Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PTGDR2 | ENSG00000183134 | 1.11 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.27 | 0.69 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ATP2B1 | ENSG00000070961 | 0.00 | 1.78 | 1.03 | 0.73 | 2.86 | 0.65 | 0.00 | 2.21 | 0.00 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 2.36 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 1.29 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| SLC4A1 | ENSG00000004939 | 0.00 | 0.51 | 0.41 | 1.09 | 0.00 | 1.61 | 0.00 | 0.55 | 1.55 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.56 | 2.45 | 2.15 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.86 | 4.27 | 0.81 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 1.25 |
| S1PR2 | ENSG00000267534 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GIPR | ENSG00000010310 | 1.11 | 0.76 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| FSHR | ENSG00000170820 | 1.11 | 1.02 | 0.83 | 1.09 | 0.00 | 2.26 | 0.00 | 1.66 | 0.26 | 1.99 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.11 | 3.95 | 7.30 | 0.00 | 1.23 | 0.57 | 0.00 | 0.41 | 2.34 | 0.00 | 5.69 | 3.52 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| GABBR2 | ENSG00000136928 | 0.00 | 1.53 | 0.72 | 0.00 | 0.00 | 0.65 | 2.70 | 1.66 | 0.52 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 1.51 | 1.29 | 0.00 | 1.23 | 0.57 | 0.00 | 0.61 | 3.13 | 0.00 | 1.90 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| GPR37L1 | ENSG00000170075 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.78 | 0.43 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OR2C3 | ENSG00000196242 | 1.11 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 1.00 | 1.54 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 3.58 | 3.22 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| TACR2 | ENSG00000075073 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.56 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| AQP5 | ENSG00000161798 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| LGR5 | ENSG00000139292 | 0.00 | 2.04 | 0.72 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.83 | 4.33 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 3.55 | 0.81 | 0.00 | 0.20 | 0.00 | 0.89 | 3.64 | 0.00 |
| HCAR2 | ENSG00000182782 | 0.00 | 1.78 | 0.31 | 0.73 | 0.00 | 0.00 | 2.70 | 2.76 | 0.52 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.90 | 0.27 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| LTB4R2 | ENSG00000213906 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PTGER2 | ENSG00000125384 | 0.00 | 1.27 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.28 | 0.19 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 1.25 |
| GABRA5 | ENSG00000186297 | 0.00 | 1.02 | 0.52 | 0.73 | 0.00 | 2.90 | 0.00 | 0.55 | 1.55 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 3.39 | 2.36 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 2.34 | 1.29 | 1.18 | 1.36 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SSTR5 | ENSG00000162009 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 1.07 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| GLP2R | ENSG00000065325 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 1.10 | 0.26 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 3.01 | 3.22 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 2.37 | 1.63 | 0.00 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
| GPR142 | ENSG00000257008 | 1.11 | 1.53 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 2.26 | 1.93 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 1.90 | 0.54 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| S1PR4 | ENSG00000125910 | 1.11 | 1.02 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 1.08 | 0.00 | 0.74 | 0.20 | 0.28 | 0.38 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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