Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ADCY6 | ENSG00000174233 | 1.11 | 2.54 | 0.21 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.20 | 0.00 | 0.27 | 1.07 | 0.74 | 0.00 | 0.56 | 1.13 | 1.50 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 3.10 | 1.82 | 0.00 |
| PMEL | ENSG00000185664 | 0.00 | 0.76 | 0.52 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.38 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC39A5 | ENSG00000139540 | 0.00 | 0.76 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| TRHDE | ENSG00000072657 | 0.00 | 3.31 | 1.03 | 1.09 | 2.86 | 2.26 | 0.00 | 5.52 | 2.58 | 3.39 | 0.00 | 0.81 | 1.07 | 0.00 | 0.20 | 0.56 | 5.65 | 8.58 | 0.00 | 0.49 | 0.57 | 0.56 | 0.41 | 0.78 | 2.59 | 11.37 | 3.79 | 0.00 | 0.41 | 0.00 | 1.55 | 3.64 | 0.00 |
| SLC41A2 | ENSG00000136052 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CLEC14A | ENSG00000176435 | 0.00 | 2.04 | 0.52 | 1.82 | 2.86 | 0.32 | 0.00 | 2.21 | 1.03 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 1.51 | 2.36 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 4.74 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SPPL2A | ENSG00000138600 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 1.51 | 0.64 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| NTRK3 | ENSG00000140538 | 1.11 | 1.53 | 0.62 | 1.82 | 2.86 | 2.26 | 2.70 | 2.21 | 1.03 | 1.99 | 0.00 | 0.54 | 1.07 | 0.74 | 0.20 | 1.39 | 6.78 | 4.51 | 0.00 | 0.98 | 0.57 | 0.00 | 0.61 | 2.34 | 0.00 | 4.98 | 2.44 | 0.00 | 0.20 | 0.00 | 2.22 | 1.82 | 0.00 |
| IL21R | ENSG00000103522 | 1.11 | 1.78 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 1.67 | 1.69 | 0.86 | 1.23 | 1.72 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 3.08 | 0.54 | 0.69 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| SLC6A2 | ENSG00000103546 | 0.00 | 0.51 | 0.00 | 1.09 | 0.00 | 1.61 | 0.00 | 0.55 | 0.77 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 0.00 | 1.51 | 1.07 | 1.23 | 1.96 | 1.15 | 0.00 | 0.00 | 2.34 | 0.00 | 1.90 | 0.54 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| TNFRSF13B | ENSG00000240505 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CNTNAP1 | ENSG00000108797 | 1.11 | 2.54 | 0.93 | 1.46 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 1.79 | 0.00 | 1.08 | 0.00 | 0.74 | 0.00 | 0.00 | 1.51 | 1.29 | 0.00 | 0.98 | 0.00 | 0.00 | 0.81 | 0.78 | 0.43 | 3.08 | 1.90 | 0.00 | 0.20 | 0.00 | 2.44 | 0.00 | 0.00 |
| ABCA8 | ENSG00000141338 | 0.00 | 3.31 | 1.76 | 1.46 | 0.00 | 2.26 | 2.70 | 1.10 | 0.77 | 1.79 | 0.00 | 1.08 | 1.07 | 0.00 | 0.59 | 0.28 | 3.20 | 4.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 4.69 | 0.86 | 7.11 | 1.90 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| LRRC4B | ENSG00000131409 | 1.11 | 0.76 | 0.41 | 1.09 | 0.00 | 0.97 | 2.70 | 3.31 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.83 | 2.07 | 3.22 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.37 | 2.44 | 0.69 | 0.00 | 0.00 | 1.11 | 1.82 | 1.25 |
| IL1RL2 | ENSG00000115598 | 0.00 | 0.25 | 0.62 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.54 | 1.42 | 0.00 | 0.39 | 0.56 | 0.75 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.86 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| IL18R1 | ENSG00000115604 | 2.22 | 0.76 | 0.62 | 0.00 | 0.00 | 1.61 | 2.70 | 0.00 | 0.77 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 0.28 | 0.94 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.32 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 1.25 |
| LY75 | ENSG00000054219 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TRPM8 | ENSG00000144481 | 1.11 | 1.27 | 1.03 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.71 | 1.47 | 0.59 | 2.22 | 3.01 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 4.03 | 0.27 | 0.00 | 0.00 | 0.00 | 3.10 | 1.82 | 0.00 |
| IL5RA | ENSG00000091181 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.77 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.28 | 1.51 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.37 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| RYK | ENSG00000163785 | 1.11 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 0.21 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
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