Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| NPC1L1 | ENSG00000015520 | 1.11 | 2.54 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.54 | 0.36 | 0.74 | 0.39 | 1.11 | 3.20 | 3.43 | 0.00 | 1.47 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 5.45 | 1.08 | 0.69 | 0.41 | 0.00 | 2.88 | 1.82 | 0.00 |
| ABCB4 | ENSG00000005471 | 0.00 | 2.04 | 0.83 | 2.55 | 0.00 | 1.29 | 0.00 | 1.10 | 1.80 | 2.39 | 0.00 | 0.54 | 0.71 | 0.00 | 0.59 | 1.11 | 2.45 | 3.22 | 1.23 | 2.70 | 0.00 | 0.00 | 0.20 | 1.56 | 1.29 | 2.84 | 2.71 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| ACHE | ENSG00000087085 | 0.00 | 1.53 | 0.00 | 0.73 | 2.86 | 0.00 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 0.56 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.86 | 1.42 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| MUC17 | ENSG00000169876 | 2.22 | 11.20 | 3.41 | 9.12 | 0.00 | 5.16 | 2.70 | 8.29 | 6.70 | 6.77 | 1.54 | 3.52 | 2.49 | 0.74 | 2.94 | 3.89 | 17.14 | 15.88 | 1.23 | 5.64 | 2.87 | 1.12 | 2.85 | 4.69 | 4.31 | 22.75 | 8.13 | 0.00 | 0.81 | 0.00 | 7.32 | 7.27 | 1.25 |
| TRPV5 | ENSG00000127412 | 0.00 | 2.04 | 0.21 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 1.80 | 1.79 | 0.00 | 0.54 | 0.36 | 0.00 | 0.59 | 1.11 | 3.77 | 3.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 8.53 | 1.08 | 0.69 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| SCARA5 | ENSG00000168079 | 0.00 | 0.25 | 0.21 | 0.00 | 2.86 | 0.65 | 0.00 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.56 | 1.51 | 1.50 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ADAM9 | ENSG00000168615 | 0.00 | 1.02 | 0.31 | 2.19 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 2.15 | 1.23 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.18 | 0.00 | 0.69 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| CRB2 | ENSG00000148204 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.00 | 0.71 | 0.74 | 0.39 | 0.28 | 2.07 | 1.07 | 0.00 | 0.25 | 1.72 | 0.00 | 0.41 | 0.00 | 0.43 | 3.55 | 1.08 | 0.69 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| GJB1 | ENSG00000169562 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.56 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GRIA3 | ENSG00000125675 | 0.00 | 0.76 | 1.65 | 1.82 | 0.00 | 0.97 | 0.00 | 2.21 | 1.03 | 1.39 | 0.00 | 0.54 | 0.00 | 2.94 | 0.98 | 1.67 | 3.20 | 4.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 3.13 | 0.00 | 4.74 | 0.81 | 0.00 | 0.00 | 0.00 | 3.10 | 5.45 | 0.00 |
| CD40LG | ENSG00000102245 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ATP2B3 | ENSG00000067842 | 3.33 | 0.76 | 1.34 | 1.82 | 0.00 | 2.58 | 0.00 | 1.10 | 1.29 | 1.99 | 0.00 | 0.00 | 0.71 | 0.74 | 0.39 | 1.11 | 3.01 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 1.66 | 1.90 | 0.00 | 0.20 | 0.00 | 5.54 | 0.00 | 0.00 |
| CD55 | ENSG00000196352 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GRID1 | ENSG00000182771 | 1.11 | 2.54 | 1.24 | 0.36 | 0.00 | 2.26 | 5.41 | 1.10 | 0.26 | 3.59 | 0.00 | 0.81 | 0.36 | 0.74 | 0.20 | 1.11 | 4.71 | 5.36 | 0.00 | 1.23 | 1.15 | 0.00 | 0.81 | 0.78 | 0.43 | 4.74 | 4.34 | 0.00 | 0.00 | 0.00 | 3.77 | 1.82 | 1.25 |
| FOLR2 | ENSG00000165457 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.69 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| VASN | ENSG00000168140 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.00 | 0.43 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SPN | ENSG00000197471 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.19 | 0.64 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CD37 | ENSG00000104894 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 1.07 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SCN2A | ENSG00000136531 | 2.22 | 2.80 | 1.76 | 0.73 | 0.00 | 3.55 | 2.70 | 3.87 | 0.77 | 2.19 | 1.54 | 0.54 | 1.07 | 2.21 | 0.78 | 1.94 | 5.27 | 11.16 | 1.23 | 1.47 | 0.57 | 0.56 | 0.81 | 1.56 | 5.60 | 12.56 | 4.88 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 1.25 |
| ABCB11 | ENSG00000073734 | 1.11 | 0.51 | 1.03 | 0.73 | 0.00 | 1.29 | 0.00 | 2.21 | 0.77 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 1.11 | 4.33 | 3.00 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 1.56 | 1.29 | 6.87 | 0.81 | 0.00 | 0.81 | 0.00 | 1.77 | 0.00 | 0.00 |
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