Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TM4SF1 | ENSG00000169908 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| BMPR1B | ENSG00000138696 | 0.00 | 0.76 | 0.52 | 0.73 | 0.00 | 1.61 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 1.51 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| RAET1G | ENSG00000203722 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC26A3 | ENSG00000091138 | 1.11 | 2.04 | 0.52 | 1.82 | 0.00 | 0.65 | 2.70 | 0.55 | 1.55 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.00 | 2.45 | 1.72 | 0.00 | 1.23 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 4.50 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CNTNAP2 | ENSG00000174469 | 0.00 | 4.83 | 0.72 | 3.65 | 0.00 | 4.84 | 2.70 | 3.31 | 4.38 | 4.38 | 0.00 | 1.08 | 0.00 | 0.00 | 0.39 | 2.22 | 9.98 | 11.37 | 3.70 | 3.19 | 1.15 | 0.00 | 0.20 | 4.69 | 0.00 | 17.06 | 5.69 | 0.00 | 0.00 | 0.83 | 5.54 | 0.00 | 0.00 |
| IL3RA | ENSG00000185291 | 0.00 | 1.02 | 0.52 | 2.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.51 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 1.66 | 0.27 | 0.69 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC16A2 | ENSG00000147100 | 0.00 | 0.76 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.43 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 1.18 | 0.81 | 0.00 | 0.00 | 0.83 | 1.11 | 1.82 | 1.25 |
| IL13RA1 | ENSG00000131724 | 1.11 | 0.51 | 0.21 | 0.36 | 0.00 | 0.65 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 0.56 | 0.86 | 1.23 | 0.00 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC44A5 | ENSG00000137968 | 2.22 | 0.76 | 0.62 | 0.73 | 0.00 | 1.94 | 0.00 | 2.21 | 1.03 | 1.00 | 0.00 | 0.81 | 0.00 | 0.74 | 0.20 | 1.94 | 3.95 | 5.79 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 1.29 | 3.55 | 1.63 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC2A13 | ENSG00000151229 | 2.22 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 1.20 | 0.00 | 0.00 | 1.42 | 0.00 | 0.20 | 0.56 | 0.75 | 2.79 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KCNC2 | ENSG00000166006 | 1.11 | 1.53 | 0.31 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 1.55 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 3.58 | 3.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 1.56 | 0.86 | 3.08 | 1.63 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| SLC6A15 | ENSG00000072041 | 0.00 | 2.54 | 0.62 | 0.00 | 0.00 | 1.29 | 2.70 | 0.55 | 0.77 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 1.94 | 3.20 | 2.79 | 1.23 | 0.74 | 0.57 | 0.00 | 0.41 | 2.34 | 0.00 | 0.47 | 2.17 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC8B1 | ENSG00000089060 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 1.42 | 0.54 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| P2RX1 | ENSG00000108405 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| LILRA5 | ENSG00000187116 | 0.00 | 0.51 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| MARCO | ENSG00000019169 | 0.00 | 1.53 | 0.52 | 0.00 | 2.86 | 1.61 | 2.70 | 1.66 | 0.77 | 0.60 | 1.54 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 3.20 | 3.65 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 10.19 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SCN7A | ENSG00000136546 | 1.11 | 1.27 | 1.45 | 4.38 | 2.86 | 3.55 | 5.41 | 3.31 | 1.55 | 2.99 | 0.00 | 0.54 | 0.36 | 0.74 | 0.59 | 1.39 | 5.08 | 6.65 | 0.00 | 1.72 | 0.57 | 0.00 | 1.02 | 3.13 | 0.43 | 8.77 | 2.44 | 0.69 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| SLC6A11 | ENSG00000132164 | 1.11 | 1.02 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 1.66 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.39 | 1.88 | 1.50 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 4.50 | 0.54 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| KCNB2 | ENSG00000182674 | 0.00 | 3.05 | 0.83 | 2.55 | 0.00 | 3.55 | 0.00 | 1.10 | 1.80 | 3.78 | 0.00 | 0.81 | 0.36 | 0.00 | 1.18 | 2.50 | 5.27 | 3.43 | 0.00 | 0.00 | 2.30 | 0.00 | 1.43 | 5.47 | 0.43 | 17.30 | 3.79 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| TENM1 | ENSG00000009694 | 2.22 | 5.34 | 2.48 | 5.11 | 2.86 | 4.52 | 2.70 | 4.97 | 2.58 | 5.98 | 0.00 | 1.63 | 1.07 | 0.00 | 1.57 | 2.78 | 10.36 | 11.59 | 0.00 | 3.92 | 1.15 | 0.56 | 0.00 | 7.03 | 0.86 | 13.98 | 4.88 | 0.00 | 0.61 | 0.00 | 8.65 | 1.82 | 0.00 |
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