Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GPC3 | ENSG00000147257 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.65 | 2.70 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| SLC6A8 | ENSG00000130821 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 1.13 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.41 | 0.00 | 0.44 | 0.00 | 0.00 |
| CEACAM8 | ENSG00000124469 | 0.00 | 1.78 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.94 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ALPPL2 | ENSG00000163286 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.32 | 5.41 | 0.00 | 1.03 | 1.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 0.75 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLIT2 | ENSG00000145147 | 3.33 | 3.82 | 1.34 | 1.82 | 2.86 | 2.58 | 0.00 | 2.76 | 1.03 | 4.38 | 0.00 | 1.08 | 0.36 | 3.68 | 0.78 | 1.94 | 6.40 | 6.22 | 0.00 | 1.96 | 1.15 | 0.00 | 0.20 | 3.13 | 1.29 | 11.85 | 5.15 | 0.00 | 0.20 | 0.00 | 2.44 | 0.00 | 1.25 |
| ALPI | ENSG00000163295 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.28 | 1.32 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.13 | 0.81 | 0.69 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| PLAU | ENSG00000122861 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 1.66 | 0.26 | 0.60 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLIT3 | ENSG00000184347 | 0.00 | 1.78 | 0.31 | 2.55 | 0.00 | 3.23 | 0.00 | 1.66 | 3.35 | 1.59 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 1.39 | 4.90 | 5.58 | 1.23 | 0.49 | 0.57 | 0.00 | 0.81 | 0.78 | 0.86 | 9.95 | 1.90 | 0.69 | 0.20 | 0.83 | 3.77 | 0.00 | 0.00 |
| SEMA3C | ENSG00000075223 | 0.00 | 1.53 | 0.62 | 1.09 | 0.00 | 1.29 | 8.11 | 0.55 | 2.84 | 1.20 | 1.54 | 0.27 | 0.00 | 0.00 | 0.20 | 1.39 | 2.26 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| LAMC1 | ENSG00000135862 | 0.00 | 2.04 | 1.03 | 2.55 | 0.00 | 0.65 | 0.00 | 2.21 | 0.52 | 1.99 | 0.00 | 1.36 | 1.07 | 0.74 | 0.20 | 1.11 | 4.33 | 3.22 | 0.00 | 2.45 | 0.57 | 0.56 | 0.81 | 0.00 | 0.43 | 2.61 | 1.90 | 0.00 | 0.20 | 0.00 | 4.21 | 1.82 | 0.00 |
| COL6A2 | ENSG00000142173 | 1.11 | 1.02 | 0.62 | 1.09 | 0.00 | 1.61 | 0.00 | 2.21 | 1.55 | 1.79 | 0.00 | 1.63 | 1.42 | 0.00 | 0.20 | 1.11 | 3.01 | 1.72 | 1.23 | 0.25 | 3.45 | 0.00 | 0.00 | 0.78 | 0.00 | 3.79 | 2.17 | 0.00 | 0.61 | 0.00 | 3.99 | 0.00 | 0.00 |
| FGA | ENSG00000171560 | 0.00 | 2.80 | 0.41 | 1.09 | 0.00 | 1.29 | 0.00 | 1.10 | 1.55 | 1.99 | 1.54 | 0.54 | 0.00 | 0.00 | 0.59 | 3.06 | 2.45 | 3.00 | 0.00 | 0.98 | 0.00 | 0.00 | 0.81 | 2.34 | 0.86 | 7.35 | 1.08 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| THBS2 | ENSG00000186340 | 0.00 | 2.80 | 0.52 | 1.46 | 0.00 | 3.55 | 0.00 | 1.66 | 0.52 | 1.79 | 0.00 | 0.27 | 0.71 | 0.00 | 0.39 | 1.39 | 4.33 | 6.01 | 0.00 | 1.96 | 0.00 | 0.56 | 0.00 | 1.56 | 0.00 | 3.55 | 1.63 | 0.00 | 0.41 | 0.00 | 2.88 | 0.00 | 1.25 |
| C5AR1 | ENSG00000197405 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 1.07 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TACR1 | ENSG00000115353 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 2.15 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| P2RY1 | ENSG00000169860 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 1.11 | 0.38 | 0.86 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CHRM4 | ENSG00000180720 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 1.18 | 0.27 | 0.00 | 0.20 | 0.00 | 2.22 | 0.00 | 0.00 |
| CCR2 | ENSG00000121807 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 1.54 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.94 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 4.50 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CCKAR | ENSG00000163394 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.56 | 2.07 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 2.34 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CNR1 | ENSG00000118432 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 2.45 | 3.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 1.56 | 1.29 | 2.61 | 1.36 | 0.00 | 0.41 | 0.00 | 1.33 | 3.64 | 0.00 |
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