Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| AQP4 | ENSG00000171885 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 0.38 | 1.50 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.86 | 0.71 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| MEP1B | ENSG00000141434 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.81 | 0.71 | 0.00 | 0.20 | 0.83 | 0.75 | 1.50 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.84 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ADGRE3 | ENSG00000131355 | 1.11 | 1.02 | 0.83 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 0.40 | 0.00 | 1.36 | 0.00 | 0.74 | 0.20 | 0.83 | 1.69 | 2.15 | 0.00 | 1.96 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 5.21 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CTLA4 | ENSG00000163599 | 2.22 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GPR1 | ENSG00000183671 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GYPA | ENSG00000170180 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| FZD1 | ENSG00000157240 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.65 | 2.70 | 1.66 | 1.03 | 1.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ADGRA2 | ENSG00000020181 | 1.11 | 1.53 | 0.10 | 1.09 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 1.20 | 1.54 | 0.81 | 1.07 | 0.74 | 0.78 | 1.39 | 0.94 | 2.36 | 0.00 | 0.00 | 1.15 | 0.56 | 0.00 | 2.34 | 0.43 | 1.42 | 1.08 | 0.69 | 0.20 | 0.00 | 1.55 | 0.00 | 1.25 |
| GRPR | ENSG00000126010 | 0.00 | 0.00 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 1.54 | 0.00 | 0.36 | 0.00 | 0.59 | 0.28 | 1.32 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GPR173 | ENSG00000184194 | 1.11 | 0.51 | 0.21 | 1.82 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.20 | 0.83 | 0.67 | 0.00 | 0.00 |
| MPL | ENSG00000117400 | 0.00 | 1.53 | 0.00 | 1.46 | 0.00 | 0.00 | 0.00 | 0.55 | 1.29 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| LRP8 | ENSG00000157193 | 0.00 | 1.27 | 0.41 | 0.36 | 2.86 | 0.00 | 2.70 | 1.66 | 0.52 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 1.11 | 0.94 | 0.86 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 1.56 | 0.86 | 0.95 | 0.54 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CLCA4 | ENSG00000016602 | 0.00 | 1.78 | 0.31 | 0.73 | 0.00 | 1.61 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.56 | 4.71 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 5.21 | 1.36 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| ABCC8 | ENSG00000006071 | 0.00 | 2.29 | 0.93 | 0.36 | 0.00 | 1.94 | 0.00 | 2.21 | 0.77 | 3.78 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 2.22 | 3.01 | 3.86 | 2.47 | 1.47 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 7.11 | 2.17 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| FOLH1 | ENSG00000086205 | 0.00 | 2.29 | 0.72 | 1.46 | 0.00 | 1.61 | 0.00 | 2.76 | 0.77 | 1.20 | 1.54 | 0.27 | 0.36 | 0.74 | 0.59 | 0.56 | 5.08 | 5.36 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 2.34 | 0.43 | 5.21 | 1.90 | 0.00 | 0.41 | 0.00 | 1.33 | 0.00 | 0.00 |
| CD163L1 | ENSG00000177675 | 2.22 | 2.54 | 1.34 | 2.19 | 0.00 | 0.97 | 5.41 | 0.55 | 2.58 | 2.99 | 0.00 | 1.08 | 0.36 | 0.00 | 0.78 | 1.67 | 5.27 | 5.15 | 1.23 | 2.70 | 0.57 | 0.00 | 0.20 | 1.56 | 0.43 | 13.51 | 2.98 | 0.00 | 0.20 | 0.83 | 2.44 | 1.82 | 0.00 |
| GUCY2C | ENSG00000070019 | 0.00 | 3.05 | 1.24 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 1.59 | 0.00 | 1.08 | 1.07 | 0.74 | 0.39 | 0.56 | 1.51 | 2.15 | 1.23 | 1.23 | 0.57 | 0.00 | 0.61 | 0.00 | 0.43 | 7.82 | 0.81 | 0.69 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| SLC16A7 | ENSG00000118596 | 2.22 | 0.51 | 0.00 | 0.73 | 0.00 | 0.65 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 3.68 | 0.00 | 0.00 | 0.94 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 3.13 | 0.00 | 1.66 | 0.27 | 0.69 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| MMP14 | ENSG00000157227 | 0.00 | 1.02 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| GP1BA | ENSG00000185245 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
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