Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| NGFR | ENSG00000064300 | 1.11 | 0.51 | 0.00 | 0.00 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 0.75 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| TMIGD2 | ENSG00000167664 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 1.72 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| NRXN1 | ENSG00000179915 | 1.11 | 5.09 | 0.72 | 1.09 | 0.00 | 7.10 | 2.70 | 3.31 | 1.29 | 5.18 | 0.00 | 1.90 | 1.07 | 1.47 | 0.20 | 1.94 | 13.18 | 8.37 | 0.00 | 1.47 | 1.15 | 0.00 | 0.41 | 3.91 | 2.59 | 12.80 | 7.32 | 0.00 | 0.41 | 1.65 | 3.99 | 7.27 | 1.25 |
| BOC | ENSG00000144857 | 0.00 | 2.80 | 0.41 | 0.36 | 2.86 | 1.61 | 0.00 | 0.00 | 0.52 | 2.19 | 0.00 | 0.81 | 0.36 | 0.00 | 0.39 | 1.67 | 2.26 | 2.79 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 1.90 | 0.00 | 0.41 | 0.00 | 2.22 | 0.00 | 0.00 |
| IGSF11 | ENSG00000144847 | 0.00 | 1.02 | 0.21 | 1.09 | 0.00 | 0.65 | 2.70 | 0.55 | 0.77 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 2.45 | 3.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.00 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC41A3 | ENSG00000114544 | 0.00 | 0.76 | 0.41 | 0.73 | 0.00 | 1.94 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| ADGRA3 | ENSG00000152990 | 1.11 | 1.78 | 0.52 | 2.55 | 0.00 | 1.61 | 5.41 | 0.00 | 0.26 | 1.00 | 0.00 | 0.27 | 0.71 | 1.47 | 0.59 | 0.00 | 3.39 | 2.36 | 1.23 | 0.00 | 1.15 | 0.00 | 1.02 | 0.78 | 0.86 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| TRPC3 | ENSG00000138741 | 1.11 | 1.27 | 0.83 | 0.73 | 0.00 | 2.26 | 2.70 | 0.55 | 0.26 | 1.59 | 0.00 | 0.00 | 0.71 | 0.74 | 0.59 | 1.11 | 2.45 | 3.86 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.86 | 3.32 | 1.36 | 0.69 | 0.41 | 0.83 | 2.22 | 0.00 | 0.00 |
| ZP3 | ENSG00000188372 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| STS | ENSG00000101846 | 1.11 | 1.27 | 0.21 | 1.09 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 1.69 | 1.50 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| HEPH | ENSG00000089472 | 2.22 | 2.29 | 0.62 | 1.09 | 2.86 | 0.65 | 2.70 | 1.66 | 0.52 | 2.59 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 1.11 | 6.78 | 6.22 | 1.23 | 1.72 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 8.29 | 2.17 | 0.69 | 0.00 | 0.00 | 3.10 | 1.82 | 0.00 |
| NLGN3 | ENSG00000196338 | 0.00 | 1.02 | 1.03 | 1.09 | 0.00 | 1.61 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.59 | 0.83 | 2.45 | 1.72 | 0.00 | 0.98 | 2.30 | 0.00 | 0.20 | 2.34 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 4.21 | 0.00 | 0.00 |
| KCNA3 | ENSG00000177272 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.97 | 2.70 | 0.55 | 0.00 | 1.59 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 1.07 | 0.00 | 1.47 | 0.00 | 0.00 | 0.61 | 0.78 | 0.43 | 0.71 | 1.63 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| SLC26A9 | ENSG00000174502 | 1.11 | 1.78 | 0.93 | 1.09 | 0.00 | 1.29 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.36 | 1.47 | 0.00 | 0.56 | 0.75 | 1.50 | 0.00 | 0.74 | 0.57 | 0.56 | 0.00 | 0.78 | 0.43 | 5.21 | 0.81 | 0.00 | 0.20 | 0.00 | 3.10 | 0.00 | 1.25 |
| SLC30A1 | ENSG00000170385 | 0.00 | 0.51 | 0.41 | 1.46 | 2.86 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 1.39 | 0.56 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 2.34 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 1.25 |
| HTR3B | ENSG00000149305 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.88 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.55 | 1.08 | 0.00 | 0.41 | 0.00 | 0.44 | 0.00 | 0.00 |
| KLRB1 | ENSG00000111796 | 2.22 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| CD69 | ENSG00000110848 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLCO1B1 | ENSG00000134538 | 0.00 | 2.04 | 0.41 | 0.73 | 0.00 | 0.97 | 0.00 | 2.21 | 0.77 | 1.20 | 0.00 | 0.54 | 0.00 | 0.74 | 1.18 | 0.56 | 2.82 | 6.87 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 2.34 | 0.86 | 3.32 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC38A4 | ENSG00000139209 | 0.00 | 0.51 | 0.41 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.00 | 0.75 | 0.64 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 6.64 | 0.81 | 0.00 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
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