K5 | ENSG00000181752 | 0.00 | 1.02 | 0.21 | 1.46 | 0.00 | 0.97 | 2.70 | 1.66 | 0.00 | 1.39 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 3.20 | 4.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.66 | 0.81 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
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