Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CD226 | ENSG00000150637 | 0.00 | 0.76 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 2.07 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 0.00 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| HPN | ENSG00000105707 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.94 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.95 | 0.27 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| AXL | ENSG00000167601 | 1.11 | 1.02 | 0.52 | 0.73 | 0.00 | 0.97 | 2.70 | 0.55 | 0.52 | 1.00 | 0.00 | 0.81 | 0.00 | 0.74 | 0.39 | 0.00 | 0.94 | 0.64 | 1.23 | 0.74 | 0.57 | 0.00 | 0.61 | 0.00 | 0.86 | 2.61 | 1.08 | 0.00 | 0.00 | 0.83 | 3.55 | 1.82 | 0.00 |
| ATP1A3 | ENSG00000105409 | 1.11 | 1.53 | 0.52 | 1.82 | 2.86 | 0.32 | 2.70 | 0.55 | 0.77 | 1.59 | 0.00 | 0.81 | 1.07 | 0.74 | 0.20 | 1.11 | 1.69 | 3.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 0.00 | 1.29 | 6.64 | 2.17 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| GRIK5 | ENSG00000105737 | 1.11 | 2.54 | 0.41 | 1.09 | 0.00 | 1.94 | 0.00 | 1.10 | 0.52 | 1.39 | 0.00 | 0.81 | 0.36 | 0.74 | 0.20 | 0.28 | 2.07 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 1.90 | 2.44 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SIGLEC9 | ENSG00000129450 | 0.00 | 0.51 | 0.62 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 1.03 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 2.82 | 1.72 | 0.00 | 0.00 | 0.00 | 0.56 | 0.41 | 0.78 | 0.86 | 1.42 | 1.08 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CHRNA1 | ENSG00000138435 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 1.66 | 0.26 | 0.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.39 | 0.83 | 1.88 | 2.15 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| SLC40A1 | ENSG00000138449 | 0.00 | 0.51 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.28 | 1.32 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.00 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 1.25 |
| CHRND | ENSG00000135902 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 1.03 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 2.45 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PDCD1 | ENSG00000188389 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| GGT7 | ENSG00000131067 | 0.00 | 0.51 | 0.21 | 1.09 | 0.00 | 0.32 | 0.00 | 1.66 | 0.77 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 0.19 | 0.64 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| IL10RB | ENSG00000243646 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| BTLA | ENSG00000186265 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.83 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SLCO2A1 | ENSG00000174640 | 0.00 | 1.02 | 0.72 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.59 | 0.56 | 1.69 | 3.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.08 | 1.36 | 0.00 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| SI | ENSG00000090402 | 3.33 | 3.82 | 1.65 | 3.65 | 0.00 | 1.61 | 5.41 | 7.18 | 1.55 | 9.36 | 0.00 | 0.81 | 1.07 | 0.74 | 1.37 | 3.06 | 13.37 | 16.31 | 0.00 | 5.39 | 1.15 | 0.00 | 1.02 | 0.78 | 0.00 | 18.01 | 5.15 | 0.69 | 0.00 | 0.00 | 7.32 | 3.64 | 0.00 |
| SLC34A1 | ENSG00000131183 | 1.11 | 1.02 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.81 | 1.07 | 0.74 | 0.39 | 0.83 | 2.45 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HLA-DRB5 | ENSG00000198502 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| HLA-DPA1 | ENSG00000231389 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 2.70 | 0.55 | 0.26 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| HLA-DPB1 | ENSG00000223865 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.41 | 0.83 | 0.00 | 0.00 | 0.00 |
| GPNMB | ENSG00000136235 | 1.11 | 2.04 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 1.36 | 1.07 | 0.00 | 0.20 | 0.00 | 1.51 | 1.29 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 0.47 | 0.27 | 0.69 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
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