Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| LAMP2 | ENSG00000005893 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 0.75 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| FNDC5 | ENSG00000160097 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| TIE1 | ENSG00000066056 | 1.11 | 2.80 | 0.00 | 2.19 | 0.00 | 0.65 | 0.00 | 0.55 | 1.03 | 1.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.28 | 1.88 | 2.79 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 1.56 | 1.29 | 4.98 | 2.71 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| ROR1 | ENSG00000185483 | 1.11 | 1.02 | 0.93 | 0.36 | 2.86 | 1.29 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 1.51 | 1.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 3.32 | 1.90 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| ITGA10 | ENSG00000143127 | 0.00 | 1.53 | 0.62 | 1.46 | 0.00 | 1.29 | 5.41 | 1.66 | 1.29 | 1.39 | 0.00 | 0.54 | 1.07 | 1.47 | 0.39 | 1.39 | 1.88 | 3.00 | 0.00 | 1.72 | 0.00 | 0.56 | 0.41 | 2.34 | 1.29 | 3.08 | 0.81 | 0.00 | 0.41 | 0.00 | 1.55 | 1.82 | 0.00 |
| FCGR1A | ENSG00000150337 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.75 | 0.00 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| FCRL5 | ENSG00000143297 | 1.11 | 1.02 | 0.93 | 1.82 | 0.00 | 1.61 | 0.00 | 2.76 | 1.29 | 1.39 | 0.00 | 0.81 | 0.00 | 0.00 | 0.78 | 1.94 | 3.01 | 5.36 | 1.23 | 1.47 | 0.00 | 0.00 | 0.41 | 2.34 | 0.86 | 11.61 | 1.36 | 0.00 | 0.20 | 0.00 | 0.89 | 1.82 | 0.00 |
| FCRL3 | ENSG00000160856 | 1.11 | 1.53 | 0.41 | 0.73 | 0.00 | 1.29 | 0.00 | 2.76 | 0.26 | 1.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 2.45 | 5.15 | 1.23 | 0.49 | 0.00 | 0.56 | 0.41 | 2.34 | 0.00 | 3.55 | 3.25 | 0.00 | 0.00 | 0.00 | 3.55 | 1.82 | 0.00 |
| FCRL2 | ENSG00000132704 | 1.11 | 0.76 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 1.03 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 3.77 | 4.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.42 | 0.81 | 0.00 | 0.41 | 0.00 | 1.11 | 1.82 | 0.00 |
| CD84 | ENSG00000066294 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.32 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.61 | 0.27 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLAMF1 | ENSG00000117090 | 0.00 | 0.00 | 0.31 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.32 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.81 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| FCGR3B | ENSG00000162747 | 0.00 | 1.53 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 1.51 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ZP4 | ENSG00000116996 | 1.11 | 1.78 | 1.14 | 0.36 | 0.00 | 0.32 | 5.41 | 0.00 | 1.29 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.83 | 7.53 | 3.65 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.84 | 2.71 | 0.00 | 0.00 | 0.83 | 1.55 | 0.00 | 0.00 |
| C10orf54 | ENSG00000107738 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.86 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KCNK18 | ENSG00000186795 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.65 | 2.70 | 0.00 | 0.77 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 2.64 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 1.36 | 0.00 | 0.41 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC22A6 | ENSG00000197901 | 0.00 | 0.25 | 0.72 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 1.36 | 0.00 | 0.74 | 0.39 | 0.00 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.37 | 1.08 | 0.00 | 0.20 | 0.83 | 0.67 | 0.00 | 0.00 |
| FLRT1 | ENSG00000126500 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.65 | 2.70 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.00 | 0.19 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| SLC22A11 | ENSG00000168065 | 0.00 | 0.51 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 1.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 1.13 | 0.43 | 1.23 | 0.25 | 1.15 | 0.56 | 0.20 | 0.78 | 0.43 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CA12 | ENSG00000074410 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.28 | 0.19 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SCNN1G | ENSG00000166828 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 1.29 | 5.41 | 1.66 | 1.55 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 1.11 | 0.56 | 1.72 | 1.23 | 0.74 | 0.57 | 0.00 | 0.00 | 1.56 | 1.29 | 4.03 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
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