Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| FCER1A | ENSG00000179639 | 0.00 | 1.27 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 1.32 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 3.55 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PIGR | ENSG00000162896 | 0.00 | 1.27 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.77 | 0.80 | 0.00 | 0.81 | 1.07 | 0.00 | 0.00 | 0.28 | 0.75 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 3.79 | 2.71 | 0.69 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| CR1 | ENSG00000203710 | 0.00 | 3.05 | 1.14 | 2.19 | 0.00 | 4.19 | 0.00 | 0.55 | 0.00 | 2.19 | 0.00 | 1.63 | 0.71 | 0.00 | 0.78 | 2.78 | 4.71 | 6.22 | 2.47 | 0.98 | 0.57 | 0.00 | 0.20 | 1.56 | 0.43 | 10.66 | 3.25 | 0.69 | 0.20 | 0.00 | 2.88 | 0.00 | 0.00 |
| PCDH15 | ENSG00000150275 | 7.78 | 6.62 | 1.86 | 3.28 | 0.00 | 7.42 | 10.81 | 8.29 | 1.03 | 8.57 | 1.54 | 2.98 | 1.78 | 0.74 | 0.59 | 5.56 | 16.38 | 18.88 | 0.00 | 3.43 | 4.60 | 0.00 | 1.83 | 3.13 | 0.86 | 21.09 | 13.28 | 1.39 | 0.41 | 0.00 | 7.10 | 1.82 | 0.00 |
| KLRK1 | ENSG00000213809 | 1.11 | 0.00 | 0.21 | 0.00 | 0.00 | 0.65 | 2.70 | 1.10 | 0.26 | 0.00 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 1.11 | 0.75 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PTPRR | ENSG00000153233 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 2.70 | 0.55 | 1.03 | 1.00 | 0.00 | 0.54 | 1.42 | 0.00 | 0.20 | 0.56 | 1.69 | 3.22 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.74 | 0.81 | 0.00 | 0.41 | 0.00 | 1.77 | 0.00 | 0.00 |
| GPR65 | ENSG00000140030 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.88 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GPR132 | ENSG00000183484 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 1.29 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.56 | 0.56 | 0.64 | 0.00 | 0.49 | 0.57 | 0.56 | 0.20 | 0.00 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC14A1 | ENSG00000141469 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| MAG | ENSG00000105695 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 1.29 | 0.00 | 1.66 | 1.03 | 0.60 | 1.54 | 0.00 | 0.71 | 0.00 | 0.59 | 0.83 | 1.32 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 2.34 | 0.86 | 1.42 | 1.08 | 1.39 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| IL1RL1 | ENSG00000115602 | 1.11 | 0.51 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.98 | 0.00 | 2.26 | 2.36 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.86 | 5.69 | 0.81 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GYPC | ENSG00000136732 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 0.24 | 1.08 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SUCNR1 | ENSG00000198829 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CORIN | ENSG00000145244 | 1.11 | 1.78 | 0.41 | 0.36 | 0.00 | 0.97 | 2.70 | 0.00 | 0.77 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 2.45 | 3.65 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 2.34 | 0.43 | 5.92 | 1.63 | 0.00 | 0.20 | 0.00 | 1.55 | 1.82 | 0.00 |
| SLC1A3 | ENSG00000079215 | 1.11 | 0.25 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.20 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 2.82 | 1.07 | 0.00 | 0.49 | 1.15 | 0.56 | 0.00 | 2.34 | 0.00 | 2.37 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| BTN3A1 | ENSG00000026950 | 1.11 | 1.02 | 0.41 | 0.00 | 2.86 | 0.00 | 0.00 | 2.21 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.32 | 0.86 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| AGER | ENSG00000204305 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ADGRF1 | ENSG00000153292 | 0.00 | 1.78 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.39 | 0.00 | 0.81 | 0.36 | 0.00 | 0.59 | 1.39 | 0.19 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 3.32 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SIT1 | ENSG00000137078 | 0.00 | 0.25 | 0.10 | 0.00 | 2.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ACE2 | ENSG00000130234 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.00 | 2.70 | 1.10 | 0.77 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.32 | 1.50 | 0.00 | 0.25 | 1.15 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
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