Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| LRRN1 | ENSG00000175928 | 1.11 | 2.80 | 0.41 | 0.73 | 0.00 | 0.65 | 2.70 | 1.10 | 0.26 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 1.13 | 1.07 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 1.56 | 0.43 | 5.21 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| SLC15A2 | ENSG00000163406 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 1.00 | 0.00 | 1.36 | 0.36 | 0.74 | 0.20 | 0.56 | 1.13 | 2.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.13 | 0.00 | 8.53 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| FGFRL1 | ENSG00000127418 | 0.00 | 0.51 | 0.21 | 0.36 | 2.86 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.56 | 0.56 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC2A9 | ENSG00000109667 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.28 | 1.32 | 1.07 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 2.37 | 0.54 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| GABRA2 | ENSG00000151834 | 2.22 | 1.02 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 3.87 | 0.26 | 2.19 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 1.11 | 4.33 | 5.79 | 0.00 | 1.23 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 5.45 | 1.90 | 0.00 | 0.41 | 0.00 | 1.11 | 0.00 | 0.00 |
| AREG | ENSG00000109321 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| ADAM19 | ENSG00000135074 | 0.00 | 1.27 | 0.93 | 1.09 | 0.00 | 0.65 | 0.00 | 1.66 | 0.26 | 1.59 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 0.56 | 3.58 | 2.15 | 0.00 | 1.47 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.79 | 1.36 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| NCR3 | ENSG00000204475 | 0.00 | 0.00 | 0.00 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 1.25 |
| PI16 | ENSG00000164530 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.29 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 2.61 | 0.81 | 0.00 | 0.00 | 0.83 | 0.22 | 0.00 | 0.00 |
| SLC22A16 | ENSG00000004809 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 1.59 | 0.00 | 0.54 | 0.71 | 0.74 | 0.00 | 0.56 | 2.45 | 1.93 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.84 | 1.36 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC12A9 | ENSG00000146828 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.97 | 2.70 | 0.55 | 0.26 | 1.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 1.32 | 2.79 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 1.56 | 0.43 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| SLC26A5 | ENSG00000170615 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 1.03 | 1.20 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.00 | 1.32 | 2.36 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 1.25 |
| AQP3 | ENSG00000165272 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC44A1 | ENSG00000070214 | 1.11 | 0.25 | 0.31 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.56 | 1.69 | 0.43 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 1.18 | 0.27 | 0.00 | 0.20 | 0.83 | 0.89 | 1.82 | 0.00 |
| NEGR1 | ENSG00000172260 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 2.70 | 2.21 | 0.77 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.28 | 1.69 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.18 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| BST1 | ENSG00000109743 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| HHIP | ENSG00000164161 | 1.11 | 1.02 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.39 | 0.75 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.81 | 0.00 | 0.43 | 4.27 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 3.64 | 0.00 |
| OPCML | ENSG00000183715 | 0.00 | 2.29 | 0.21 | 1.09 | 0.00 | 1.94 | 2.70 | 2.21 | 0.26 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.11 | 2.07 | 3.00 | 1.23 | 0.98 | 0.57 | 0.00 | 0.41 | 3.91 | 0.43 | 1.42 | 2.71 | 0.00 | 0.20 | 0.83 | 1.33 | 0.00 | 0.00 |
| TFPI | ENSG00000003436 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| NID2 | ENSG00000087303 | 2.22 | 3.05 | 0.31 | 1.09 | 0.00 | 1.94 | 2.70 | 1.66 | 0.26 | 2.59 | 0.00 | 0.54 | 1.42 | 0.00 | 0.00 | 2.50 | 4.71 | 5.15 | 0.00 | 0.98 | 0.00 | 0.56 | 0.81 | 2.34 | 0.00 | 5.92 | 1.08 | 0.00 | 0.20 | 0.00 | 5.10 | 1.82 | 0.00 |
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