Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CHRM2 | ENSG00000181072 | 0.00 | 1.02 | 0.31 | 0.36 | 2.86 | 2.90 | 0.00 | 3.87 | 1.03 | 0.60 | 0.00 | 1.36 | 0.36 | 0.00 | 0.00 | 0.83 | 4.71 | 5.58 | 0.00 | 1.47 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 4.74 | 3.25 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| MTNR1B | ENSG00000134640 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.97 | 5.41 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 1.51 | 4.08 | 0.00 | 0.49 | 1.15 | 0.00 | 0.20 | 2.34 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| AVPR1A | ENSG00000166148 | 2.22 | 0.76 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 1.79 | 0.00 | 0.27 | 0.00 | 0.00 | 0.78 | 0.28 | 1.51 | 2.15 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HTR2A | ENSG00000102468 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.65 | 2.70 | 1.10 | 1.03 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 0.94 | 1.72 | 0.00 | 0.74 | 1.15 | 0.00 | 0.41 | 0.78 | 0.43 | 1.90 | 1.63 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| RHCG | ENSG00000140519 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.83 | 0.94 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 3.64 | 0.00 |
| SLC6A4 | ENSG00000108576 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.00 | 1.07 | 0.00 | 0.78 | 0.56 | 0.94 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC4A4 | ENSG00000080493 | 2.22 | 2.80 | 1.03 | 2.19 | 0.00 | 0.65 | 2.70 | 0.00 | 1.03 | 4.58 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.28 | 2.07 | 2.58 | 1.23 | 0.98 | 0.00 | 0.00 | 0.20 | 1.56 | 0.86 | 3.08 | 1.08 | 0.00 | 0.00 | 0.83 | 1.55 | 0.00 | 0.00 |
| NPY2R | ENSG00000185149 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 2.26 | 2.70 | 0.55 | 0.00 | 1.00 | 1.54 | 0.00 | 0.71 | 0.00 | 0.20 | 0.83 | 2.64 | 2.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 3.55 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| GLRA1 | ENSG00000145888 | 2.22 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 1.54 | 0.27 | 0.71 | 0.00 | 0.20 | 0.56 | 1.32 | 0.86 | 0.00 | 0.98 | 0.57 | 0.00 | 0.41 | 0.78 | 0.86 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TRPV6 | ENSG00000165125 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 3.23 | 0.00 | 0.55 | 2.58 | 1.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.78 | 0.28 | 3.20 | 1.29 | 0.00 | 0.25 | 1.15 | 0.00 | 0.20 | 2.34 | 0.86 | 4.03 | 1.08 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| HTR2C | ENSG00000147246 | 0.00 | 0.51 | 0.52 | 1.46 | 0.00 | 3.55 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 1.11 | 0.75 | 2.36 | 1.23 | 1.23 | 1.15 | 0.00 | 0.41 | 0.78 | 0.43 | 3.32 | 1.63 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| TAS1R3 | ENSG00000169962 | 0.00 | 3.05 | 0.00 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 1.54 | 0.81 | 1.07 | 0.00 | 0.20 | 1.11 | 0.38 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 1.08 | 0.69 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| TAS1R1 | ENSG00000173662 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 1.59 | 1.54 | 0.00 | 0.36 | 0.74 | 0.00 | 0.83 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 2.61 | 0.54 | 0.00 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| TAS1R2 | ENSG00000179002 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 2.90 | 0.00 | 1.10 | 0.77 | 0.80 | 0.00 | 0.54 | 1.42 | 0.00 | 0.39 | 0.83 | 4.33 | 1.29 | 2.47 | 0.49 | 0.00 | 0.00 | 0.61 | 1.56 | 0.00 | 4.50 | 2.44 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| HTR6 | ENSG00000158748 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GPR3 | ENSG00000181773 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PTGFR | ENSG00000122420 | 0.00 | 1.78 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 2.07 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.32 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GPR61 | ENSG00000156097 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| OR6Y1 | ENSG00000197532 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 2.21 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 1.11 | 2.82 | 2.58 | 0.00 | 0.49 | 0.57 | 0.56 | 0.20 | 0.00 | 0.00 | 1.66 | 2.44 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR6P1 | ENSG00000186440 | 0.00 | 0.00 | 0.21 | 0.36 | 2.86 | 1.29 | 0.00 | 1.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.39 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
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