Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| OR6K2 | ENSG00000196171 | 0.00 | 0.51 | 0.62 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 1.39 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.56 | 3.39 | 3.65 | 1.23 | 0.25 | 0.00 | 0.00 | 0.61 | 1.56 | 0.00 | 2.37 | 0.54 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| OR6K3 | ENSG00000203757 | 0.00 | 1.27 | 0.62 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 1.51 | 3.65 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 3.32 | 1.63 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR6K6 | ENSG00000180433 | 1.11 | 1.27 | 0.41 | 0.36 | 0.00 | 0.00 | 2.70 | 2.76 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 2.45 | 2.36 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 3.79 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR6N2 | ENSG00000188340 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 1.00 | 1.54 | 0.00 | 0.00 | 0.74 | 0.39 | 0.83 | 2.64 | 2.36 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 1.66 | 1.90 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| GPR25 | ENSG00000170128 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| AVPR1B | ENSG00000198049 | 0.00 | 0.51 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 1.03 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.29 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.13 | 0.27 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR2G2 | ENSG00000177489 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 1.66 | 0.26 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 1.67 | 5.08 | 3.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 4.03 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR2G3 | ENSG00000177476 | 1.11 | 0.51 | 0.62 | 0.73 | 0.00 | 0.97 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.58 | 4.51 | 0.00 | 0.74 | 1.15 | 0.00 | 0.00 | 0.00 | 0.86 | 4.50 | 1.90 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR6F1 | ENSG00000169214 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 1.39 | 1.54 | 0.54 | 0.00 | 0.74 | 0.39 | 0.56 | 4.52 | 5.58 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 3.55 | 1.63 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR14A16 | ENSG00000196772 | 0.00 | 0.51 | 0.52 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 1.03 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 1.39 | 4.14 | 3.00 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 4.50 | 1.63 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| OR11L1 | ENSG00000197591 | 0.00 | 0.51 | 0.62 | 0.73 | 0.00 | 0.65 | 0.00 | 1.66 | 0.26 | 1.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.83 | 2.64 | 4.72 | 0.00 | 0.25 | 1.15 | 0.00 | 0.41 | 0.78 | 0.43 | 4.50 | 1.90 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OR2T8 | ENSG00000177462 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 2.26 | 3.22 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 1.90 | 1.08 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| OR2AK2 | ENSG00000187080 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.65 | 2.70 | 1.10 | 0.26 | 1.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 3.77 | 4.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 2.17 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR2M5 | ENSG00000162727 | 0.00 | 1.78 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 1.29 | 2.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.56 | 4.90 | 4.08 | 0.00 | 0.98 | 1.15 | 0.00 | 0.00 | 2.34 | 0.00 | 4.74 | 3.52 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| OR2M2 | ENSG00000198601 | 1.11 | 0.76 | 0.31 | 0.73 | 0.00 | 2.58 | 2.70 | 2.76 | 1.03 | 1.79 | 3.08 | 0.54 | 0.36 | 0.00 | 0.20 | 0.56 | 3.39 | 4.08 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 3.13 | 0.43 | 4.50 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| OR2M3 | ENSG00000228198 | 0.00 | 1.53 | 0.00 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 1.29 | 1.39 | 0.00 | 0.00 | 0.36 | 0.00 | 0.78 | 1.39 | 6.21 | 6.44 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 1.56 | 0.86 | 4.74 | 2.17 | 0.00 | 0.61 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR2T12 | ENSG00000177201 | 0.00 | 1.53 | 0.31 | 0.00 | 2.86 | 1.29 | 0.00 | 0.55 | 1.80 | 2.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 1.39 | 3.95 | 3.22 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 4.50 | 3.52 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| OR2M7 | ENSG00000177186 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 1.66 | 0.00 | 1.79 | 0.00 | 0.00 | 0.36 | 0.00 | 0.59 | 0.83 | 4.14 | 4.08 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 2.61 | 1.36 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| OR2T4 | ENSG00000196944 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 1.66 | 1.03 | 1.59 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 1.67 | 4.33 | 6.22 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.61 | 1.63 | 0.00 | 0.20 | 0.00 | 0.67 | 1.82 | 0.00 |
| OR2T1 | ENSG00000175143 | 0.00 | 1.02 | 0.62 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 1.59 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.83 | 3.39 | 4.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 4.03 | 1.36 | 0.00 | 0.00 | 0.83 | 1.11 | 1.82 | 0.00 |
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